Prevalence and significance of T-wave inversions in predominantly Caucasian adolescent athletes

European Heart Journal

Volumn 30, Issue 14, 2009, Pages 1728-1735

  Papadakis, Michael ^a,b   Basavarajaiah, Sandeep ^a,b   Rawlins, John ^a,b   Edwards, Carey ^a,b   Makan, Jayesh ^c   Firoozi, Sami ^d   Carby, Lorna ^b   Sharma, Sanjay ^a,b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL LEWISHAM   (United Kingdom)

^c HAREFIELD HOSPITAL   (United Kingdom)

^d ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Adolescent; Athelete's heart; Electrocardiography; Pre participation; T wave inversion

Indexed keywords

ADOLESCENT; ARTICLE; ATHLETE; CARDIOMYOPATHY; CAUCASIAN; CONGENITAL HEART DISEASE; CONTROLLED STUDY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; EXERCISE TOLERANCE; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE DYSPLASIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; T WAVE INVERSION;

ADOLESCENT; CARDIOMYOPATHIES; CASE-CONTROL STUDIES; DEATH, SUDDEN, CARDIAC; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GREAT BRITAIN; HUMANS; MALE; SPORTS;

EID: 67651102924     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp164     Document Type: Article

References (42)

1. Makan J, Sharma S, Firoozi S, Whyte G, Jackson PG, McKenna WJ. Physiological upper limits of ventricular cavity size in highly trained adolescent athletes. Heart 2005;91:495-499.
2. Pelliccia A, Culasso F, Di Paolo FM, Maron BJ. Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med 1999;130:23-31.
3. Smith ML, Hudson DL, Graitzer HM, Raven PB. Exercise training bradycardia: the role of autonomic balance. Med Sci Sports Exerc 1989;21:40-44.
4. Sharma S, Whyte G, Elliott P, Padula M, Kaushal R, Mahon N, McKenna WJ. Electrocardiographic changes in 1000 highly trained junior elite athletes. Br J Sports Med 1999;33:319-324.
5. Pelliccia A, Maron BJ, Culasson F, Di Paolo FM, Spartaro A, Biffi A, Caselli G, Piovano P. Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation 2000;102:278-284.
6. Ryan MP, Cleland JGF, French JA, Joshi J, Choudhury L, Choinowska L, Michalak E, Al-Mahdawi S, Nihoyannopoulos P, Oakley CM. The standard electrocardiogram as a screening test for hypertrophic cardiomyopathy. Am J Cardiol 1995;76: 689-694.
7. Marcus FI. Prevalence of T-wave inversion beyond V1 in young normal individuals and usefulness for the diagnosis of arrhythmogenic right ventricular cardiomyopathy/ dysplasia. Am J Cardiol 2005;95:1070-1071.
8. Maron BJ. Sudden death in young athletes. N Eng J Med 2003;349:1064-1075.
9. Corrado D, Basso C, Schiavon M, Thiene G. Screening for hypertrophic cardiomyopathy in young athletes. N Engl J Med 1998;339:364-369.
10. Pelliccia A, Culasso F, Di Paolo FM, Accettura D, Cantore R, Castagna W, Ciacciarelli A, Costini G, Cuffari B, Drago E, Federici V, Gribaudo CG, Lacovelli G, Landolfi L, Menichetti G, Atzeni UO, Parisi A, Pizzi AR, Rosa M, Santelli F, Santilio F, Vagnini A, Casasco M, Di Luigi L. Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening. Eur Heart J 2007;28:2006-2010.
11. Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO. Sudden death in young competitive athletes: clinical, demographic, and pathological profiles. J Am Med Assoc 1996;276:199-204.
12. Ostman-Smith I, Wettrell G, Keeton B, Holmgren D, Ergander U, Gould S, Bowker C, Verdicchio M. Age- and gender-specific mortality rates in childhood hypertrophic cardiomyopathy. Eur Heart J 2008;29:1160-1167.
13. Friedmann HH. Diagnostic Electrocardiography and Vecterocardiography. New York: McGraw-Hill; 1971.
14. Bazzet HC. An analysis of the time relations of electrocardiograms. Heart 1920;7: 353-367.
15. Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy obtained by unipolar precordial and limb leads. Am Heart J 1949;37:161-186.
16. Tajik AJ, Seward JB, Hagler DJ, Mair DD, Lie JT. Two dimensional real time ultrasound imaging of the heart and great vessels: technique, image orientation, structure identification and validation. Mayo Clin Proc 1978;53:271-303.
17. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Steward WJ. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440-1463.
18. Chan KL, Currie PJ, Seward JB, Hagler DJ, Mair DD, Tajik AJ. Comparison of 3 Doppler ultrasound methods in the prediction of pulmonary artery pressure. J Am Coll Cardiol 1987;9:549-554.
19. Sharma S, Maron BJ, Whyte G, Firoozi S, Elliott PM, McKenna WJ. Physiologic limits of left ventricular hypertrophy in elite junior athletes: relevance to differential diagnosis of athlete's heart and hypertrophic cardiomyopathy. J Am Coll Cardiol 2002;40:1431-1436.
20. Lewis JF, Spirito P, Pellicia A, Maron BJ. Usefulness of Doppler echocardiographic assessment of diastolic filling in distinguishing 'athlete's heart' from hypertrophic cardiomyopathy. Br Heart J 1992;68:296- 300.
21. Basavarajaiah S, Makan J, Naghavi SH, Whyte G, Gati S, Sharma S. Physiologic upper limits of left atrial diameter in highly trained adolescent athletes. J Am Coll Cardiol 2006;47:2341-2342.
22. Sen-Chowdhry S, Lowe MD, Sporton SC, McKenna WJ. Arrhythmogenic right ventricular cardiomyopathy: clinical presentation, diagnosis, and management. Am J Med 2004;117:685-695.
23. Kim YJ, Choi BW, Hur J, Lee HJ, Seo JS, Kim TH, Choe KO, Ha JW. Delayed enhancement in hypertrophic cardiomyopathy: comparison with myocardial tagging MRI. J Magn Reson Imaging 2008;27:1054-1060.
24. Tandri H, Saranathan M, Rodriguez ER, Martinez C, Bomma C, Nasir K, Rosen B, Lima JA, Calkins H, Bluemke DA. Noninvasive detection of myocardial fibrosis in Arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement magnetic resonance imaging. J Am Coll Cardiol 2005;45:98-103.
25. Bruce RA. Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Ann Clin Res 1971;3:323-332.
26. Frenneaux MP, Counihan PJ, Caforio AL, Chikamori T, McKenna WJ. Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy. Circulation 1990;82:1995-2002.
27. Monseratt L, Elliott PM, Gimeno JR, Sharma S, Penas-Lado M, McKenna WJ. Nonsustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent risk marker of sudden death in young patients. J Am Coll Cardiol 2003;42: 873-879.
28. Biffi A, Pelliccia A, Verdile L, Fernando F, Spataro A, Caselli S, Santini M, Maron BJ. Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol 2002;40:446-452.
29. Grothues F, Smith GC, Moon JC, Bellenger NG, Collins P, Klein HU, Pennell DJ. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol 2002;90:29-34.
30. Grothues F, Moon JC, Bellenger NG, Smith GS, Klein HU, Pennell DJ. Interstudy reproducibility of right ventricular volumes, function and mass with cardiovascular magnetic resonance. Am Heart J 2004;147:218-223.
31. McKenna WJ, Thiene G, Nava A, Fontaliran F, Blomstrom-Lundqvist C, Fontaine G, Camerini F. Diagnosis of arrhythmogenic right ventricular dysplasia/ cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology. Br Heart J 1994;71:215-218.
32. Maron BJ. Hypertrophic cardiomyopathy: a systematic review. J Am Med Assoc 2002;287:1308-1320.
33. Savage DD, Seides SF, Clark CE, Henry WL, Maron BJ, Robinson FC, Epstein SE. Electrocardiographic findings in patients with obstructive and non-obstructive hypertrophic cardiomyopathy. Circulation 1978;58:402-408.
34. Thiene G, Nava A, Corrado D, Rossi L, Pennelli N. Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med 1988;318:129-133.
35. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden death in young competitive athletes after implementation of a preparticipation screening program. J Am Med Assoc 2006;296:1593- 1601.
36. Pelliccia A, Di Paolo FM, Corrado D, Buccolieri C, Quattrini FM, Pisicchio C, Spataro A, Biffi A, Granata M, Maron BJ. Evidence for efficacy of the Italian national pre-participation screening programme for identification of hypertrophic cardiomyopathy in competitive athletes. Eur Heart J 2006;27:2196-2000.
37. Pellicia A, Maron BJ. Preparticipation cardiovascular evaluation of the competitive athlete: perspectives from the 30-year Italian experience. Am J Cardiol 1995;75: 827-829.
38. Corrado D, Pelliccia A, Bjørnstad HH, Vanhees L, Biffi A, Borjesson M et al. Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J 2005;26:516-520.
39. Bille K, Fiquiras D, Schamasch P. Sudden cardiac death in athletes. The Lausanne recommendations. Eur J Cardiovasc Prev Rehabil 2006;13:859-875.
40. Lipshultz SE, Sleeper LA, Towbin JA, Lowe AM, Orav EJ, Cox GF, Lurie PR, McRoy KL, McDonald MA, Messere JE, Colan SD. The incidence of paediatric cardiomyopathy in two regions of the United States. N Engl J Med 2003;348: 1647-1655.
41. Nugent AW, Daubebey PEF, Chondros P, Carlin JB, Cheung M, Wilkinson LC, Davis AM, Kahler SG, Chow CW, Wilkinson JL,Weintraub RG. The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med 2003;348:1639- 1646.
42. Pelliccia A, Di Paolo FM, Quattrini FM, Basso C, Culasso F, Popoli G, De Luca R, Spataro A, Biffi A, Thiene G, Maron BJ. Outcomes in athletes with marked ECG repolarization abnormalities. N Engl J Med 2008;358:152-161.