Cultivated anti-Aspergillus TH1 cells

Medical Mycology

Volumn 47, Issue SUPPL. 1, 2009, Pages

  Lehrnbecher, Thomas ^a   Beck, Olaf ^a   Koehl, Ulrike ^a   Tramsen, Lars ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Adoptive immunotherapy; Invasive aspergillosis; TH1 cells

Indexed keywords

ANTIVIRUS AGENT; CORTICOSTEROID; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

ADAPTIVE IMMUNITY; ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ALLOGENEIC STEM CELL TRANSPLANTATION; ALTERNARIA ALTERNATA; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; CANDIDA ALBICANS; CD4+ T LYMPHOCYTE; CELL THERAPY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; FUNGUS CULTURE; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOCOMPROMISED PATIENT; LYMPHOCYTE PROLIFERATION; NEUTROPENIA; NONHUMAN; PENICILLIUM CHRYSOGENUM; RISK FACTOR; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; ASPERGILLUS; CELL CULTURE; IMMUNE DEFICIENCY; IMMUNOLOGY; REVIEW;

ALTERNARIA ALTERNATA; ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; CANDIDA ALBICANS; FUNGI; PENICILLIUM CHRYSOGENUM;

ADOPTIVE TRANSFER; ASPERGILLOSIS; ASPERGILLUS; CELLS, CULTURED; HUMANS; IMMUNOCOMPROMISED HOST; PENICILLIUM CHRYSOGENUM; TH1 CELLS;

EID: 67651099226     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780802169120     Document Type: Article

References (36)

1. Hebart H, Einsele H. Specific infectious complications after stem cell transplantation. Support Care Cancer 2004; 12: 80-85.
2. Lin SJ, Schranz J, Teutsch SM. Aspergillosis case-fatality rate: systematic review of the literature. Clin Infect Dis 2001; 32 358-366.
3. Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002; 34: 909-917.
4. Husain S, Alexander BD, Munoz P, et al. Opportunistic mycelial fungal infections in organ transplant recipients: Emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis 2003; 37 221-229.
5. Gerson SL, Talbot GH, Hurwitz S, et al. Prolonged granulocytopenia: The major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med 1984; 100: 345-351.
6. Denning DW. Invasive aspergillosis. Clin Infect Dis 1998; 26 781-803; quiz 804-805.
7. Wald A, Leisenring W, van Burik JA, Bowden RA. Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. J Infect Dis 1997; 175: 1459-1466.
8. Hamza NS, Lisgaris M, Yadavalli G, et al. Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol 2004; 124: 488-498.
9. Fukuda T, Boeckh M, Carter RA, et al. Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning. Blood 2003; 102: 827-833.
10. Marr KA, Carter RA, Boeckh M, Martin P, Corey L. Invasive aspergillosis in allogeneic stem cell transplant recipients: Changes in epidemiology and risk factors. Blood 2002; 100: 4358-4366.
11. Kurup VP, Hari V, Guo J, et al. Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines. Peptides 1996; 17: 183-190.
12. Bozza S, Gaziano R, Spreca A, et al. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 2002; 168: 1362-1371.
13. Gafa V, Remoli ME, Giacomini E, et al. In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment. Microbes Infect 2007; 9: 971-980.
14. Bozza S, Perruccio K, Montagnoli C, et al. A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 2003; 102: 3807-3814.
15. Cenci E, Mencacci A, Bacci A, et al. T cell vaccination in mice with invasive pulmonary aspergillosis. J Immunol 2000; 165: 381-388.
16. Hebart H, Bollinger C, Fisch P, et al. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood 2002; 100: 4521-4528.
17. Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 2002; 99: 3916-3922.
18. Savoldo B, Cubbage ML, Durett AG, et al. Generation of EBVspecific CD4+ cytotoxic T cells from virus naive individuals. J Immunol 2002; 168: 909-918.
19. Pakakasama S, Eames GM, Morriss MC, et al. Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes. Transplantation 2004; 78: 755-757.
20. Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 2006; 134: 64-76.
21. Einsele H, Hebart H. Cellular immunity to viral and fungal antigens after stem cell transplantation. Curr Opin Hematol 2002; 9: 485-489.
22. Ramadan G, Davies B, Kurup VP, Keever-Taylor CA. Generation of cytotoxic T cell responses directed to human leucocyte antigen Class I restricted epitopes from the Aspergillus f16 allergen. Clin Exp Immunol 2005; 140: 81-91.
23. Perruccio K, Tosti A, Burchielli E, et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005; 106: 4397-4406.
24. Rauser G, Einsele H, Sinzger C, et al. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood 2004; 103: 3565-3572.
25. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12: 310-350.
26. Beck O, Topp MS, Koehl U, et al. Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus. Blood 2006; 107: 2562-2569.
27. Beck O, Koehl U, Tramsen L, et al. Enumeration of functionally active anti-Aspergillus T-cells in human peripheral blood. J Immunol Methods 2008; 335: 41-45.
28. Tamir A, Basagila E, Kagahzian A, et al. Induction of tumorspecific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic- antigen positive tumors. Cancer Immunol Immunother 2007; 56: 2003-2016.
29. Yamanaka R, Honma J, Tsuchiya N, et al. Tumor lysate and IL-18 loaded dendritic cells elicits Th1 response, tumor-specific CD8+ cytotoxic T cells in patients with malignant glioma. J Neurooncol 2005; 72: 107-113.
30. Bollard CM, Kuehnle I, Leen A, Rooney CM, Heslop HE. Adoptive immunotherapy for posttransplantation viral infections. Biol Blood Marrow Transplant 2004; 10: 143-155.
31. Roilides E, Holmes A, Blake C, et al. Antifungal activity of elutriated human monocytes against Aspergillus fumigatus hyphae: enhancement by granulocyte-macrophage colony-stimulating factor and interferon-gamma. J Infect Dis 1994; 170: 894-899.
32. Akpogheneta O, Gil-Lamaignere C, Maloukou A, Roilides E. Antifungal activity of human polymorphonuclear and mononuclear phagocytes against non-fumigatus Aspergillus species. Mycoses 2003; 46: 77-83.
33. Romani L. Immunity to fungal infections. Nat Rev Immunol 2004; 4: 1-23.
34. Sun Y, Tawara I, Toubai T, Reddy P. Pathophysiology of acute graft-versus-host disease: Recent advances. Transl Res 2007; 150: 197-214.
35. Koehne G, Smith KM, Ferguson TL, et al. Quantitation, selection, and functional characterization of Epstein-Barr virusspecific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors. Blood 2002; 99 1730-1740.
36. Ferrara JL, Cooke KR, Teshima T. The pathophysiology of acute graft-versus-host disease. Int J Hematol 2003; 78: 181-187.