메뉴 건너뛰기




Volumn 92, Issue 2, 2009, Pages 653-659

CYP11A1 and CYP17 promoter polymorphisms associate with hyperandrogenemia in polycystic ovary syndrome

Author keywords

CYP11A1; CYP17; hyperandrogenemia; PCOS

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; HYDROXYPROGESTERONE; PRASTERONE SULFATE; TESTOSTERONE;

EID: 67651097796     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.07.016     Document Type: Article
Times cited : (63)

References (40)
  • 1
    • 0026708726 scopus 로고
    • How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?
    • Clayton R., Ogden V., Hodgkinson J., Worswick L., Rodin D., Dyer S., et al. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?. Clin Endocrinol (Oxf) 37 (1992) 127-134
    • (1992) Clin Endocrinol (Oxf) , vol.37 , pp. 127-134
    • Clayton, R.1    Ogden, V.2    Hodgkinson, J.3    Worswick, L.4    Rodin, D.5    Dyer, S.6
  • 2
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S. Polycystic ovary syndrome. N Engl J Med 333 (1995) 853-861
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 3
    • 0023879442 scopus 로고
    • Polycystic ovaries a common finding in normal women
    • Polson D.W., Adams J., Wadsworth J., and Franks S. Polycystic ovaries a common finding in normal women. Lancet 8590 (1988) 870-872
    • (1988) Lancet , vol.8590 , pp. 870-872
    • Polson, D.W.1    Adams, J.2    Wadsworth, J.3    Franks, S.4
  • 4
    • 0033304888 scopus 로고    scopus 로고
    • Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women
    • Carmina E., and Lobo R.A. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 84 (1999) 1879-1899
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1879-1899
    • Carmina, E.1    Lobo, R.A.2
  • 6
    • 0024542647 scopus 로고
    • Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients
    • Conway G.S., Honour J.W., and Jacob H.S. Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clin Endocrinol (Oxf) 30 (1989) 459-470
    • (1989) Clin Endocrinol (Oxf) , vol.30 , pp. 459-470
    • Conway, G.S.1    Honour, J.W.2    Jacob, H.S.3
  • 7
    • 0035145232 scopus 로고    scopus 로고
    • Polycystic ovarian disease: heritability and heterogeneity
    • Crosignani P.G., and Nicolosi A.G. Polycystic ovarian disease: heritability and heterogeneity. Hum Reprod Update 7 (2001) 3-7
    • (2001) Hum Reprod Update , vol.7 , pp. 3-7
    • Crosignani, P.G.1    Nicolosi, A.G.2
  • 8
  • 9
    • 0018606011 scopus 로고
    • The inheritance of polycystic ovarian disease and a possible relationship to premature balding
    • Ferriman D., and Purdie A.W. The inheritance of polycystic ovarian disease and a possible relationship to premature balding. Clin Endocrinol (Oxf) 11 (1979) 291-300
    • (1979) Clin Endocrinol (Oxf) , vol.11 , pp. 291-300
    • Ferriman, D.1    Purdie, A.W.2
  • 10
    • 0024241084 scopus 로고
    • Familial polycystic ovarian disease
    • Givens J.R. Familial polycystic ovarian disease. Endocrinol Metab Clin North Am 17 (1988) 771-783
    • (1988) Endocrinol Metab Clin North Am , vol.17 , pp. 771-783
    • Givens, J.R.1
  • 15
    • 0032944019 scopus 로고    scopus 로고
    • Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families
    • Govind A., Obhrai M.S., and Clayton R.N. Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J Clin Endocrinol Metab 84 (1999) 38-43
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 38-43
    • Govind, A.1    Obhrai, M.S.2    Clayton, R.N.3
  • 16
    • 0035158107 scopus 로고    scopus 로고
    • Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS
    • Kahsar-Miller M.D., Nixon C., Boots L.R., Go R.C., and Azziz R. Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS. Fertil Steril 75 (2001) 53-58
    • (2001) Fertil Steril , vol.75 , pp. 53-58
    • Kahsar-Miller, M.D.1    Nixon, C.2    Boots, L.R.3    Go, R.C.4    Azziz, R.5
  • 17
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group
    • The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 18
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group
    • The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Fertil Steril 81 (2004) 19-25
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 20
    • 0035698276 scopus 로고    scopus 로고
    • Dyslipidemia with particular regard to apolipoprotein profile in association with polycystic ovary syndrome: a study among Indian women
    • Maitra A., Pingle R., Menon P., Gokral J., and Meherji P. Dyslipidemia with particular regard to apolipoprotein profile in association with polycystic ovary syndrome: a study among Indian women. Int J Fertil Womens Med 46 (2001) 271-277
    • (2001) Int J Fertil Womens Med , vol.46 , pp. 271-277
    • Maitra, A.1    Pingle, R.2    Menon, P.3    Gokral, J.4    Meherji, P.5
  • 21
    • 21244500111 scopus 로고    scopus 로고
    • Androgen excess in fetal programming of female reproduction: a developmental etiology for polycystic ovary syndrome?
    • Abbott D., Barnett D., Bruns C., and Dumesic D. Androgen excess in fetal programming of female reproduction: a developmental etiology for polycystic ovary syndrome?. Hum Reprod Update 11 (2005) 357-374
    • (2005) Hum Reprod Update , vol.11 , pp. 357-374
    • Abbott, D.1    Barnett, D.2    Bruns, C.3    Dumesic, D.4
  • 22
    • 0033304623 scopus 로고    scopus 로고
    • Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries
    • Nelson V.L., Legro R.S., Strauss III J.F., and McAllister J.M. Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endocrinol 13 (1999) 946-957
    • (1999) Mol Endocrinol , vol.13 , pp. 946-957
    • Nelson, V.L.1    Legro, R.S.2    Strauss III, J.F.3    McAllister, J.M.4
  • 23
    • 0033587746 scopus 로고    scopus 로고
    • Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin
    • Urbanek M., Legro R., Driscoll D., Azziz R., Ehrmann D., Norman R., et al. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Nat Acad Sci USA 96 (1999) 8573-8578
    • (1999) Proc Nat Acad Sci USA , vol.96 , pp. 8573-8578
    • Urbanek, M.1    Legro, R.2    Driscoll, D.3    Azziz, R.4    Ehrmann, D.5    Norman, R.6
  • 24
    • 0031049755 scopus 로고    scopus 로고
    • Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism
    • Gharani N., Waterworth D.M., Batty S., White D., Gilling-Smith C., Conway G.S., et al. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Hum Mol Genet 6 (1997) 397-402
    • (1997) Hum Mol Genet , vol.6 , pp. 397-402
    • Gharani, N.1    Waterworth, D.M.2    Batty, S.3    White, D.4    Gilling-Smith, C.5    Conway, G.S.6
  • 25
    • 0025195368 scopus 로고
    • Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovarian syndrome
    • Rosenfield R.L., Barnes R.B., Cara J.F., and Lucky A.W. Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovarian syndrome. Fertil Steril 53 (1990) 785-791
    • (1990) Fertil Steril , vol.53 , pp. 785-791
    • Rosenfield, R.L.1    Barnes, R.B.2    Cara, J.F.3    Lucky, A.W.4
  • 26
    • 0026664328 scopus 로고
    • Detection of functional ovarian hyperandrogenism in women with androgen excess
    • Ehrmann D.A., Rosenfield R.L., Barnes R.B., Brigell D.F., and Sheikh Z. Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med 327 (1992) 157-162
    • (1992) N Engl J Med , vol.327 , pp. 157-162
    • Ehrmann, D.A.1    Rosenfield, R.L.2    Barnes, R.B.3    Brigell, D.F.4    Sheikh, Z.5
  • 27
    • 0034457443 scopus 로고    scopus 로고
    • Differential activity of the cytochrome P450 17alpha-hydroxylase and steroid acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells
    • Wickenheisser J.K., Quinn P.G., Nelson V.L., Legro R.S., Strauss III J.F., and McAllister J.M. Differential activity of the cytochrome P450 17alpha-hydroxylase and steroid acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. J Clin Endocrinol Metab 85 (2000) 2304-2311
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2304-2311
    • Wickenheisser, J.K.1    Quinn, P.G.2    Nelson, V.L.3    Legro, R.S.4    Strauss III, J.F.5    McAllister, J.M.6
  • 28
    • 0028024363 scopus 로고
    • Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
    • Carey A.H., Waterworth D., Patel K., White D., Little J., Novelli P., et al. Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum Mol Genet 3 (1994) 1873-1876
    • (1994) Hum Mol Genet , vol.3 , pp. 1873-1876
    • Carey, A.H.1    Waterworth, D.2    Patel, K.3    White, D.4    Little, J.5    Novelli, P.6
  • 29
    • 0030988978 scopus 로고    scopus 로고
    • Frequency of a polymorphism in the regulatory region of the 17 alpha-hydroxylase-17, 20-lyase (CYP17) gene in hyperandrogenic states
    • Techatraisak K., Conway G.S., and Rumsby G. Frequency of a polymorphism in the regulatory region of the 17 alpha-hydroxylase-17, 20-lyase (CYP17) gene in hyperandrogenic states. Clin Endocrinol (Oxf) 46 (1997) 131-134
    • (1997) Clin Endocrinol (Oxf) , vol.46 , pp. 131-134
    • Techatraisak, K.1    Conway, G.S.2    Rumsby, G.3
  • 31
    • 0034061052 scopus 로고    scopus 로고
    • Microsatellite polymorphism (tttta)(n) at -528 bp of gene CYP11alpha influences hyperandrogenemia in patients with polycystic ovary syndrome
    • Diamanti-Kandarakis E., Bartzis M.I., Bergiele A.T., Tsianateli T.C., and Kouli C.R. Microsatellite polymorphism (tttta)(n) at -528 bp of gene CYP11alpha influences hyperandrogenemia in patients with polycystic ovary syndrome. Fertil Steril 73 (2000) 735-741
    • (2000) Fertil Steril , vol.73 , pp. 735-741
    • Diamanti-Kandarakis, E.1    Bartzis, M.I.2    Bergiele, A.T.3    Tsianateli, T.C.4    Kouli, C.R.5
  • 32
    • 67651088944 scopus 로고    scopus 로고
    • Mutational analysis of CYP11A1 and leptin as genetic determinants of hyperandrogenicity and obesity in PCOS: study in an Indian cohort group
    • Maitra A., Pusalkar M., Gokral J., and Meherji P. Mutational analysis of CYP11A1 and leptin as genetic determinants of hyperandrogenicity and obesity in PCOS: study in an Indian cohort group. International Congress Series 1271 (2004) 38-41
    • (2004) International Congress Series , vol.1271 , pp. 38-41
    • Maitra, A.1    Pusalkar, M.2    Gokral, J.3    Meherji, P.4
  • 33
    • 0035059718 scopus 로고    scopus 로고
    • Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism
    • San Millian J.L., Sancho J., Calvo R.M., and Escobar-Morreale H.F. Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism. Fertil Steril 75 (2001) 797-802
    • (2001) Fertil Steril , vol.75 , pp. 797-802
    • San Millian, J.L.1    Sancho, J.2    Calvo, R.M.3    Escobar-Morreale, H.F.4
  • 34
    • 0036147995 scopus 로고    scopus 로고
    • Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17 alpha-hydroxylase/C (17-20) lyase promoters
    • Daneshmand S., Weitsman S., Navab A., Jakimiuk A., and Magiffin D. Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17 alpha-hydroxylase/C (17-20) lyase promoters. Fertil Steril 77 (2002) 274-280
    • (2002) Fertil Steril , vol.77 , pp. 274-280
    • Daneshmand, S.1    Weitsman, S.2    Navab, A.3    Jakimiuk, A.4    Magiffin, D.5
  • 35
    • 2442625282 scopus 로고    scopus 로고
    • Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome and serum testosterone
    • Gaasenbeek M., Powell B., Sovio U., Haddad L., Gharani N., Bennett A., et al. Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome and serum testosterone. J Clin Endocrinol Metab 89 (2004) 2408-2413
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2408-2413
    • Gaasenbeek, M.1    Powell, B.2    Sovio, U.3    Haddad, L.4    Gharani, N.5    Bennett, A.6
  • 36
    • 33745501749 scopus 로고    scopus 로고
    • A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome
    • Wang Y., Wu X., Cao Y., Yi L., and Chen J. A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome. Fertil Steril 86 (2006) 223-226
    • (2006) Fertil Steril , vol.86 , pp. 223-226
    • Wang, Y.1    Wu, X.2    Cao, Y.3    Yi, L.4    Chen, J.5
  • 38
    • 37549034291 scopus 로고    scopus 로고
    • Deciphering the cis- regulatory elements of co-expressed genes in PCOS by in silico analysis
    • Sarkar C., and Maitra A. Deciphering the cis- regulatory elements of co-expressed genes in PCOS by in silico analysis. Gene 408 (2008) 72-84
    • (2008) Gene , vol.408 , pp. 72-84
    • Sarkar, C.1    Maitra, A.2
  • 39
    • 0038374441 scopus 로고    scopus 로고
    • The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis
    • Wood J., Nelson V., Ho C., Jansen E., Wang C., Urbanek M., et al. The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. J Biol Chem 278 (2003) 26380-26390
    • (2003) J Biol Chem , vol.278 , pp. 26380-26390
    • Wood, J.1    Nelson, V.2    Ho, C.3    Jansen, E.4    Wang, C.5    Urbanek, M.6
  • 40
    • 17144441907 scopus 로고    scopus 로고
    • GATA-4 and GATA-6 modulate tissue specific transcription of the human gene for P450c17 by direct interaction with SP1
    • Fluck C., and Miller W. GATA-4 and GATA-6 modulate tissue specific transcription of the human gene for P450c17 by direct interaction with SP1. Mol Endocrinol 18 (2004) 1144-1157
    • (2004) Mol Endocrinol , vol.18 , pp. 1144-1157
    • Fluck, C.1    Miller, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.