Increased intragastric pressure gradients are involved in the occurrence of acid reflux in gastroesophageal reflux disease

Scandinavian Journal of Gastroenterology

Volumn 44, Issue 5, 2009, Pages 545-550

  Frankhuisen, Rutger ^a   Van Herwaarden, Margot A ^b   Scheffer, Robert Ch ^a   Hebbard, Geoffrey S ^c   Gooszen, Hein G ^a   Samsom, Melvin ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DEVENTER HOSPITAL   (Netherlands)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

GERD; Intragastric pressure; Pressure gradient; TLESR

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; GASTROESOPHAGEAL REFLUX; HUMAN; LOWER ESOPHAGUS SPHINCTER; LOWER ESOPHAGUS SPHINCTER PRESSURE; MANOMETRY; MEAL; POSTPRANDIAL STATE; PRIORITY JOURNAL; STOMACH PH; STOMACH PRESSURE; AGED; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; COMPARATIVE STUDY; ESOPHAGEAL PH MONITORING; FEMALE; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSURE; PROBABILITY; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; STOMACH ACID;

ADULT; AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; ESOPHAGEAL PH MONITORING; ESOPHAGEAL SPHINCTER, LOWER; ESOPHAGOGASTRIC JUNCTION; FEMALE; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MANOMETRY; MIDDLE AGED; MUSCLE RELAXATION; PRESSURE; PROBABILITY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 67651092354     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520902718903     Document Type: Article

References (21)

1. Dent J, Dodds WJ, Friedman RH, Sekiguchi T, Hogan WJ, Arndorfer RC, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980;65:256-67.
2. Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastro-oesophageal reflux. Gut 1988;29: 1020-8.
3. Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 1982;307:1547-52.
4. Mittal RK, McCallum RW Characteristics and frequency of transient relaxations of the lower esophageal sphincter in patients with reflux esophagitis. Gastroenterology 1988;95: 593-9.
5. Schoeman MN, Tippett MD, Akkermans LM, Dent J, Holloway RH. Mechanisms of gastroesophageal reflux in ambulant healthy human subjects. Gastroenterology 1995; 108:83-91.
6. Sifrim D, Holloway R. Transient lower esophageal sphincter relaxations: how many or how harmful? Am J Gastroenterol 2001;96:2529-32.
7. Scheffer RC, Gooszen HG, Hebbard GS, Samsom M. The role of transsphincteric pressure and proximal gastric volume in acid reflux before and after fundoplication. Gastroenterology 2005;129:1900-9.
8. Pandolfino JE, Zhang QG, Ghosh SK, Han A, Boniquit C, Kahrilas PJ. Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry. Gastroenterology 2006;131:1725-33.
9. Trudgill NJ, Riley SA. Transient lower esophageal sphincter relaxations are no more frequent in patients with gastroesophageal reflux disease than in asymptomatic volunteers. Am J Gastroenterol 2001;96:2569-74.
10. Sifrim D, Holloway R, Silny J, Tack J, Lerut A, Janssens J. Composition of the postprandial refluxate in patients with gastroesophageal reflux disease. Am J Gastroenterol 2001; 96:647-55.
11. Weusten BL, Roelofs JM, Akkermans LM, Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 1994;107:1741-5.
12. Clouse RE, Staiano A, Alrakawi A. Development of a topographic analysis system for manometric studies in the gastrointestinal tract. Gastrointest Endosc 1998;48: 395-401.
13. Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995;268:G128-33.
14. Scheffer RC, Wassenaar EB, Herwaarden MA, Holloway RH, Samsom M, Smout AJ, et al. Relationship between the mechanism of gastro-oesophageal reflux and oesophageal acid exposure in patients with reflux disease. Neurogastroenterol Motil 2005;17:654-62.
15. Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 2006;130:639-49.
16. Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology 2000;118:688-95.
17. van Herwaarden MA, Samsom M, Smout AJ. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000;119:1439-46.
18. Bredenoord AJ, Weusten BL, Timmer R, Smout AJ. Intermittent spatial separation of diaphragm and lower esophageal sphincter favors acidic and weakly acidic reflux. Gastroenterology 2006;130:334-40.
19. Tefera S, Gilja OH, Olafsdottir E, Hausken T, Hatlebakk JG, Berstad A. Intragastric maldistribution of a liquid meal in patients with reflux oesophagitis assessed by three dimensional ultrasonography. Gut 2002;50:153-8.
20. Penagini R, Hebbard G, Horowitz M, Dent J, Bermingham H, Jones K, et al. Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease. Gut 1998;42:251-7.
21. Gonlachanvit S, Maurer AH, Fisher RS, Parkman HP. Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 2006;18:894-904.