Intestinal ischaemia/reperfusion upregulates β-defensin-2 expression and causes acute lung injury in the rat

Injury

Volumn 40, Issue 9, 2009, Pages 950-955

  Liu, Ke Xuan ^a   Chen, Shu Qing ^a   Zhang, Hui ^a   Guo, Jun ying ^a   Li, Yun Sheng ^a   Huang, Wen Qi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Defensin 2; Intestine; Lung injury; Reperfusion injury

Indexed keywords

BETA DEFENSIN 2; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; HISTOPATHOLOGY; INTESTINE ISCHEMIA; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERIOR MESENTERIC ARTERY; UPREGULATION; WESTERN BLOTTING;

ACUTE LUNG INJURY; ANIMALS; BETA-DEFENSINS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; INTESTINES; LIGATION; LUNG; MALE; MESENTERIC ARTERY, SUPERIOR; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 67651089698     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2009.01.103     Document Type: Article

References (22)

1. Bals R., Wang X., Wu Z., et al. Human β-defensin 2 is a salt-sensitive peptide antibiotic expression in human lung. J Clin Invest 102 (1998) 874-880
2. Caty M.G., Guice K.S., Oldham K.T., et al. Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia-reperfusion injury. Ann Surg 212 (1990) 694-700
3. Deitch E.A. Role of the gut in multiple system organ failure. Curr Opin Crit Care 7 (2001) 92-98
4. Diamond G., Kaiser V., Rhodes J., et al. Transcription regulation of beta-defensin gene expression in tracheal epithetial cells. Infect Immun 68 (2000) 113-119
5. Harder J., Bartels J., Chritophers E., et al. A peptide antibiotic from human skin. Nature 387 (1997) 861-862
6. Harder J., Meyer-Hoffert U., Teran L.M., et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1 beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 22 (2000) 714-721
7. Haskó G., Xu D.Z., Lu Q., et al. Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock. Crit Care Med 34 (2006) 1119-1125
8. Hiratsuka T., Mukae H., and Iiboshi H. Increased concentrations of human beta defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. Thorax 58 (2003) 425-430
9. Hiratsuka T., Nakazato M., Date Y., et al. Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 249 (1998) 943-947
10. Homer-Vanniasinkam S., Crinnion J.N., and Gough M.J. Post-ischaemic organ dysfunction: a review. Eur J Vasc Endovasc Surg 14 (1997) 195-203
11. Jia H.P., Mills J.N., Barahmand-Pour F., et al. Molecular cloning and characterization of rat gene coding homologues of human β-defensins. Infect Immun 67 (1999) 4827-4832
12. Liu K.X., Rinne T., He W., et al. Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. Can J Anesth 54 (2007) 366-374
13. Liu K.X., Wu W.K., He W., et al. Ginkgo biloba extract EGb 761 attenuates lung injury induced by intestinal ischemia/reperfusion in rats: roles of oxidative stress and nitric oxide. World J Gastroenterol 13 (2007) 299-305
14. Mitsuoka H., Kistler E.B., and Schmid-Schonbein G.W. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. Shock 17 (2002) 205-209
15. Mura M., Andrade C.F., Han B., et al. Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs. Shock 28 (2007) 227-238
16. Pompermayer K., Amaral F.A., Fagundes C.T., et al. Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury. Eur J Pharmacol 556 (2007) 215-222
17. Shu Q., Shi Z., Zhao Z.Y., et al. Protection against Pseudomonas aeruginosa pneumonia and sepsis-induced lung injury by overexpression of β-defensin-2 in rats. Shock 26 (2006) 365-371
18. Sorkine P., Setton A., Halpern P., et al. Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration. Crit Care Med 23 (1995) 1377-1381
19. Teke Z., Sacar M., Yenisey C., et al. Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model. Am J Surg 195 (2008) 861-873
20. Tsutsumi-Ishii Y., and Nagaoka I. Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol 170 (2003) 4226-4236
21. Turnage R.H., Guice K.S., and Oldham K.T. Pulmonary microvascular injury following intestinal reperfusion. New Horiz 2 (1994) 463-475
22. Yang D., Chertov O., Bykovskaia S.N., et al. β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286 (1999) 525-528