Progress of tissue injury in appendicitis involves the serine proteases uPA and PAI-1

Scandinavian Journal of Gastroenterology

Volumn 44, Issue 5, 2009, Pages 579-584

  Solberg, Anna ^a,b   Holmdahl, Lena ^b   Falk, Peter ^b   Willen, Roger ^c   Palmgren, Ingrid ^b   Ivarsson, Marie Louise ^b,d  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d Kungsbacka Hospital   (Sweden)

Author keywords

Appendicitis; Inflammation; MMPs; PAI 1; Perforation; UPA

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE; AUTACOID; MESSENGER RNA; SERINE PROTEINASE;

APPENDICITIS; APPENDIX PERFORATION; ARTICLE; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; EXTRACELLULAR MATRIX; FEMALE; GANGRENOUS APPENDICITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PHLEGMONOUS APPENDICITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE INJURY; VASCULAR ENDOTHELIUM; ADULT; APPENDECTOMY; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; DISEASE COURSE; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; HOSPITALIZATION; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; NEEDLE BIOPSY; NONPARAMETRIC TEST; PATHOLOGY; PROBABILITY; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ADULT; APPENDECTOMY; APPENDICITIS; BIOPSY, NEEDLE; CASE-CONTROL STUDIES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROBABILITY; REFERENCE VALUES; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SERINE ENDOPEPTIDASES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; YOUNG ADULT;

EID: 67651085574     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520802699286     Document Type: Article

References (41)

1. Carr NJ. The pathology of acute appendicitis. Ann Diagn Pathol 2000;4:46.
2. Humes DJ, Simpson J. Acute appendicitis. Br Med J 2006; 333:530.
3. Marudanayagam R, Williams GT, Rees BI. Review of the pathological results of 2660 appendicectomy specimens. J Gastroenterol 2006;41:745.
4. Pieper R, Kager L, Tidefeldt U. Obstruction of appendix vermiformis causing acute appendicitis. An experimental study in the rabbit. Acta Chir Scand 1982;148:63.
5. Arnbjornsson E, Bengmark S. Obstruction of the appendix lumen in relation to pathogenesis of acute appendicitis. Acta Chir Scand 1983;149:789.
6. Ebram-Neto J, Celano RM, Lanzoni VF, Juliano Y, Novo NF, Canduro AB, et al. Acute appendicitis. Experimental model in rabbits. Arq Gastroenterol 2000;37:114.
7. Arnbjornsson E, Bengmark S. Role of obstruction in the pathogenesis of acute appendicitis. Am J Surg 1984;147:390.
8. Korner H, Sondenaa K, Soreide JA, Andersen E, Nystad A, Lende the, et al. Incidence of acute nonperforated and perforated appendicitis: age-specific and sex-specific analysis. World J Surg 1997;21:313.
9. Korner H, Sondenaa K, Soreide JA. Perforated and non-perforated acute appendicitis: one disease or two entities? Eur J Surg 2001;167:525.
10. Luckmann R. Incidence and case fatality rates for acute appendicitis in California. A population-based study of the effects of age. Am J Epidemiol 1989;129:905.
11. Andersson R, Hugander A, Thulin A, Nyström PO, Olaison G. Indications for operation in suspected appendicitis and incidence of perforation. Br Med J 1994;308:107.
12. Kraemer M, Kremer K, Leppert R, Yang Q, Ohman C, Fuchs KH. Perforating appendicitis: is it a separate disease? The Acute Abdominal Pain Study Group. Eur J Surg 1999; 165:473.
13. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg 2007;245:886.
14. Solberg A, Holmdahl L, Falk P, Palmgren I, Ivarsson M-L. A local imbalance between MMP and TIMP may have an implication on the severity and course of appendicitis. Int J Colorectal Dis 2008;23:611.
15. Levi M, van der Poll T. Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005;15:254.
16. Grondahl-Hansen J, Kirkeby LT, Ralfkiaer E, Kristensen P, Lund LR, Dano K. Urokinase-type plasminogen activator in endothelial cells during acute inflammation of the appendix. Am J Pathol 1989;135:631.
17. Whawell SA, Wang Y, Fleming KA, Thompson EM, Thompson JN. Localization of plasminogen activator inhibitor-1 production in inflamed appendix by in situ mRNA hybridization. J Pathol 1993;169:67.
18. Whawell SA, Thompson JN. Cytokine-induced release of plasminogen activator inhibitor-1 by human mesothelial cells. Eur J Surg 1995;161:315.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265.
20. Soreide K. Proteinase-activated receptor 2 (PAR-2) in gastrointestinal and pancreatic pathophysiology, inflammation and neoplasia. Scand J Gastroenterol 2008;43:902.
21. Binder BR, Mihaly J, Prager GW uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. Thromb Haemost 2007;97:336.
22. Schmitt M, Wilhelm OG, Reuning U, Krüger A, Harbeck N, Lengyel E, et al. The urokinase plasminogen activator system as a novel target for tumour therapy. Fibrinol Proteol 2000;14:114.
23. Schouten M, Wiersinga WJ, Levi M, van der Poll T Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 2008;83:536.
24. van der Poll T, Levi M, Buller HR, van Deventer SJ, deBoer JP, Hack CE, et al. Fibrinolytic response to tumor necrosis factor in healthy subjects. J Exp Med 1991;174:729.
25. Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y. The plasminogen activator system: biology and regulation. Cell Mol Life Sci 1999;56:104.
26. Degryse B, Sier CF, Resnati M, Conese M, Blasi F. PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor. FEBS Lett 2001;505:249.
27. Mondino A, Blasi F uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol 2004;25:450.
28. Kwak SH, Mitra S, Bdeir K, Strassheim D, Park JS, Kim JY, et al. The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins. J Leukocyte Biol 2005;78:937.
29. Kwak SH, Wang XQ, He Q, Fang WF, Mitra S, Bdeir K, et al. Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway. Thromb Haemost 2006;95:829.
30. Ivarsson ML, Holmdahl L, Falk P, Molne J, Risberg B. Characterization and fibrinolytic properties of mesothelial cells isolated from peritoneal lavage. Scand J Clin Lab Invest 1998;58:195.
31. Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D, Jern S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood 2004;104:3943.
32. Senno SL, Pechet L. Clinical implications of elevated PAI-1 revisited: multiple arterial thrombosis in a patient with essential thrombocythemia and elevated plasminogen activator inhibitor-1 (PAI-1) levels: a case report and review of the literature. J Thromb Thrombolysis 1999;8:105-12.
33. Incesu L, Yazicioglu AK, Selcuk MB, Ozen N. Contrast-enhanced power Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 2004;50:201.
34. Patriquin HB, Garcier JM, Lafortune M, Yazbeck S, russo P, Jequier P, et al. Appendicitis in children and young adults: Doppler sonographic-pathologic correlation. AJR Am J Roentgenol 1996;166:629.
35. Nunes FC, Silva AL. Acute ischaemic appendicitis in rabbits: new model with histopathological study. Acta Chir Bras 2005;20:399.
36. de Jong E, Porte RJ, Knot EA, Verheijer JH, Dees J. Disturbed fibrinolysis in patients with inflammatory bowel disease. A study in blood plasma, colon mucosa, and faeces. Gut 1989;30:188.
37. Koutroubakis IE, Sfiridaki A, Tsiolakidou G, Coucoutsi C, Theodoropoulou A, Kouroumalis EA. Plasma thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 levels in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2008;20:912.
38. Danese S, Papa A, Saibeni S, Repiei A, Malesci A, Vecchi M. Inflammation and coagulation in inflammatory bowel disease: the clot thickens. Am J Gastroenterol 2006;1.13.
39. Miseljic S, Galandiuk S, Myers SD, Wittliff JL. Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. J Clin Lab Anal 1995;9: 413.
40. Sans M, Tassies D, Pellise M, Espinosa G, Quint? L, Piqué JM, et al. The 4G/4G genotype of the 4G/5G polymorphism of the type-1 plasminogen activator inhibitor (PAI-1) gene is a determinant of penetrating behaviour in patients with Crohn's disease. Aliment Pharmacol Ther 2003;17:1039.
41. Dhillon AP, Anthony A, Sim R, Wakefield AJ, Sankey EA, Hudson M, et al. Mucosal capillary thrombi in rectal biopsies. Histopathology 1992;21:127.