High rate of misclassification of treatment failure based on WHO immunological criteria

AIDS

Volumn 23, Issue 10, 2009, Pages 1295-1296

  Castelnuovo, Barbara ^a   Kiragga, Agnes ^b   Schaefer, Petra ^b   Kambugu, Andrew ^b   Manabe, Yukari ^b  

^a MULAGO HOSPITAL   (Uganda)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; NEVIRAPINE;

ADULT; ANTIVIRAL THERAPY; CD4+ CD25+ T LYMPHOCYTE; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIROLOGY; VIRUS LOAD; WORLD HEALTH ORGANIZATION;

ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; DRUG MONITORING; HIV INFECTIONS; HIV-1; HUMANS; TREATMENT FAILURE;

EID: 67651064706     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32832cbd43     Document Type: Letter

References (4)

1. Reynolds S, Nakigozi G, Newell K, Ndyanabo A, Galiwongo R, Boaz I, et al. Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda. AIDS 2009; 23:697-700.
2. WHO. Antiretroviral therapy for HIV infection in adults and adolescents in resource-limited settings: towards universal access. Geneva: WHO; 2006. http://www.who.int/hiv/pub/guidelines/art/en/index.html. [Accessed 5 February 2009]
3. Moore DM, Mermin J, Awor A, Yip B, Hogg RS, Montaner JS. Performance of immunologic responses in predicting viral load suppression: implications for monitoring patients in resource limited settings. J Acquir Immune Defic Syndr 2006; 43:436-439.
4. Mee P, Fielding KL, Charalambous S, Churchyard GJ, Grant AD. Evaluation of the WHO criteria for antiretroviral treatment failure among adults in South Africa. AIDS 2008; 22:1971-1977.