Cyclosporine A prevents vascular hyperpermeability after hemorrhagic shock by inhibiting apoptotic signaling

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 4, 2009, Pages 1033-1039

  Tharakan, Binu ^a   Holder Haynes, Juliet G ^a   Hunter, Felicia A ^a   Smythe, W Roy ^a   Childs, Ed W ^a  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Apoptosis; Caspase 3; Cytochrome c; Hemorrhagic shock; Vascular permeability

Indexed keywords

CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; CYCLOSPORIN; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL ADHESION; CELL JUNCTION; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRAVASATION; HEMORRHAGIC SHOCK; ILEUM; MALE; MESENTERIC VEIN; MESENTERY BLOOD VESSEL; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VENULE; ANIMAL; CAPILLARY PERMEABILITY; FLUOROMETRY; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CAPILLARY PERMEABILITY; CASPASE 3; CYCLOSPORINE; CYTOCHROMES C; CYTOSOL; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FLUOROMETRY; MALE; MITOCHONDRIA; RATS; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; VENULES;

EID: 67651053003     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31816c905f     Document Type: Article

References (29)

1. Baluk P, Hirata A, Thurston G, et al. Endothelial gaps: time course of formation and closure in inflamed venules of rats. Am J Physiol. 1997;272:L155-L170. (Pubitemid 27073956)
2. Childs EW, Udobi KF, Hunter FA, Dhevan V. Evidence of transcellular albumin transport after hemorrhagic shock. Shock. 2005;23:565-570. (Pubitemid 40677431)
3. McDonald DM. Endothelial gaps: plasma leakage during inflammation. News Physiol Sci. 1998;13:104-105.
4. Davidson MT, Deitch EA, Lu Q, et al. Trauma-hemorrhagic shock mesenteric lymph induces endothelial apoptosis that involves both caspase-dependent and caspase-independent mechanisms. Ann Surg. 2004;240:123-131. (Pubitemid 38808244)
5. Mauriz JL, Gonzalez P, Jorquera F, et al. Caspase inhibition does not protect against liver damage in hemorrhagic shock. Shock. 2003;19:33-37.
6. Murao Y, Hata M, Ohnishi K, et al. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003;20:23-28.
7. Watts JA, Grattan RM II, Whitlow BS, Kline JA. Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2001;281:498-506.
8. Honda HM, Korge P, Weiss JN. Mitochondria and ischemia/reperfusion injury. Ann N Y Acad Sci. 2005;1047:248-258.
9. Kim R, Emi M, Tanabe K. Caspase-dependent and -independent cell death pathways after DNA damage. Oncol Rep. 2005;14:595-599.
10. Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2007;292:H3179-H189. (Pubitemid 47084574)
11. Brancolini C, Lazarevic D, Rodriguez J, Schneider C. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J Cell Biol. 1997;139:759-771. (Pubitemid 27485840)
12. Herren B, Levkau B, Raines EW, Ross R. Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell. 1998;9:1589-1601. (Pubitemid 28303499)
13. Bannerman DD, Sathyamoorthy M, Goldblum SE. Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins. J Biol Chem. 1998;273:35371-35380. (Pubitemid 29028247)
14. Walter DH, Haendeler J, Galle J, Zeiher AM, Dimmeler S. Cyclosporine A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation. 1998;98:1153-1157. (Pubitemid 28436163)
15. Armstrong JS, Yang H, Duan W, Whiteman M. Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways. J Biol Chem. 2004;279:50420-50428. (Pubitemid 39577860)
16. Halestrap AP, Connern CP, Griffiths EJ, Kerr PM. Cyclosporine A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem. 1997;174:167-172.
17. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun. 2003;304:433-435.
18. McStay GP, Clarke SJ, Halestrap AP. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J. 2002;367:541-548.
19. Halestrap AP, Brennerb C. The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem. 2003;10:1507-1525.
20. Garrido C, Galluzi L, Brunet M, Puig PE, Didelot C, Kroemer G. Mechanism of cytochrome c release from mitochondria. Cell Death Diff. 2006;13:1423-1433.
21. Gregorc U, Ivanova S, Thomas M, Turk V, Banks L, Turk B. hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis. Biol Chem. 2005;386:705-710. (Pubitemid 41448173)
22. Hunter I, McGregor D, Robins SP. Caspase-dependent cleavage of cadherins and catenins during osteoblast apoptosis. J Bone Miner Res. 2001;16:466-477. (Pubitemid 32173361)
23. Cattelino A, Liebner S, Gallini R, et al. The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol. 2003;162:1111-1122. (Pubitemid 37174193)
24. Cervello M, Giannitrapani L, La Rosa M, et al. Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation. Int J Mol Med. 2004;13:741-748.
25. Van de Craen M, Berx G, Van den Brande I, Fiers W, Declercq W, Vandenabeele P. Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis. FEBS Lett. 1999;458:167-170. (Pubitemid 29428176)
26. Nakamoto K, Kuratsu J, Ozawa M. Beta-catenin cleavage in nonapoptotic cells with reduced cell adhesion activity. Int J Mol Med. 2005;15:973-979.
27. Steinhusen U, Badock V, Bauer A, et al. Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem. 2000;275:16345-16353. (Pubitemid 30366951)
28. Wang H, Zhao L, Sun Z, Sun L, Zhang B, Zhao Y. A potential side effect of cyclosporine A: inhibition of CD4(+)CD25(+) regulatory T cells in mice. Transplantation. 2006;82:1484-1492. (Pubitemid 44967632)
29. Kawai M, Kitade H, Mathieu C, Waer M, Pirenne J. Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo. Transplantation. 2005;79:1073-1077. (Pubitemid 40664000)