Synchronous primary carcinoma in 5 different organs of a female genital tract: An unusual case and review of the literature

International Journal of Gynecological Cancer

Volumn 19, Issue 4, 2009, Pages 802-807

  Atasever, Melahat ^a   Yilmaz, Bulent ^b,d   Dilek, Gulay ^a   Akcay, Eda Yilmaz ^a   Kelekci, Sefa ^c  

^a ANKARA ONCOLOGY HOSPITAL   (Turkey)

^b Adana Devlet Hastanesi   (Turkey)

^c Numune Education and Research Hospital   (Turkey)

^d Camlitepe Mahallesi   (Turkey)

Author keywords

Cervical cancer; Endometrial cancer; Fallopian tube cancer; Gynecologic malignancies; Ovarian cancer; Synchronous primary tumors

Indexed keywords

CA 125 ANTIGEN; CA 15-3 ANTIGEN; CA 19-9 ANTIGEN; CISPLATIN; KI 67 ANTIGEN; PACLITAXEL; PROTEIN P53;

ABDOMINAL DISTENSION; ABDOMINAL HYSTERECTOMY; ADULT; ARTICLE; BLOOD CELL COUNT; CANCER CHEMOTHERAPY; CANCER INVASION; CARCINOMA IN SITU; CASE REPORT; COCARCINOGENESIS; COMPUTER ASSISTED TOMOGRAPHY; CYTOLOGY; DEATH; ENDOMETRIUM CARCINOMA; ESOPHAGOGASTRODUODENOSCOPY; FEMALE; FEMALE GENITAL SYSTEM; GASTRITIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; LAPAROTOMY; LUNG EMBOLISM; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY CARCINOMA; PAPANICOLAOU TEST; PAPILLARY CARCINOMA; PELVIS PAIN SYNDROME; PELVIS RADIOGRAPHY; PRIMARY TUMOR; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; SYNCHRONOUS PRIMARY CANCER; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; UTERINE TUBE CARCINOMA; VAGINITIS;

FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY;

EID: 67651046248     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/IGC.0b013e3181a39b95     Document Type: Article

References (26)

1. Ayhan A, Yalçin OT, Tuncer ZS, et al. Synchronous primary malignancies of the female genital tract. Eur J Obstet Gynecol Reprod Biol. 1992;45:63-66.
2. Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas-a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83:355-362.
3. Eisner RF, Nieberg RK, Berek JS. Synchronous primary neoplasms of the female reproductive tract. Gynecol Oncol. 1989;33:335-339.
4. Piura B, Glezerman M. Synchronous carcinomas of endometrium and ovary. Gynecol Oncol. 1989;33:261-264.
5. Russell P, Bannatyne PM, Solomon HJ, et al. Multifocal tumorigenesis in the upper female genital tract-implications for staging and management. Int J Gynecol Pathol. 1985;4:192-210.
6. Woodruff JD, Solomon D, Sullivant H. Multifocal disease in the upper genital canal. Obstet Gynecol. 1985;65:695-698.
7. Campbell JS, Magner D, FournNer P. Adenoacanthomas of ovary and uterus occurring as coexistent or sequential primary neoplasms. Cancer. 1961;14:817-826.
8. Eifel P, Hendrickson M, Ross J, et al. Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer. 1982;50:163-170.
9. Ulbright TM, Roth LM. Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol. 1985;16:28-34.
10. Rose PG, Herterick EE, Boutselis JG, et al. Multiple primary gynecologic neoplasms. Am J Obstet Gynecol. 1987;157:261-267.
11. Dockerty MB. Primary and secondary ovarian adenocanthoma. Surg Gynecol Obstet. 1954;99:392-400.
12. Zaino RJ, Unger ER, Whitney C. Synchronous carcinomas of the uterine corpus and ovary. Gynecol Oncol. 1984;19:329-335.
13. Sheu BC, Lin HH, Chen CK, et al. Synchronous primary carcinomas of the endometrium and ovary. Int J Gynaecol Obstet. 1995;51:141-146.
14. Papathanasiou K, Tolikas A, Dovas D, et al. Simultaneously detected primary malignant tumors of ovary and endometrium with unusual histology. Int J Gynecol Cancer. 2005;15:1191-1194.
15. Jaime P, Xavier M-G, Jose B. Simultaneous carcinoma involving the endometrium and ovary: a clinicopathologic, immunohistochemical, and DNA flow cytometric study of 18 cases. Cancer. 1991;68:2455-2459.
16. Scully RE, Young RH, Clement PB. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. Atlas of Tumor Pathology. Bethesda, MD: Armed Forces Institute of Pathology; 1998.
17. Prat J, Matias-Guiu X, Barreto J. Simultaneous carcinoma involving the endometrium and ovary: a clinicopathologic, immunohistochemical, and DNA flow cytometric study of 18 cases. Cancer. 1991;68: 2455-2459.
18. Prat J. Clonality analysis in synchronous tumors of the female genital tract [editorial]. Hum Pathol. 2002;33:383-385.
19. Fujii H, Matsumoto T, Yoshida M, et al. Genetics of synchronous uterine and ovarian endometrioid carcinoma: combined analyses of loss of heterozygosity, PTEN mutation, and microsatellite instability. Hum Pathol. 2002;33:421-428.
20. Ree YS, Cho SH, Kim SR, et al. Synchronous primary endometrial and ovarian cancer with three different histologic patterns: a case report. Int J Gynecol Cancer. 2003;13:678-682.
21. Woodruff JD, Julian CG. Multiple malignancy in the upper genital tract. Am J Obstet Gynecol. 1993;43:305-312.
22. Soliman PT, Slomovitz BM, Broaddus RR, et al. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases [review]. Gynecol Oncol. 2004;94:456-462.
23. Işin Doǧan Ekici A, Küçükali T, Coşkun Salman M, et al. Triple simultaneous primary gynecological malignancies in a 56-year-old patient. Int J Gynecol Cancer. 2006;16:1947-1950.
24. Barakat RR, Grigsby PW, Sabbatini P, et al. Corpus: epithelial tumors. In: Hoskins W, Perez C, Young R, eds. Principles and Practice of Gynecologic Oncology. Philadelphia, PA: Lippincott; 2000:919-960.
25. Castro IM, Connell PP, Waggoner S, et al. Synchronous ovarian and endometrial malignancies. Am J Clin Oncol. 2000;23:521-525.
26. Pearl ML, Johnston CM, Frank TS, et al. Synchronous dual primary ovarian and endometrial carcinomas. Int J Gynaecol Obstet. 1993;43:305-312.