Type 2 diabetes mellitus phenotype and graft survival after islet transplantation

Transplantation

Volumn 88, Issue 1, 2009, Pages 57-61

  Leitão, Cristiane B ^a,b   Bernetti, Karina ^a   Tharavanij, Thipaporn ^a,c   Cure, Pablo ^a   Ricordi, Camillo ^a,d   Alejandro, Rodolfo ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c THAMMASAT UNIVERSITY   (Thailand)

^d JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

Family history of type 2 diabetes; Islet transplantation; Lypotoxicity; Overweight; Type 1 diabetes

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILY HISTORY; FEMALE; GRAFT DYSFUNCTION; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TREATMENT OUTCOME; BODY MASS; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PEDIGREE; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; TIME;

ADULT; BODY MASS INDEX; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GRAFT SURVIVAL; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS TRANSPLANTATION; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; PEDIGREE; PHENOTYPE; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 67651024400     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181aa7cc2     Document Type: Article

References (17)

1. Robertson RP. Islet transplantation as a treatment for diabetes - A work in progress. New Engl J Med 2004; 350: 694.
2. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes me'llitus using a glucocorticoid-free immunosuppressive regimen. New Engl J Med 2000; 343: 230.
3. Froud T, Ricordi C, Baidal DA, et al. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant 2005; 5: 2037.
4. Hering BJ, Kandaswamy R, Ansite JD, et al. Single-donor, marginaldose islet transplantation in patients with type 1 diabetes. JAMA 2005; 293: 830.
5. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060.
6. Collaborative Islet Transplant Registry (CITR) 2008. Available at http://www.citregistry.org/. Accessed 23 July 2008.
7. Campbell PM, Salam A, Ryan EA, et al. Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation. Am J Transplant 2007; 7: 1242.
8. Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistance - The emerging role of the adipocyte as an endocrine organ. New Engl J Med 2001; 345: 1345.
9. Schulz LO, Bennett PH, Ravussin E, et al. Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care 2006; 29: 1866.
10. Dabelea D, D'Agostino RB Jr, Mayer-Davis EJ, et al. Testing the accelerator hypothesis: Body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care 2006; 29: 290.
11. Kilpatrick ES, Rigby AS, Atkin SL. Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: "double diabetes" in the Diabetes Control and Complications Trial. Diabetes Care 2007; 30: 707.
12. Mokdad AH, Bowman BA, Ford ES, et al. The continuing epidemics of obesity and diabetes in the United States. JAMA 2001; 286: 1195.
13. Gale EAM. To boldly go or to go too boldly? The accelerator hypothesis revisited. Diabetologia 2007; 50: 1571.
14. Poitout V, Robertson RP. Glucolipotoxicity: Fuel excess and beta-cell dysfunction. Endocr Rev 2008; 29: 351.
15. Lee Y, Ravazzola M, Park BH, et al. Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: Role of lipotoxicity and prevention by leptin. Diabetes 2007; 56: 2295.
16. Cunha DA, Hekerman P, Ladrière L, et al. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci 2008; 121: 2308.
17. Bhargava R, Senior PA, Ackerman TE, et al. Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes 2004; 53: 1311.