Cytoplasmic mutated nucleophosmin (NPM1) in blast crisis of chronic myeloid leukaemia

Leukemia

Volumn 23, Issue 7, 2009, Pages 1370-1371

  Piccaluga, P P ^a   Sabattini, E ^a   Bacci, F ^a   Agostinelli, C ^a   Righi, S ^a   Salmi, F ^a   Testoni, N ^a   Paolini, S ^a   Castagnetti, F ^a   Martinelli, G ^a   Falini, B ^b   Pileri, S A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CD135 ANTIGEN; MYELOPEROXIDASE; NUCLEOPHOSMIN;

AGED; ANTIBIOTIC THERAPY; BLAST CELL CRISIS; CASE REPORT; CHRONIC MYELOID LEUKEMIA; DYSERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DUPLICATION; GENE LOCATION; GENE REARRANGEMENT; GENE SEQUENCE; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LETTER; LEUKOCYTE COUNT; LUNG TUBERCULOSIS; MEGAKARYOCYTE; MYELOBLAST; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPLENOMEGALY;

EID: 67651003159     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.95     Document Type: Letter

References (9)

1. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. New Engl J Med 2005; 352: 254-266.
2. Falini B, Mecucci C, Saglio G, Lo Coco F, Diverio D, Brown P et al NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica 2008; 93 439-442.
3. Falini B, Nicoletti I, Martelli MF, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+AML): Biologic and clinical features. Blood 2007; 109: 874-885.
4. Schlenk RF, Dohner K, Krauter J, Frohling S, Corbacioglu A, Bullinger L et al. Mutations and treatment outcome in cyto-genetically normal acute myeloid leukemia. N Engl J Med 2008; 358: 1909-1918.
5. Arber D, Brunning R, Le Beau M, Falini B, Vardiman J, Porwit A et al Acute myeloid leukemia (AML) and related precursor neoplasms. In: IARC (ed). WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. Lyon, France, 2008, pp 109-145.
6. Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M et al Myeloid sarcoma: Clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 2007; 21: 340-350.
7. Pasqualucci L, Li S, Meloni G, Schnittger S, Gattenlohner S, Liso A et al. NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis: De-novo origin? Leukemia 2008; 22: 1459-1463.
8. Yin CC, Medeiros LJ, Glassman AB, Lin P. t(8;21)(q22;q22) in blast phase of chronic myelogenous leukemia. Am J Clin Pathol 2004; 121: 836-842.
9. Merzianu M, Medeiros LJ, Cortes J, Yin C, Lin P, Jones D et al. inv(16)(p13q22) in chronic myelogenous leukemia in blast phase: A clinicopathologic, cytogenetic, and molecular study of five cases. Am J Clin Pathol 2005; 124: 807-814.