Impact of hypochlorite-based disinfection on bacterial contamination of cystic fibrosis patients' home-nebulisers

Journal of Hospital Infection

Volumn 72, Issue 4, 2009, Pages 351-357

  Reychler, G ^a   Leonard, A ^a   Van Ossel, C ^a   Godding, V ^a   Gigi, J ^a   Simon, A ^a   Lebecque, P ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Aerosol; Bacterial contamination; Cystic fibrosis; Disinfection; Hygiene; Nebuliser

Indexed keywords

AMIKACIN; COLISTIN; HYPOCHLORITE; TOBRAMYCIN;

ADOLESCENT; ADULT; ARTICLE; BACTERIUM CONTAMINATION; BACTERIUM ISOLATION; CLEANING; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISINFECTION; HEALTH SURVEY; HOME CARE; HUMAN; IN VITRO STUDY; MICROBIOLOGICAL EXAMINATION; NEBULIZER; QUESTIONNAIRE; SPUTUM ANALYSIS;

ADOLESCENT; ADULT; BACTERIA; BACTERIAL INFECTIONS; CHILD; CYSTIC FIBROSIS; DISINFECTANTS; DISINFECTION; HUMANS; HYPOCHLOROUS ACID; NEBULIZERS AND VAPORIZERS; PATIENT COMPLIANCE; QUESTIONNAIRES; SPUTUM; YOUNG ADULT;

EID: 67650998475     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2009.05.011     Document Type: Article

References (33)

1. Mertz J., Scharer L., and McClement J.H. A hospital outbreak of Klebsiella pneumonia from inhalation therapy with contaminated aerosol solutions. Am Rev Respir Dis 95 (1967) 454-460
2. Takigawa K., Fujita J., Negayama K., et al. Nosocomial outbreak of Pseudomonas cepacia respiratory infection in immunocompromised patients associated with contaminated nebulizer devices. Kansenshogaku Zasshi 67 (1993) 1115-1125 (Abstract)
3. Schultsz C., Meester H., Kranenburg A., et al. Ultra-sonic nebulizers as a potential source of methicillin-resistant Staphylococcus aureus causing an outbreak in a university tertiary care hospital. J Hosp Infect 55 (2003) 269-275
4. Ringrose R., McKown B., Felton F., Barclay B., Muchmore H., and Rhoades E. A hospital outbreak of Serratia marcescens associated with ultrasonic nebulizers. Ann Intern Med 69 (1968) 719-729
5. Mastro T., Fields B., Breiman R., Campbell J., Plikaytis B., and Spika J. Nosocomial Legionnaires' disease and use of medication nebulizers. J Infect Dis 163 (1991) 667-671
6. Cobben N., Drent M., Jonkers M., Wouters E., Vaneechoutte M., and Stobberingh E. Outbreak of severe Pseudomonas aeruginosa respiratory infections due to contaminated nebulizers. J Hosp Infect 33 (1996) 63-70
7. Barnes K., Clifford R., Holgate S., Murphy D., Comber P., and Bell E. Bacterial contamination of home nebuliser. Br Med J 295 (1987) 812
8. Jones P., Moritz V., and Pierce R. Microbial contamination of domiciliary nebuliser therapy equipment. Aust N Z J Med 15 (1985) 585-589
9. Monforte V., Roman A., Gavalda J., et al. Contamination of the nebulization systems used in the prophylaxis with amphotericin B nebulized in lung transplantation. Transplant Proc 37 (2005) 4056-4058
10. Cohen H., Kahan E., Cohen Z., et al. Microbial colonization of nebulizers used by asthmatic children. Pediatr Int 48 (2006) 454-458
11. Estivariz C., Bhatti L., Pati R., et al. An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest 130 (2006) 1346-1353
12. Balkhy H., Cunningham G., Francis C., et al. A National Guard outbreak of Burkholderia cepacia infection and colonization secondary to intrinsic contamination of albuterol nebulization solution. Am J Infect Control 33 (2005) 182-188
13. Pierce A., Sanford J., Thomas G., and Leonard J. Long-term evaluation of decontamination of inhalation-therapy equipment and the occurrence of necrotizing pneumonia. N Engl J Med 282 (1970) 528-531
14. Pitchford K., Corey M., Highsmith A., et al. Pseudomonas species contamination of cystic fibrosis patients' home inhalation equipment. J Pediatr 111 (1987) 212-216
15. Hutchinson G., Parker S., Pryor J., et al. Home-use nebulizers: a potential primary source of Burkholderia cepacia and other colistin-resistant, gram-negative bacteria in patients with cystic fibrosis. J Clin Microbiol 34 (1996) 584-587
16. Jakobsson B., Onnered A., Hjelte L., and Nystrom B. Low bacterial contamination of nebulizers in home treatment of cystic fibrosis patients. J Hosp Infect 36 (1997) 201-207
17. Rosenfeld M., Emerson J., Astley S., et al. Home nebulizer use among patients with cystic fibrosis. J Pediatr 132 (1998) 125-131
18. Vassal S., Taamma R., Marty N., et al. Microbiologic contamination study of nebulizers after aerosol therapy in patients with cystic fibrosis. Am J Infect Control 28 (2000) 347-351
19. Denton M., Rajgopal A., Mooney L., et al. Stenotrophomonas maltophilia contamination of nebulizers used to deliver aerosolized therapy to inpatients with cystic fibrosis. J Hosp Infect 55 (2003) 180-183
20. Kosorok M., Jalaluddin M., Farrell P., et al. Comprehensive analysis of risk factors for acquisition of Pseudomonas aeruginosa in young children with cystic fibrosis. Pediatr Pulmonol 26 (1998) 81-88
21. Burdge D., Nakielna E., and Noble M. Case-control and vector studies of nosocomial acquisition of Pseudomonas cepacia in adult patients with cystic fibrosis. Infect Control Hosp Epidemiol 14 (1993) 127-130
22. Walsh N., Casano A., Manangan L., Sinkowitz-Cochran R., and Jarvis W.R. Risk factors for Burkholderia cepacia complex colonization and infection among patients with cystic fibrosis. J Pediatr 141 (2002) 512-517
23. Saiman L., and Siegel J. Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. Am J Infect Control 31 (2003) S1-62
24. Reychler G., Aarab K., Van Ossel C., et al. In vitro evaluation of efficacy of 5 methods of disinfection on mouthpieces and facemasks contaminated by strains of cystic fibrosis patients. J Cyst Fibros 4 (2005) 183-187
25. Blau H., Mussaffi H., Mei Zahav M., et al. Microbial contamination of nebulizers in the home treatment of cystic fibrosis. Child Care Health Dev 33 (2007) 491-495
26. Spencer R. The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia. J Hosp Infect 30 Suppl. (1995) 453-464
27. Denton M., and Kerr K. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev 11 (1998) 57-80
28. Denton M., Todd N., Kerr K., Hawkey P., and Littlewood J. Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples. J Clin Microbiol 36 (1998) 1953-1958
29. Botman M., and de Krieger R. Contamination of small-volume medication nebulizers and its association with oropharyngeal colonization. J Hosp Infect 10 (1987) 204-208
30. Wexler M., Rhame F., Blumenthal M., Cameron S., Juni B., and Fish L. Transmission of gram-negative bacilli to asthmatic children via home nebulizers. Ann Allergy 66 (1991) 267-271
31. O'Malley C.A., VandenBranden S.L., Zheng X.T., Polito A.M., and McColley S.A. A day in the life of a nebulizer: surveillance for bacterial growth in nebulizer equipment of children with cystic fibrosis in the hospital setting. Respir Care 52 (2007) 258-262
32. Lebecque P., Leal T., Zylberberg K., Reychler G., Bossuyt X., and Godding V. Towards zero prevalence of chronic Pseudomonas aeruginosa infection in children with cystic fibrosis. J Cyst Fibros 5 (2006) 237-244
33. Lee T.W., Brownlee K.G., Conway S.P., Denton M., and Littlewood J.M. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros 2 (2003) 29-34