Matrix metalloproteinases in the urine and tissue of patients with juvenile polyps: Potential biomarkers for the presence of polyps

Journal of Pediatric Gastroenterology and Nutrition

Volumn 48, Issue 4, 2009, Pages 405-411

  Manfredi, Michael A ^a   Fox, Victor L ^a   Zurakowski, David ^a   Kutok, Jeffery L ^b   Glickman, Jonathan N ^b   Moses, Marsha A ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Karp Family Research Laboratories   (United States)

Author keywords

Biomarkers; Juvenile; Juvenile polyps; Matrix metalloproteinases; Polyps

Indexed keywords

BIOLOGICAL MARKER; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE;

ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; COLON; COLONOSCOPY; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME LOCALIZATION; EPITHELIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JUVENILE POLYP; LAMINA PROPRIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION; URINALYSIS; ZYMOGRAPHY;

BIOLOGICAL MARKERS; CHILD; COLON; COLONIC POLYPS; GASTROINTESTINAL DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PILOT PROJECTS; PROSPECTIVE STUDIES; REFERENCE VALUES;

EID: 67650928175     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e318180e65b     Document Type: Article

References (37)

1. Chow E, Macrae F. A review of juvenile polyposis syndrome. J Gastroenterol Hepatol 2005;20:1634-40.
2. Coffin CM, Dehner LP. What is a juvenile polyp? An analysis based on 21 patients with solitary and multiple polyps. Arch Pathol Lab Med 1996;120:1032-8.
3. Kapetanakis AM, Vini D, Plitsis G. Solitary juvenile polyps in children and colon cancer. Hepatogastroenterology 1996;43:1530-1.
4. Merg A, Howe JR. Genetic conditions associated with intestinal juvenile polyps. Am J Med Genet C Semin Med Genet 2004; 129:44-55.
5. McColl I, Busxey HJ, Veale AM, et al. Juvenile polyposis coli. Proc R Soc Med 1964;57:896-7.
6. Ruymann FB. Juvenile polyps with cachexia. Report of an infant and comparison with Cronkhite-Canada syndrome in adults. Gastroenterology 1969;57:431-8.
7. Alhan E, Unuvar E, Gumustekin E. Juvenile polyps of the colon and rectum. Turk J Pediatr 1988;30:99-103.
8. Desai DC, Neale KF, Talbot IC, et al. Juvenile polyposis. Br J Surg 1995;82:14-7.
9. Pillai RB, Tolia V. Colonic polyps in children: frequently multiple and recurrent. Clin Pediatr (Phila) 1998;37:253-7.
10. Reed K, Vose PC. Diffuse juvenile polyposis of the colon: a premalignant condition? Dis Colon Rectum 1981;24:205-10.
11. Hofting I, Pott G, Stolte M. The syndrome of juvenile polyposis. Leber Magen Darm 1993;23:107-8.
12. Howe JR, Sayed MG, Ahmed AF, et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet 2004; 41:484-91.
13. Sweet K, Willis J, Zhou XP, et al. Molecular classification of patients with unexplained hamartomatous and hyperplastic poly-posis. JAMA 2005;294:2465-73.
14. Howe JR, Haidle JL, Lal G, et al. ENG mutations in MADH4/ BMPR1A mutation negative patients with juvenile polyposis. Clin Genet 2007;71:91-2.
15. Van Hattem WA, Brosens LA, de Leng WW, et al. Large genomic deletions of SMAD4, BMPR1A, and PTEN in juvenile polyposis. Gut 2008;57:623-7.
16. Giardiello FM, Hamilton SR, Kern SE, et al. Colorectal neoplasia in juvenile polyposis or juvenile polyps. Arch Dis Child 1991; 66:971-5.
17. Jass JR, Williams CB, Bussey HJ, et al. Juvenile polyposis - a precancerous condition. Histopathology 1988; 13:619-30.
18. Shimizu T, Yamashiro Y, Unno A, et al. Mucosal microcirculation in juvenile polyps in children. J Pediatr Gastroenterol Nutr 1996;22:228-9.
19. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002;29 (6 Suppl 16):15-8.
20. Harper J, Moses MA. Molecular regulation of tumor angio-genesis: mechanisms and therapeutic implications. EXS 2006; 96:223-68.
21. Folkman J. Angiogenesis in cancer, vascular, rheumatoid, and other disease. Nat Med 1995;1:27-31.
22. Moses MA. The regulation of neovascularization of matrix metalloproteinases and their inhibitors. Stem Cells 1997; 15:180-9.
23. Moses MA, Sudhalter J, Langer R. Identification of an inhibitor of neovascularization from cartilage. Science 1990; 248:1408-10.
24. Lochter A, Sternlicht MD, Werb Z, et al. The significance of matrix metalloproteinases during early stages of tumor progression. Ann NY Acad Sci 1998;857:180-93.
25. Moses MA, Wiederschain D, Loughlin KR, et al. Increased incidence of matrix metalloproteinases in urine of cancer patients. Cancer Res 1998;58:1395-9.
26. Chan LW, Moses MA, Goley E, et al. Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy. J Clin Oncol 2004;22:499-506.
27. Fernandez CA, Yan L, Louis G, et al. The matrix metalloproteinase-9/ neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients. Clin Cancer Res 2005;11:5390-5.
28. Yan L, Borregaard N, Kjeldsen L, et al. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 2001;276:37258-65.
29. Bland M. An Introduction to Medical Statistics. 3rd ed. New York: Oxford University Press; 2000.
30. Thrailkill KM, Kumar S, Rosenberg CK, et al. Characterization of matrix metalloproteinases in human urine: alterations during adolescence. Pediatr Nephrol 1999;13:223-9.
31. Desai DC, Murday V, Phillips RK, et al. A survey of phenotypic features in juvenile polyposis. J Med Genet 1998;35:476-81.
32. Howe JR, Ringold JC, Hughes JH, et al. Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis. Surgery 1999;126:162-70.
33. Jacoby RF, Schlack S, Cole CE, et al. A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. Gastroenterology 1997; 112:1398-403.
34. Giardiello FM, Offerhaus JG. Phenotype and cancer risk of various polyposis syndromes. Eur J Cancer 1995;31A:1085-7.
35. Hoffenberg EJ, Sauaia A, Maltzman T, et al. Symptomatic colonic polyps in childhood: not so benign. J Pediatr Gastroenterol Nutr 1999;28:175-81.
36. Howe JR, Roth S, Ringold JC, et al. Mutations in the SMAD4/ DPC4 gene in juvenile polyposis. Science 1998;280:1086-8.
37. Howe JR, Bair JL, Sayed MG, et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 2001;28:184-7.