The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: Implications for galectin-glycan interactions at the cell surface

Biochemical Journal

Volumn 421, Issue 2, 2009, Pages 211-221

  Miller, Michelle C ^a   Nesmelova, Irina V ^a   Platt, David ^b   Klyosov, Anatole ^b   Mayo, Kevin H ^a  

^a University of Minnesota   (United States)

^b Pro Pharmaceuticals Inc   (United States)

Author keywords

Carbohydrate binding domain; Cell surface; Galectin glycan interactions; Heteronuclear single quantum coherence nuclear magnetic resonance (HSQC NMR); NMR diffusion spectroscopy; Simple saccharide

Indexed keywords

CELL SURFACE; GALECTIN-GLYCAN INTERACTIONS; HETERONUCLEAR SINGLE QUANTUM COHERENCE NUCLEAR MAGNETIC RESONANCE (HSQC NMR); NMR DIFFUSION SPECTROSCOPY; SIMPLE SACCHARIDE;

BINDING ENERGY; BINDING SITES; BIOCATALYSTS; CYTOLOGY; DIFFUSION; DISSOCIATION; EQUILIBRIUM CONSTANTS; MAGNETIC DOMAINS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS; POLYSACCHARIDES; RESONANCE; STOICHIOMETRY; SUGARS; SURFACE DIFFUSION;

CELL MEMBRANES;

CARBOHYDRATE BINDING PROTEIN; GALACTORHAMNOGALACTURONATE GLYCAN; GALECTIN 1; GLYCAN; GLYCOCONJUGATE; LACTOSE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOHYDRATE ANALYSIS; CARBOHYDRATE TRANSPORT; CELL MEMBRANE FLUIDITY; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION CONSTANT; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; LECTIN BINDING SITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PULSED FIELD GEL ELECTROPHORESIS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; GALECTIN 1; HUMANS; LACTOSE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYSACCHARIDES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 67650866515     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090265     Document Type: Article

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