Development of a bioresorbable self-hardening bone adhesive based on a composite consisting of polylactide methacrylates and β-tricalcium phosphate

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 90, Issue 1, 2009, Pages 55-66

  Heiss, C ^a   Kraus, R ^a   Peters, F ^b   Henn, W ^b   Schnabelrauch, M ^c   Berg, A ^c   Pautzsch, T ^c   Weisser, J ^c   Schnettler, R ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b Curasan AG   (Germany)

^c BIOMATERIALS DEPARTMENT   (Germany)

Author keywords

Adhesion; Bone regeneration; Calcium phosphate; Composite; Polylactic acid

Indexed keywords

ACIDS; ADHESION; BIODEGRADATION; BIOLOGICAL MATERIALS; BIOMATERIALS; BONE; CALCIUM; CALCIUM ALLOYS; DEGRADATION; HARDENING; MECHANICAL PROPERTIES; OLIGOMERS; PHOSPHATES;

ADHESION PROPERTIES; ALKALINE PHOSPHATASE ACTIVITY; BIORESORBABLE; BONE REGENERATION; COMPOSITE; END-GROUPS; HANDLING PROPERTIES; HUMID ATMOSPHERES; IN-VITRO; LACTIDE; MASS LOSS; MC3T3-E1 CELL; POLY LACTIDE; POLYLACTIC ACID; PROCESSING TIME; SHEAR RESISTANCES; SHELF LIFE; STORAGE TEMPERATURES; TRI-CALCIUM PHOSPHATES;

CALCIUM PHOSPHATE;

ALKALINE PHOSPHATASE; BIOMATERIAL; CALCIUM PHOSPHATE; METHACRYLIC ACID; OLIGOMER; POLY(METHYL METHACRYLATE); POLYLACTIDE;

ANIMAL CELL; ARTICLE; ATMOSPHERE; COMPOSITE MATERIAL; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; MOUSE; NONHUMAN; SCANNING ELECTRON MICROSCOPY; SHEAR STRENGTH; SHELF LIFE; TENSION; VISCOSITY;

3T3 CELLS; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE CEMENTS; CALCIUM PHOSPHATES; MATERIALS TESTING; METHACRYLATES; MICE; MICROSCOPY, ELECTRON, SCANNING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 67650786996     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31252     Document Type: Article

References (20)

1. Rietz KA. Polymer osteosynthesis. Experimental studies with an epoxy resin (Araldite AW 120). Acta Chir Scand 1964; 128:387-401.
2. Giebel G, Rimpler M. Skeletal system gluing: adhesives, 50 years of surgical aids (Part 1). Biomed Techn 1981;26:35-40. (Pubitemid 11107775)
3. Brandeis E, Katz D, Silberman M, Zinman C. A new bioadhesive for in vivo bone formation. J Mat Sci: Mater Med 1993;4:543-546. (Pubitemid 24018998)
4. Leeman RA, Hedinger C, Jenny M. Tierexperimentelle und histologische Ergebnisse bei der Frakturleimung mit dem Polyurethanpolymer 'Ostamer'. Schweiz Med Wschr 1961;91: 908-914.
5. Heiss C, Kraus R, Schluckebier D, Stiller AC, Wenisch S, Schnettler R. Bone adhesives in trauma and orthopedic surgery. Eur J Trauma 2006;32:141-148. (Pubitemid 44127475)
6. Linhart W, Peters F, Lehmann W, Schwarz K, Schilling AF, Amling M, Rueger JM, Epple M. Biologically and chemically optimized composites of carbonated apatite and polyglycolide as bone substitution materials. J Biomed Mater Res 2001;54: 162-171.
7. Ignatius A, Betz O, Augat P, Claes LE. In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes. J Biomed Mater Res B: Appl Biomater 2001;58:701-709.
8. Heiss C, Hahn N, Wenisch S, Alt V, Pokinskyj P, Horas U, Kilian O, Schnettler R. The tissue response to an alkylene bis(dilactoyl)-methacrylate bone adhesive. Biomaterials 2005; 26:1389-1396. (Pubitemid 39336515)
9. Heiss C, Hahn N, Pokinskyj P, Wenisch S, Stahl JP, Meyer C, Schnettler R. Properties and degradation of a new bioresorbable bone glue. Biomed Tech 2004;49:163-169. (Pubitemid 38886348)
10. Ignatius A, Augat P, Hollstein E, Schorlemmer S, Peraus M, Pokinskyj P, Claes L. Biocompatibility and functionality of the degradable polymer alkylene bis(dilactoyl)-methacrylate for screw-augmentation in vivo. J Biomed Mater Res B: Appl Biomater 2005;75:128-236. (Pubitemid 41395753)
11. Grossterlinden L, Janssen A, Schmitz N, Priemel M, Pogoda P, Amling M, Rueger JM, Linhart W. Deleterious tissue reaction to an alkylene bis(dilactoyl)-methacrylate bone adhesive in long-term follow up after screw augmentation in an ovine model. Biomaterials 2006;27:3379-3386.
12. Kühn KD. Bone Cements. Berlin: Springer; 2000.
13. Peters F, Reif D. Functional materials for bone regeneration from β-tricalcium phosphate. Mat-wiss u Werkstofftech 2004; 35:203-207. (Pubitemid 44616174)
14. International Center of Diffraction Data (ICDD). Powder Diffraction File PDF 2, Set 55, PDF #55-898 (2005), which replaced #9-169 (1959). Pennsylvania, USA: ICDD.
15. Itokazu M, Yang W, Aoki T, Ohara A, Kato N. Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing. Biomaterials 1997;19:817-819. (Pubitemid 28276632)
16. Cho SB, Nakanishi K, Kokubo T, Soga N, Ohtsuki C, Nakamura T, Kitsugi T, Yamamuro T. Dependence of apatite formation on silica gel on its structure: Effect of heat treatment. J Am Ceram Soc 1995;78:1769-1774.
17. Kim BS, Hrkach J, Langer R. Biodegradable photocrosslinked poly(ether-ester) networks for lubricious coatings. Biomaterials 2000;21:259-265.
18. Venkata MN, Thimma TR, Shekharam T. In situ polymerizable polyethyleneglycol containing polyesterpolyol acrylates for tissue sealant applications. Biomaterials 2004;25:3283-3291.
19. Winter A, Breit S, Porsch D, Benz K. Cartilage-like gene expression in differentiated human stem cell spheroides: A comparison of bone marrow-derived and adipose tissuederived stromal cells. Arthritis Rheum 2003;48:418-429. (Pubitemid 36278011)
20. Bradford MM. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein- dye binding. Anal Biochem 1976;72:248-254.