Electron beam-melted, free-form-fabricated titanium alloy implants: Material surface characterization and early bone response in rabbits

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 90 B, Issue 1, 2009, Pages 35-44

  Thomsen, Peter ^a   Malmström, Johan ^a   Emanuelsson, Lena ^a   René, Magnus ^b   Snis, Anders ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Arcam AB   (Sweden)

Author keywords

Bone; Electron beam melting; Free form fabrication; Histomorphometry; Osseointegration; Surface properties

Indexed keywords

ALUMINA; AUGER ELECTRON SPECTROSCOPY; BIOMECHANICS; BONE; ELECTRON BEAM FURNACES; ELECTRON BEAM MELTING; ELECTRON BEAMS; ELECTRONS; FABRICATION; MECHANICAL PROPERTIES; SURFACE ANALYSIS; SURFACE PROPERTIES; SURFACE ROUGHNESS; TITANIUM; TITANIUM ALLOYS; TRACE ANALYSIS; VANADIUM;

BONE RESPONSE; BULK CHEMICALS; CONTENT OF FE; DEPTH PROFILE; FREE-FORM-FABRICATION; FREEFORM; GEOMETRIC PROPERTIES; HISTOMORPHOMETRY; LIGHT MICROSCOPY; MATERIAL SURFACE; OSSEOINTEGRATION; REFERENCE MATERIAL; SHORT-TERM BEHAVIOR; STATISTICALLY SIGNIFICANT DIFFERENCE; SURFACE CHEMICAL COMPOSITION; SURFACE OXIDE; TI-6AL-4V; TISSUE RESPONSE; TITANIUM-6ALUMINUM-4VANADIUM;

SURFACES;

ALLOY; TITANIUM;

ANIMAL EXPERIMENT; ARTICLE; AUGER ELECTRON SPECTROSCOPY; BONE REGENERATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; ELECTRON BEAM; IMPLANT; INTERFEROMETRY; MICROSCOPY; MORPHOMETRICS; NONHUMAN; RABBIT; SURFACE PROPERTY; TISSUE REACTION; TOPOGRAPHY;

ANIMALS; BONE AND BONES; FEMALE; MICROSCOPY, ELECTRON, SCANNING; OSSEOINTEGRATION; PROSTHESES AND IMPLANTS; RABBITS; SURFACE PROPERTIES; TITANIUM;

EID: 67650786995     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31250     Document Type: Article

References (35)

1. Brånemark R, Brånemark P-I, Rydevik R, Myers RR. Osseointegration in skeletal reconstruction and rehabilitation: a review. J Rehabil Res Dev 2001;38:175-181.
2. Henry PJ. Clinical experiences with dental implants. Adv Dent Res 1999;13:147-152.
3. Hallman M, Mordenfeld A, Strandkvist T. A retrospective 5- year follow-up study of two different titanium implant surfaces used after interpositional bone grafting for reconstruction of the atrophic edentulous maxilla. Clin Implant Dent Relat Res 2005;7:121-126. (Pubitemid 41551720)
4. Laine P, Salo A, Kontio R, Ylijoki S, Lindqvist C, Suuronen R. Failed dental implants-Clinical, radiological and bacteriological findings in 17 patients. J Craniomaxillofac Surg 2005;33:212-217. (Pubitemid 40626705)
5. Thor A, Wannfors K, Sennerby L, Rasmusson L. Reconstruction of the severely resorbed maxilla with autogenous bone, platelet-rich plasma, and implants: 1-year results of a controlled prospective 5-year study. Clin Implant Dent Relat Res 2005;7:209-220. (Pubitemid 43129065)
6. Buser D, Martin W, Belser UC. Optimizing esthetics for implant restorations in the anterior maxilla: Anatomic and surgical considerations. Int J Oral Maxillofac Implants 2004;19 (Suppl):43-61. (Pubitemid 40115742)
7. Harvey BV. Optimizing the esthetic potential of implant restorations through the use of immediate implants with immediate provisionals. J Periodontol 2007;78:770-776.
8. Nag S, Banerjee R, Fraser HL. A novel combinatorial approach for understanding microstructural evolution and its relationship to mechanical properties in metallic biomaterials. Acta Biomater 2007;3:369-376. (Pubitemid 46555122)
9. Ostman PO, Hellman M, Sennerby L. Direct implant loading in the edentulous maxilla using a bone density-adapted surgical protocol and primary implant stability criteria for inclusion. Clin Implant Dent Relat Res 2005;7 (Suppl 1):S60-S69. (Pubitemid 40853688)
10. Touati B, Rompen E, Van Dooren E. A new concept for optimizing soft tissue integration. Pract Proced Aesthet Dent 2005;17:711-712, 714-715.
11. Malmstrom J, Adolfsson E, Arvidsson A, Thomsen P. Bone response inside free-form fabricated macroporous hydroxyapatite scaffolds with and without an open microporosity. Clin Implant Dent Relat Res 2007;9:79-88.
12. Malmström J, Adolfsson E, Emanuelsson L, Thomsen P. Bone ingrowth in zirconia and hydroxyapatite scaffolds with identical macroporosity. J Mater Sci Mater Med 2008;19: 2983-2992. (Pubitemid 351875741)
13. Lee SH, Shin H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliv Rev 2007;59:339-359. (Pubitemid 46879973)
14. Malmstrom J. On Bone Regeneration in Porous Bioceramics- Studies in Humans and Rabbits Using Free Form Fabricated Scaffolds. Göteborg: University of Göteborg, Sweden; 2007.
15. Larsson. Patent, SE 9301647, 1993.
16. Larsson C. The Interface Between Bone and Metals with Different Surface Properties-Light Microscopic and Ultrastructural Studies. Gothenburg: Göteborg University; 1997.
17. Larsson M, Lindhe U, Harrysson O. Rapid manufacturing with electron beam melting (EBM)-A manufacturing revolution? In: Bourell D, et al, editors. Proceedings Solid freeform fabrication symposium. Austin, TX; 2003. pp 433-438.
18. Donath K. Die Trenn-Dunnscliff-Technik zur Herstellung histologischer Präparaten von nicht schneidbaren Geweben und Materialen. Der Präparator 1988;34:318-325.
19. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage- Schliff (sawing and grinding) technique. J Oral Pathol 1982; 11:318-326. (Pubitemid 12092572)
20. Engqvist H, Botton GA, Couillard M, Mohammadi S, Malmstro ̈m J, Emanuelsson L, Hermansson L, Phaneuf MW, Thomsen P. A novel tool for high-resolution transmission electron microscopy of intact interfaces between bone and metallic implants. J Biomed Mater Res A 2006;78:20-24.
21. Brånemark R, Öhrnell L-O, Nilsson P, Thomsen P. Biomechanical characterization of osseointegration during healing: An experimental in vivo study in the rat. Biomaterials 1997:18:969-978. (Pubitemid 27296557)
22. Cooley DR, Van Dellen AF, Burgess JO, Windeler AS. The advantages of coated titanium implants prepared by radiofrequency sputtering from hydroxyapatite. J Prosthet Dent 1992; 67:93-100.
23. Hazan R, Brener R, Oron U. Bone growth to metal implants is regulated by their surface chemical properties. Biomaterials 1993;14:570-574. (Pubitemid 23219799)
24. Swart KM, Keller JC, Wightman JP, Draughn RA, Stanford CM, Michaels CM. Short-term plasma-cleaning treatments enhance in vitro osteoblast attachment to titanium. J Oral Implantol 1992;18:130-137.
25. Chehroudi B, Gould TR, Brunette DM. Effects of a grooved titanium-coated implant surface on epithelial cell behavior in vitro and in vivo. J Biomed Mater Res 1989;23:1067-1085. (Pubitemid 19211885)
26. Chehroudi B, Gould TR, Brunette DM. Titanium-coated micromachined grooves of different dimensions affect epithelial and connective-tissue cells differently in vivo. J Biomed Mater Res 1990;24:1203-1219. (Pubitemid 20269712)
27. Therin M, Meunier A, Christel P. A histomorphometric comparison of the muscular tissue reaction to stainless steel, pure titanium and titanium alloy implant materials. J Mater Sci Mater Med 1991;2:1-8.
28. Ricci JL, Spivak JM, Blumenthal N, Alexander H. Modulation of Bone Ingrowth by Surface Chemistry and Roughness. Toronto: Tononto University Press; 1991.
29. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res 1991;25:889-902.
30. Könönen M, Hormia M, Kivilahti J, Hautaniemi J, Thesleff I. Effect of surface processing on the attachment, orientation, and proliferation of human gingival fibroblasts on titanium. J Biomed Mater Res l992;26:1325-1341.
31. Lausmaa J. Surface spectroscopic characterization of titanium implant materials. J Electron Spectr Related Phenom 1996;81: 343-361. (Pubitemid 126370917)
32. Larsson C, Emanuelsson L, Thomsen P, Ericson LE, Aronsson BO, Kasemo B, Lausmaa J. Bone response to surface modified titanium implants-Studies on the tissue response after 1 year to machined and electropolished implants with different oxide thicknesses. J Mater Sci Mater Med 1997;8:721-729.
33. Boyan BD, Dean DD, Lohmann CH, Cochran DL, Sylvia VL, Schwartz Z. The titanium-bone cell interface in vitro: The role of the surface in promoting osteointegration. In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors. Titanium in Medicine. Berlin: Springer; 2001, Ch. 17, pp 562-585.
34. Rich A, Harris AK. Anomalous preferences of culture macrophages for hydrophobic and roughened substrata. J Cell Sci 1981:50:1-7. (Pubitemid 12225976)
35. Brunette DM. Principles of cell behavior on titanium surfaces and their applications to implanted devices. In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors. Titanium in Medicine. Berlin: Springer; 2001, Ch. 15, pp 486-512.