The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms

Journal of Endocrinology

Volumn 202, Issue 1, 2009, Pages 123-129

  Newson, Michael J F ^a   Roberts, Emma M ^a   Pope, George R ^a   Lolait, Stephen J ^a   O'Carroll, Anne Marie ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR[9-41]; PYROGLUTAMYLAPELIN 13; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN V1B RECEPTOR; APELIN 13 PEPTIDE; APELIN-13 PEPTIDE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING HORMONE (9 41); CORTICOTROPIN RELEASING HORMONE (9-41); HORMONE ANTAGONIST; HYDROCORTISONE; PEPTIDE FRAGMENT; SIGNAL PEPTIDE; VASOPRESSIN DERIVATIVE; VASOPRESSIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; VASOPRESSIN RELEASE; WILD TYPE; ANIMAL; BLOOD; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MOUSE MUTANT; NEUROSECRETION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CORTICOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROSECRETORY SYSTEMS; PEPTIDE FRAGMENTS; PITUITARY-ADRENAL SYSTEM; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, VASOPRESSIN; SIGNAL TRANSDUCTION; VASOPRESSINS;

EID: 67650756610     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0093     Document Type: Article

References (38)

1. Aguilera G 1994 Regulation of pituitary ACTH secretion during chronic stress. Frontiers in Neuroendocrinology 15 321-350.
2. Aguilera G & Rabadan-Diehl C 2000 Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation. Regulatory Peptides 96 23-29.
3. Bornstein SR & Chrousos GP 1999 Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs. Journal of Clinical Endocrinology and Metabolism 84 1729-1736.
4. Brailoiu GC, Dun S, Yang J, Ohsawa M, Chang JK & Dun NJ 2002 Apelin-immunoreactivity in the rat hypothalamus and pituitary. Neuroscience Letters 327 193-197.
5. Droste SK, Chandramohan Y, Hill LE, Linthorst ACE & Reul JMHM 2007 Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level. Neuroendocrinology 86 26-27.
6. Engelmann M, Landgraf R & Wotjak CT 2004 The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited. Frontiers in Neuroendocrinology 25 132-149.
7. Gillies GE, Linton EA & Lowry PJ 1982 Corticotropin-releasing activity of the new CRF is potentiated several times by vasopressin. Nature 299 355-357.
8. De Goeij DCE, Jezova D & Tilders FJ 1992 Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus. Brain Research 577 165-168.
9. Habata YH, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T et al. 1999 Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochimica et Biophysica Acta 1452 25-35.
10. Harbuz MS & Lightman SL 1992 Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation. Journal of Endocrinology 134 327-339.
11. Jaszberenyi M, Bujdoso E & Telegdy G 2004 Behavioral, neuroendocrine and thermoregulatory actions of apelin-13. Neuroscience 129 811-816.
12. Kagiyama S, Fukuhara M, Matsumura K, Lin Y, Fujii K & Iida M 2005 Central and peripheral cardiovascular actions of apelin in conscious rats. Regulatory Peptides 125 55-59.
13. Kjaer A, Knigge U, Bach FW & Warberg J 1992 Histamine- and stress-induced secretion of ACTH and beta-endorphin: involvement of corticotropin-releasing hormone and vasopressin. Neuroendocrinology 56 419-428.
14. Kleinz MJ & Davenport AP 2004 Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regulatory Peptides 118 119-125.
15. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR & O'Dowd BF 2000 Characterisation of apelin, the ligand for the APJ receptor. Journal of Neurochemistry 74 34-41.
16. Lolait SJ, Stewart LQ, Jessop DS, Young WSIII & O'Carroll A-M 2007a The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology 148 849-856.
17. Lolait SJ, Stewart LQ, Roper JA, Harrison G, Jessop DS, Young WSIII & O'Carroll A-M 2007b Attenuated stress response to acute lipopolysaccharide and ethanol administration in vasopressin V1b receptor knockout mice. Journal of Neuroendocrinology 19 543-551.
18. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE et al. 2003 Pharmacological and immunohistochemical characterisation of the APJ receptor and its endogenous ligand apelin. Journal of Neurochemistry 84 1162-1172.
19. El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D & Llorens-Cortes C 2004 Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. Journal of Neurochemistry 90 1290-1301.
20. De Mota N, Lenkei Z & Llorens-Cortes C 2000 Cloning, pharmacological characterisation and brain distribution of the rat apelin receptor. Neuroendocrinology 72 400-407.
21. De Mota N, Reaux-Le Goazigo A, El Messari S, Chartrel N, Roesch D, Dujardin C, Kordon C, Vaudry H, Moos F & Llorens-Cortes C 2004 Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. PNAS 101 10464-10469.
22. O'Carroll A-M & Lolait SJ 2003 Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraoptic nuclei by osmotic stimuli. Journal of Neuroendocrinology 15 661-666.
23. O'Carroll A-M, Selby TL, Palkovits M & Lolait SJ 2000 Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochimica et Biophysica Acta 1492 72-80.
24. O'Carroll A-M, Don AL & Lolait SJ 2003 APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. Journal of Neuroendocrinology 15 1095-1110.
25. O'Dowd BF, Heiber M, Chan A, Heng HHQ, Tsui L-C, Kennedy JL, Shi X, Petronis A, George SR & Nguyen T 1993 A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136 355-360.
26. Rabadan-Diehl C, Lolait SJ & Aguilera G 1995 Regulation of pituitary vasopressin V1b receptor mRNA during stress in the rat. Journal of Neuroendocrinology 7 903-910.
27. Reaux A, De Mota N, Skultetyova I, Lenkei Z, El Messari S, Gallatz K, Corvol P, Palkovits M & Llorens-Cortes C 2001 Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. Journal of Neurochemistry 77 1085-1096.
28. Reaux A, Gallatz K, Palkovits M & Llorens-Cortes C 2002 Distribution of apelin-synthesising neurons in the adult rat brain. Neuroscience 113 653-662.
29. Reaux-Le Goazigo A, Morinville A, Burlet A, Llorens-Cortes C & Beaudet A 2004 Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons. Endocrinology 145 4392-4400.
30. Reaux-Le Goazigo A, Alvear-Perez R, Zizzari P, Epelbaum J, Bluet-Pajot M-T & Llorens-Cortes C 2007 Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release. American Journal of Physiology. Endocrinology and Metabolism 292 E7-E15.
31. Stewart LQ, Roper JA, Young WSIII, O'Carroll A-M & Lolait SJ 2008 Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice. Journal of Neuroendocrinology 20 597-605.
32. Suda T, Nakano Y, Tozawa F, Sumitomo T, Sato Y, Yamada M & Demura H 1992 The role of corticotropin-releasing factor and vasopressin in hypoglycemia-induced proopiomelanocortin gene expression in the rat anterior pituitary gland. Brain Research 579 303-308.
33. Sunter D, Hewson AK & Dickson SL 2003 Intracerebroventricular injection of apelin-13 reduces food intake in the rat. Neuroscience Letters 353 1-4.
34. Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, Dakin C, Sajedi A, Ghatei M & Bloom S 2002 The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochemical and Biophysical Research Communications 291 1208-1212.
35. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C et al. 1998 Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251 471-476.
36. Tobin VA, Bull PM, Arunachalam S, O'Carroll A-M, Ueta Y & Ludwig M 2008 The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somatodendritic peptide release. Endocrinology 149 6136-6145.
37. Tramu G, Croix C & Pillez A 1983 Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Neuroendocrinology 37 467-469.
38. Ynag H, Wang L & Ju G 1977 Evidence for hypothalamic paraventricular nucleus as an integrative center of neuroimmunomodulation. Neuroimmunomodulation 4 120-127.