Determination of mitragynine in rat plasma by LC-MS/MS: Application to pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 24, 2009, Pages 2593-2597

  de Moraes, Natália Valadares ^a   Moretti, Raquel Alves Corrêa ^a   Furr III, Edward B ^b   McCurdy, Christopher R ^b   Lanchote, Vera Lucia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

LC MS MS; Mitragyna speciosa; Mitragynine; Pharmacokinetics; Rats

Indexed keywords

AMITRIPTYLINE; APPARENT VOLUME; INTERNAL STANDARDS; ISOAMYL ALCOHOL; LC-MS/MS; LINEAR RANGE; MITRAGYNA SPECIOSA; MITRAGYNINE; ORAL DOSE; PHARMACOKINETIC PARAMETERS; PLASMA CONCENTRATION; PLASMA SAMPLES; QUANTIFICATION LIMIT; RAT PLASMA; SAMPLING TIME;

DRUG PRODUCTS; HEXANE; PHARMACOKINETICS; PLASMA (HUMAN); RATS;

PLASMAS;

HEXANE; ISOPENTYL ALCOHOL; MITRAGYNINE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG ISOLATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; RATS; RATS, WISTAR; SECOLOGANIN TRYPTAMINE ALKALOIDS; TANDEM MASS SPECTROMETRY;

MITRAGYNA SPECIOSA; RATTUS;

EID: 67650753256     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.06.023     Document Type: Article

References (11)

1. Chittrakarn S., Sawangjaroen K., Prasettho S., Janchawee B., and Keawpradub N. J. Ethnopharmacol. 116 (2008) 173
2. Babu K.M., McCurdy C.R., and Boyer E.W. Clin. Toxicol. (Phila) 46 (2008) 146
3. Boyer E.W., Babu K.M., Adkins J.E., McCurdy C.R., and Halpern J.H. Addiction 103 (2008) 1048
4. Macko E., Weisbach J.A., and Douglas B. Arch. Int. Pharmacodyn. Ther. 198 (1972) 145
5. Watanabe K., Yano S., Syunji H., and Yamamoto L.T. Life Sci. 60 (1997) 933
6. Matsumoto K., Mizowaki M., Suchitra T., Takayama H., Sakai S.I., Aimi N., and Watanabe H. Life Sci. 59 (1996) 1149
7. Janchawee B., Keawpradub N., Chittrakarn S., Prasettho S., Wararatananurak P., and Sawangjareon K. Biomed. Chromatogr. 21 (2007) 176
8. Ponglux D., Wongseripipatana S., Takayama H., Kikuchi M., Kurihara M., Kitajima M., Aimi N., and Sakai S. Planta Med. 60 (1994) 580
9. Takayama H. Chem. Pharm. Bull. (Tokyo) 52 (2004) 916
10. Thongpradichote S., Matsumoto K., Tohda M., Takayama H., Aimi N., Sakai S., and Watanabe H. Life Sci. 62 (1998) 1371
11. Food and Drug Administration, Center for Drug Evaluation and Research (May, 2001), Available from: http://www.fda.gov/cder/guidance.