Hypoalbuminaemia and impaired renal function are associated with increased anticholinergic drug prescribing

International Journal of Clinical Practice

Volumn 63, Issue 7, 2009, Pages 1110-1114

  Parasca, A ^b   Doogue, M P ^b   Woodman, R J ^b   Mangoni, A A ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHOLINERGIC RECEPTOR BLOCKING AGENT; SERUM ALBUMIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; CONCENTRATION RESPONSE; CONFUSION; CONSTIPATION; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DRUG MEGADOSE; FALLING; FEMALE; GLOMERULUS FILTRATION RATE; HOSPITALIZATION; HUMAN; HYPOALBUMINEMIA; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LIVER FUNCTION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRESCRIPTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SIDE EFFECT; ACUTE KIDNEY FAILURE; CHEMICALLY INDUCED; REGRESSION ANALYSIS; RISK ASSESSMENT; VERY ELDERLY;

ACUTE KIDNEY INJURY; AGED; AGED, 80 AND OVER; CHOLINERGIC ANTAGONISTS; FEMALE; HUMANS; HYPOALBUMINEMIA; MALE; REGRESSION ANALYSIS; RISK ASSESSMENT;

EID: 67650739017     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2009.02067.x     Document Type: Article

References (33)

1. Jackson SH, Mangoni AA, Batty GM. Optimization of drug prescribing. Br J Clin Pharmacol 2004 57 : 231 6.
2. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004 57 : 6 14. (Pubitemid 38067945)
3. Wester K, Jonsson AK, Spigset O, Druid H, Hagg S. Incidence of fatal adverse drug reactions: a population based study. Br J Clin Pharmacol 2008 65 : 573 9.
4. Rivkin A. Admissions to a medical intensive care unit related to adverse drug reactions. Am J Health Syst Pharm 2007 64 : 1840 3.
5. Zhang M, Holman CD, Preen DB, Brameld K. Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980-2003. Br J Clin Pharmacol 2007 63 : 163 70.
6. Juntti-Patinen L, Neuvonen PJ. Drug-related deaths in a university central hospital. Eur J Clin Pharmacol 2002 58 : 479 82.
7. Laroche ML, Charmes JP, Nouaille Y, Picard N, Merle L. Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol 2007 63 : 177 86.
8. Passarelli MC, Jacob-Filho W, Figueras A. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging 2005 22 : 767 77.
9. Tune LE. Anticholinergic effects of medication in elderly patients. J Clin Psychiatry 2001 62 (Suppl. 21 11 4.
10. Moore AR, O'Keeffe ST. Drug-induced cognitive impairment in the elderly. Drugs Aging 1999 15 : 15 28. (Pubitemid 29358484)
11. Cao YJ, Mager DE, Simonsick EM et al. Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther 2008 83 : 422 9.
12. Mulsant BH, Pollock BG, Kirshner M, Shen C, Dodge H, Ganguli M. Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance. Arch Gen Psychiatry 2003 60 : 198 203. (Pubitemid 36173127)
13. Carnahan RM, Lund BC, Perry PJ, Pollock BG, Culp KR. The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 2006 46 : 1481 6.
14. Rudolph JL, Salow MJ, Angelini MC, McGlinchey RE. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med 2008 168 : 508 13.
15. Dhalla IA, Anderson GM, Mamdani MM, Bronskill SE, Sykora K, Rochon PA. Inappropriate prescribing before and after nursing home admission. J Am Geriatr Soc 2002 50 : 995 1000. (Pubitemid 34666303)
16. Bierman AS, Pugh MJ, Dhalla I et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother 2007 5 : 147 61.
17. Giron MS, Wang HX, Bernsten C, Thorslund M, Winblad B, Fastbom J. The appropriateness of drug use in an older nondemented and demented population. J Am Geriatr Soc 2001 49 : 277 83.
18. Gill SS, Misiaszek BC, Brymer C. Improving prescribing in the elderly: a study in the long term care setting. Can J Clin Pharmacol 2001 8 : 78 83. (Pubitemid 32776858)
19. Xiang YT, Weng YZ, Leung CM, Tang WK, Sandor UG. Exploring the clinical and social determinants of prescribing anticholinergic medication for Chinese patients with schizophrenia. Hum Psychopharmacol 2007 22 : 173 80.
20. Australian Medicines Handbook. 2008 edn. Adelaide : Australian Medicines Handbook Pty Ltd. 2008.
21. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999 130 : 461 70.
22. Iwata M, Kuzuya M, Kitagawa Y, Iguchi A. Prognostic value of serum albumin combined with serum C-reactive protein levels in older hospitalized patients: continuing importance of serum albumin. Aging Clin Exp Res 2006 18 : 307 11.
23. Wen CP, Cheng TY, Tsai MK et al. All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan. Lancet 2008 371 : 2173 82.
24. Hilmer SN, Mager DE, Simonsick EM et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med 2007 167 : 781 7.
25. Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997 315 : 1096 9.
26. Balant LP, Dayer P, Fabre J. Consequences of renal insufficiency on the hepatic clearance of some drugs. Int J Clin Pharmacol Res 1983 3 : 459 74.
27. Gibson TP. Renal disease and drug metabolism: an overview. Am J Kidney Dis 1986 8 : 7 17. (Pubitemid 16009430)
28. McLean AJ, Morgan DJ. Clinical pharmacokinetics in patients with liver disease. Clin Pharmacokinet 1991 21 : 42 69.
29. Slinin Y, Paudel ML, Ishani A et al. Kidney function and cognitive performance and decline in older men. J Am Geriatr Soc 2008 56 : 2082 8.
30. Flicker L, Ames D. Metabolic and endocrinological causes of dementia. Int Psychogeriatr 2005 17 (Suppl. 1 S79 92.
31. Brown TM, Brown RL. Neuropsychiatric consequences of renal failure. Psychosomatics 1995 36 : 244 53.
32. Ananth J, Swartz R, Burgoyne K, Gadasally R. Hepatic disease and psychiatric illness: relationships and treatment. Psychother Psychosom 1994 62 : 146 59.
33. Chew ML, Mulsant BH, Pollock BG et al. Anticholinergic activity of 107 medications commonly used by older adults. J Am Geriatr Soc 2008 56 : 1333 41.