A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation

Tetrahedron

Volumn 65, Issue 34, 2009, Pages 7105-7108

  Ivanov, Andrey S ^a   Zhalnina, Anna A ^a   Shishkov, Sergey V ^a  

^a R and D Department   (Russian Federation)

Author keywords

Bortezomib; Convergent synthesis; Peptide coupling; PS 341; Racemization; TBTU

Indexed keywords

ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; BORTEZOMIB; PROTEASOME INHIBITOR;

ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CHEMICAL REACTION; CONVERGENT SYNTHESIS; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; MANTLE CELL LYMPHOMA; MOLECULE; MULTIPLE MYELOMA; PRIORITY JOURNAL; RACEMIZATION;

EID: 67650688781     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.06.042     Document Type: Article

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