Is it safe to use recombinant human bone morphogenetic protein in posterior cervical fusion?

Spine

Volumn 34, Issue 9, 2009, Pages 885-889

  Hiremath, Girish K ^a   Steinmetz, Michael P ^a   Krishnaney, Ajit A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

BMP; Cervical fusion; Posterior; Safety

Indexed keywords

BONE MORPHOGENETIC PROTEIN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN; STEROID; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHI SQUARE TEST; CONGESTIVE HEART FAILURE; CONTROL GROUP; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG SAFETY; DYSPHAGIA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART ATRIUM FIBRILLATION; HUMAN; HYPONATREMIA; MAJOR CLINICAL STUDY; MALE; NECK PAIN; NECK SWELLING; NEUROLOGIC DISEASE; PANCREATITIS; POSTERIOR CERVICAL FUSION; PRIORITY JOURNAL; RADICULOPATHY; RESPIRATORY DISTRESS; RETROSPECTIVE STUDY; SEPSIS; SPINAL CORD DISEASE; SPINE FUSION; SWELLING; WEAKNESS; WOUND INFECTION;

ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEINS; CERVICAL VERTEBRAE; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PAIN, POSTOPERATIVE; POSTOPERATIVE COMPLICATIONS; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SPINAL FUSION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 67650682942     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31819e334a     Document Type: Article

References (22)

1. Urist MR. Bone: formation by autoinduction. Science 1965;150:893-9.
2. Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res Suppl 1971; 50:1392-1406.
3. Wang EA, Rosen V, Cordes P, et al. Purification and characterization of other distinct boneinducing factors. Proc Natl Acad Sci USA 1988;85: 9484-8.
4. Boden SD, Schimandle JH, Hutton WC. Lumbar intertransverse-process spinal arthrodesis using a bovine bone-derived osteoinductive protein. J Bone Joint Surg Am 1995;77:1404-17.
5. Boden SD, Schimandle JH, Hutton WC. 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion, part II: study of dose, carrier, and species. Spine 1995;20:2633-44.
6. Holliger EH, Trawick RH, Boden SD, et al. Morphology of the lumbar intertransverse process fusion mass in the rabbit model: a comparison between two bone graft materials - rhBMP-2 and autograft. J Spinal Disord 1996; 1996;9:125-8.
7. Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages: definitive evidence of osteoinduction in humans: a preliminary report. Spine 2000;25:376-81.
8. Boden SD, Kang J, Sandhu H, et al. Use of recombinant human bone mor-phogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans. A prospective, randomized clinical pilot trial. 2002 Volvo Award in clinical studies. Spine 2002;27:2662-73.
9. Burkus JK, Gornet MF, Dickman CA, et al. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 2002;15:337-49.
10. Burkus JK, Heim SE, Gornet MF, et al. Is INFUSE Bone Graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device. J Spinal Disord Tech 2003;16: 113-22.
11. Sandhu HS, Khan SN. Recombinant human bone morphogenetic protein-2:use in spinal fusion applications. J Bone Joint Surg Am 2003;85A: 89-95.
12. Sandhu HS. Bone morphogenetic proteins and spinal surgery. Spine 2003;1: 28(suppl 15):S64-73.
13. Baskin DS, Ryan P, Sonntag V, et al. A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic pro-tein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine 2003;28:1219-24.
14. Shields LB, Raque GH, Glassman SD, et al. Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 2006;1:31:542-7.
15. Smucker JD, Rhee JM, Singh K, et al. Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 2006;31:2813-9.
16. Vaidya R, Carp J, Sethi A, et al. Complications of anterior cervical discec-tomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J 2007;16:1257-65.
17. Vaidya R, Weir R, Sethi A, et al. Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg 2007;89-B:342-5.
18. Liu JK, Das K. Posterior fusion of the subaxial cervical spine: indications and techniques. Neurosurg Focus 2001;15:10:E7.
19. Benglis D, Wang MY, Levi AD. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery 2008; 62(ONS suppl 2): ONS423-31.
20. Boakye M, Mummaneni PV, Garrett M, et al. Anterior cervical discectomy and fusion involvinga polyetheretherketone spacer and bone morphogenetic protein. J Neurosurg Spine 2005;2:521-5.
21. Perri B, Cooper M, Lauryssen C, et al. Adverse swelling associated with use of rhBMP-2 in anterior cervical discectomy and fusion: a case study. Spine J 2007;7:235-9.
22. Govender S, Csimma C, Genant HK, et al. Recombinant human bone mor-phogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 2002;84-A:2123-34.