Small doses of methylene blue, previously considered safe, can precipitate serotonin toxicity

Anaesthesia

Volumn 64, Issue 8, 2009, Pages 924-

  Schwiebert, C ^a   Irving, C ^a   Gillman, P K ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

METHYLENE BLUE; MONOAMINE OXIDASE INHIBITOR; PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

AGITATION; ANESTHETIC RECOVERY; APHASIA; CASE REPORT; CENTRAL NERVOUS SYSTEM; CONFUSION; CYSTOSCOPY; DRUG SAFETY; HUMAN; HYPERREFLEXIA; HYPERTENSION; INTRAOPERATIVE PERIOD; LETTER; LOW DRUG DOSE; MYDRIASIS; NEUROTOXICITY; PELVIS CANCER; SEROTONIN SYNDROME; SIDE EFFECT;

COLORING AGENTS; DRUG INTERACTIONS; FEMALE; HUMANS; METHYLENE BLUE; POSTOPERATIVE COMPLICATIONS; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 67650672181     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/j.1365-2044.2009.06029.x     Document Type: Letter

References (5)

1. Gillman PK. Extracting value from case reports: lessons from serotonin toxicity. Anaesthesia 2006; 61: 419-422
2. Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. British Journal of Pharmacology 2007; 152: 946-951 (Pubitemid 350100489)
3. Medicines and Healthcare products Regulatory Agency. Methylthioninium chloride (methylene blue): CNS toxicity with serotonergic drugs. Drug Safety Update 2008; 1(6): 5.
4. Isbister GK, Buckley NA, Whyte IM. Serotonin toxicity: a practical approach to diagnosis and treatment. Medical Journal of Australia 2007; 187: 361-365
5. Boyer EW, Shannon M. The Serotonin Syndrome. New England Journal of Medicine 2005; 352: 1112-1120