Evaluation of wound healing activity of extracts of plantain banana (Musa sapientum var. paradisiaca) in rats

Indian Journal of Experimental Biology

Volumn 47, Issue 1, 2009, Pages 32-40

  Agarwal, P K ^a   Singh, A ^a   Gaurav, K ^a   Goel, Shalini ^a   Khanna, H D ^b   Goel, R K ^b  

^a Departments of Pharmacology   (India)

^b Department of Biophysics ^*  (India)

Author keywords

Antioxidant; Free radicals; Musa sapientum; Wound healing

Indexed keywords

MUSA X PARADISIACA; RATTUS;

ANTIOXIDANT; PLANT EXTRACT;

ANIMAL; ARTICLE; BANANA; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PHYTOTHERAPY; RAT; WOUND HEALING;

ANIMALS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MUSA; PHYTOTHERAPY; PLANT EXTRACTS; RATS; WOUND HEALING;

EID: 67650654922     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Evans P, The healing process at the cellular level. Physiotherapy, 20 (1983) 256.
2. Gupta N, Gupta S K, Shukla V K & Singh S P, An Indian community based epidemiological study of wounds, J Wound Care 13 (2004) 323.
3. Suguna L, Chandrakasan G & Joseph K T, Influence of honey on biochemical and biophysical parameters of wounds in rats. J Clinic Biochem Nutr, 14 (1999) 91.
4. Sharma S P, Aithal K S, Srinivasan K K, Udupa A L, Kumar V & Kulkarni D R, Anti-inflammatory and wound healing activities of the crude alcoholic extracts and flavanoids of Vitex leucoxylon. Fitoterapia, 61 (1990) 263.
5. Chithra P, Suguna L & Chandrakasan G, Influence of arginine wound healing in rats, J Clinic Biochem and Nutr, 18 (1995) 111.
6. Goel R K & Sairam K, Antiulcer drugs from indigenous sources with emphasis on Musa sapientum, Tamrabhasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol, 34 (2002) 100.
7. Goel R K, Chakrabarthy A & Sanyal A K, The effect of biological variables on the anti-ulcerogenic effect of vegetable plantain banana, Planta Med, 2 (1985) 85.
8. Bartolomucci E, Action of vitamin E on healing of experimental wounds on parenchymatous organs. JAMA, 113 (1939) 1079.
9. Musalmah M, Nizrana M Y, Fairuz A H, NoorAini A H, Azian A L, Gapor M T & Wan Ngah W Z, Comparative effects of palm vitamin E and alpha-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats. Lipid, 40(6) (2005) 575.
10. Morton J J & Malone M H, Evaluation of vulnerary activity by open wound procedure in rats, Arch Int Pharmacodyn Ther, 196 (1972) 117.
11. Lee K H, Studies on the mechanism of action of salicylates 3. Effect of vitamin A on wound healing retardation of aspirin, J Pharmacol Sci, 57 (1968) 1238.
12. Diwan P V, Tilloo L D & Kulkarni D R, Influence of Tridax procumbens on wound healing, Indian J Med Res, 75 (1982) 460.
13. Patil P A & Kulkarni D R, Effect of antiproliferative agents on healing of dead space wounds in rats, Indian J Med Res, 79 (1984) 445.
14. Newman R E & Logan M A, The determination of collagen and elastin in tissue, J Biochem, 186 (1972) 549.
15. Bitter T & Muir H, A modified uronic acid carbazole reaction, Anal Biochem, 204 (1953) 553.
16. Dische Z & Borenfreund E, A spectroscopic method for the microdetermination of hexosamine, J Biol Chem, 184 (1950) 517.
17. Kakkar P, Das B & Viswanathan P N, A modified spectrophotometric assay of superoxide dismutase, Indian J Biochem Biophy, 21 (1984) 130.
18. Sedlak J & Lindsay R H, Estimation of total protein bound and nonprotien sulfhydryl groups in tissue with Ellman's reagent, Anal Biochem, 25 (1968) 192.
19. Ohkawa H, Ohishi N & Yagi K, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal Biochem, 95 (1979) 351.
20. Clark R A F, Wound repair: overview and general consideration, in Molecular and cellular biology of wound repair, edited by RA Clark and PM Henson (The Plenum Press, New York) 1996.
21. Porras-Reyes B H, Lewis W H, Roman J, Simchowitz L & Mustoe T A, Enhancement of wound healing by the alkaloid taspine defining mechanism of action, Soc Exp Biol Med, 203 (1993) 18.
22. Biswas T K & Mukherjee B, Plant medicines of Indian origin for wound healing activity, Lower Extremity Wounds, 2 (2003) 25.
23. Goel R K & Sairam K, Antiulcer drugs from indigenous sources with emphasis on Musa sapientum, Tamrabhasma, Asparagus racemosus and Zingiber officinale, Indian J Pharmacol, 34 (2002) 100.
24. Graber A M, General surgery, wound management, (2002) [http://wound-science.com].
25. Udupa A L, Kulkarni D R & Udupa S L, Effect of Tridax procumbans extracts on wound healing, Int J Pharmacognosy, 33 (1995) 37.
26. Nohl H, Esterbauer H & Rice-Evans C, Free radicals in the environment in medicine and toxicology (Richelieu Press, London) 1994.
27. Senel O, Cetinkale O, Ozbay G, Ahcioglu F & Bulan R, Oxygen free radicals impair wound healing in ischaemic rat skin, Annals Plastic Surg, 39 (1997) 516.
28. Dissemond J, Goos M & Wagner S N, The role of oxidative stress in the pathogenesis and therapy of chronic wounds, Hautarzt 53 (2002) 718.
29. Halliwell B, Gutteridge J M & Grootveld M, Methods for the measurements of hydroxyl radicals in biomedical systems; deoxyribose degradation and aromatic hydroxylation, Methods Biochem Anal, 33 (1988) 59.
30. Gupta A, Singh R L & Raghubir R, Antioxidant status during cutaneous wound healing in immunocompromised rats, Mol Cell Biochem, 241 (2002) 1.
31. Rowan A, Mice, models and men: A critical evaluation of animal research, (State University of New York, Press Albany) 1984.
32. Lewis D A, Fields W N & Shaw G P, A natural flavanoid present in unripe banana plup (Musa sapientum L. var. paradisiacal) protects the gastric mucosa from aspirin-induced erosions, J Ethnopharmacol, 65 (1999) 283.
33. Ghosal S & Saini K S, Sitoindosides I and II, two new anti ulcerogenic sterylacyl glucosides from Musa paradisiacal, J Chem Res, 110 (1984) 965.
34. Ghosal S, Steryl glycosides and acylsteryl glycosides from Musa paradisiaca. Phyto Chem, 24 (1985) 1807.
35. Chattopadhyay S, Chaudhuri S & Ghosal S, Activation of peritoneal macrophages by sitoindoside-IV, an antiulcerogenic acylsterylglycoside from Musa paradisiacal, Planta Med, 53(1) (1987) 16.
36. Getie M, Gebre Mariam T, Reitz R & Neubert R H, Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae), Pharmazie, 57 (2002) 320.
37. Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, Tanaka T & Iinuma M, Comparative study on the antibacterial activity of phytochemical flavanones against methicillinresistant Staphylococcus aureus, J Ethnopharmacol, 50 (1996) 27.
38. Holzheimer R G & Steinmetz W G, Local and systemic concentrations of pro- and anti-inflammatory cytokines in human wounds, Eur J Med Res, 5 (2000) 347.
39. Robson M C, Cytokine manipulation of the wound, Clin Plast Surg, 30 (2003) 57.
40. Robson M C, Growth factors as wound healing agents, Curr Opin Biotech, 2 (1991) 863.