Scopoletin induces apoptosis of fibroblast-like synoviocytes from adjuvant arthritis rats by a mitochondrial-dependent pathway

Drug Development Research

Volumn 70, Issue 5, 2009, Pages 378-385

  Li, Ying ^a   Dai, Yue ^a,b   Liu, Mei ^a   Pan, Rong ^a   Luo, Yubin ^a   Xia, Yufeng ^a   Xia, Xiaofeng ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Fibroblast like synoviocytes; Rheumatoid arthritis; Scopoletin

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BETA ACTIN; CASPASE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; SCOPOLETIN;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTER TATARICUS; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ERYCIBE OBTUSIFOLIA; FIBROBLAST; FIBROBLAST LIKE SYNOVIOCYTE; FLOW CYTOMETRY; JOINT DESTRUCTION; MALE; MEDICINAL PLANT; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; STAINING; SYNOVIOCYTE;

EID: 67650651246     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20314     Document Type: Article

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