Developmental toxicity testing of monoclonal antibodies: An enhanced pre- and postnatal study design option

Reproductive Toxicology

Volumn 28, Issue 2, 2009, Pages 220-225

  Stewart, Jane ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Cynomolgus monkey; Developmental toxicity study designs; Monoclonal antibodies

Indexed keywords

GOLIMUMAB; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PANITUMUMAB;

ARTICLE; DRUG EXPOSURE; EMBRYO DEVELOPMENT; FETUS DEVELOPMENT; GESTATION PERIOD; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; MONKEY; NONHUMAN; ORGANOGENESIS; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL DEVELOPMENT; RISK ASSESSMENT; TERATOGENICITY;

ANIMAL USE ALTERNATIVES; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; MACACA FASCICULARIS; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTION; RESEARCH DESIGN; TOXICITY TESTS;

ANIMALIA; MACACA FASCICULARIS;

EID: 67650627735     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.04.002     Document Type: Article

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