Stability of triptorelin in the presence of dermis and epidermis

International Journal of Pharmaceutics

Volumn 378, Issue 1-2, 2009, Pages 149-151

  Bachhav, Yogeshwar G ^a   Kalia, Yogeshvar N ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Peptide; Skin; Stability; Transdermal; Triptorelin

Indexed keywords

PHOSPHATE BUFFERED SALINE; TRIPTORELIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRADATION KINETICS; DERMIS; DRUG DEGRADATION; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSFORMATION; EPIDERMIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKIN PENETRATION; SWINE;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DERMIS; DRUG STABILITY; EPIDERMIS; MODELS, BIOLOGICAL; SWINE; TIME FACTORS; TRIPTORELIN;

EID: 67650609836     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.053     Document Type: Article

References (10)

1. Helm V.J., and Muller B.W. Stability of gonadotropin and triptorelin in aqueous solution. Pharm. Res. 12 (1990) 1253-1256
2. Jacobi U., Kaiser M., Toll R., Mangelsdorf S., Audring H., Oftberg N., Sterry W., and Lademann J. Porcine ear skin: an in vitro model for human skin. Skin Res. Technol. 13 (2007) 19-24
3. Johnson D.M., Pritchard R.A., Taylor W.F., Conley D., Zuniga G., and McGreevy K.G. Degradation of the LH-RH analog nafarelin acetate in aqueous solution. Int. J. Pharm. 31 (1986) 125-129
4. Miller L.L., Kolaskie C.J., Smith G.A., and Rivier J. Transdermal iontophoresis of gonadotropin releasing hormone (LHRH) and two analogues. J. Pharm. Sci. 79 (1990) 490-493
5. Nicoli S., Rimondi S., Colombo P., and Santi P. Physical and chemical enhancement of transdermal delivery of triptorelin. Pharm. Res. 18 (2001) 1634-1637
6. Nicoli S., Santi P., Couvreur P., Couarraze G., Colombo P., and Fattal E. Design of triptorelin loaded nanospheres for transdermal iontophoretic administration. Int. J. Pharm. 214 (2001) 31-35
7. Schuetz Y.B., Naik A., Guy R.H., and Kalia Y.N. Emerging strategies for the transdermal delivery of peptide and protein drugs. Exp. Opin. Drug Deliv. 2 (2005) 533-548
8. Schuetz Y.B., Naik A., Guy R.H., Vuaridel E., and Kalia Y.N. Transdermal iontophoretic delivery of triptorelin. J. Pharm. Sci. 94 (2005) 2175-2182
9. Sekkat N., Kalia Y.N., and Guy R.H. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J. Pharm. Sci. 91 (2002) 2376-2381
10. In: Sweetman S. (Ed). Martindale: The Complete Drug Reference. 33rd ed. (2003), Pharmaceutical Press, London