Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: The Sefuri brain MRI study

Hypertension Research

Volumn 32, Issue 7, 2009, Pages 586-590

  Yao, Hiroshi ^a   Takashima, Yuki ^a   Mori, Takahiro ^a   Uchino, Akira ^b   Hashimoto, Manabu ^a   Yuzuriha, Takefumi ^a   Miwa, Yoshikazu ^c   Sasaguri, Toshiyuki ^c  

^a National Hospital Organization Hizen Psychiatric Center   (Japan)

^b SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN;

AGED; ALBUMIN BLOOD LEVEL; APATHY; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING;

AGED; BEHAVIOR; BLOOD PRESSURE; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR DISORDERS; COGNITION; COGNITION DISORDERS; FEMALE; HUMANS; HYPERTENSION; JAPAN; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS;

EID: 67650544972     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2009.65     Document Type: Article

References (28)

1. Yoshitake T, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, Ohmori S, Nomiyama K, Kawano H, Ueda K, Sueishi K, Tsuneyoshi M, Fujishima M. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study. Neurology 1995; 45: 1161-1168.
2. Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, Waldman A, Walton I, Poulter R, Ma S, Comsa M, Burch L, Fletcher A, Bulpitt C. HYVET investigators; HYVET investigators. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): A double-blind, placebo controlled trial. Lancet Neurol 2008; 7: 683-689.
3. Treiber KA, Lyketsos CG, Corcoran C, Steinberg M, Norton M, Green RC, Rabins P, Stein DM, Welsh-Bohmer KA, Breitner JC, Tschanz JT. Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. Int Psychogeriatr 2008; 20: 538-553.
4. Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG. Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J Neuropsychiatry Clin Neurosci 1992; 4 134-139.
5. Marin RS. Apathy: A neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991; 3: 243-254.
6. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study. JAMA 2002; 288: 1475-1483.
7. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. 'Vascular depression' hypothesis. Arch Gen Psychiatry 1997; 54: 915-922.
8. O'Brien JT, Firbank MJ, Krishnan MS, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, van Straaten EC, Inzitari D, LADIS Group. White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: The LADIS study. Am J Geriatr Psychiatry 2006; 14: 834-841.
9. Krishnan MS, O'Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, van Straaten EC, Inzitari D, LADIS Group. Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. Int J Geriatr Psychiatry 2006; 21: 983-989.
10. Williams JE, Nieto FJ, Sanford CP, Couper DJ, Tyroler HA. The association between trait anger and incident stroke risk: The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 2002; 33: 13-19.
11. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003; 348: 1215-1222.
12. Koga H, Takashima Y, Murakawa R, Uchino A, Yuzuriha T, Yao H. Cognitive consequences of multiple lacunes and leukoaraiosis as vascular cognitive impairment in community-dwelling elderly individuals. J Stroke Cerebrovasc Dis 2009; 18: 32-37.
13. Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, Marler JR, Leblanc GG. National Institute of Neurological Disorders and Stroke - Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 2006; 37: 2220-2241.
14. Ohmine T, Miwa Y, Yao H, Yuzuriha T, Takashima Y, Uchino A, Takahashi-Yanaga F, Morimoto S, Maehara Y, Sasaguri T. Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects. Hypertens Res 2008; 31: 75-81.
15. Takashima Y, Yao H, Koga H, Endo K, Matsumoto T, Uchino A, Sadanaga-Akiyoshi F, Yuzuriha T, Kuroda Y. Frontal lobe dysfunction caused by multiple lacunar infarction in community-dwelling elderly subjects. J Neurol Sci 2003; 214: 37-41.
16. Okada K, Kobayashi S, Aoki K, Suyama N, Yamaguchi S. Assessment of motivational loss in poststroke patients using the Japanese version of Starkstein's apathy scale. Jpn J Stroke 1998; 20: 318-327 (in Japanese.).
17. Sasaki M, Hirai T, Taoka T, Higano S, Wakabayashi C, Matsusue E, Ida M. Discriminating between silent cerebral infarction and deep white matter hyperintensity using combinations of three types of magnetic resonance images: A multicenter observer performance study. Neuroradiology 2008; 50: 753-758.
18. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993; 43: 1683-1689.
19. O'Sullivan M. Leukoaraiosis. Pract Neurol 2008; 8: 26-38.
20. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 2006; 16: 916-928.
21. Dufouil C, Chalmers J, Coskun O, Besançon V, Bousser MG, Guillon P, MacMahon S, Mazoyer B, Neal B, Woodward M, Tzourio-Mazoyer N, Tzourio C, PROGRESS MRI Substudy Investigators. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: The PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation 2005; 112: 1644-1650.
22. Wong TY, Klein R, Sharrett AR, Nieto FJ, Boland LL, Couper DJ, Mosley TH, Klein BE, Hubbard LD, Szklo M. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: The atherosclerosis risk in communities study. Stroke 2002; 33: 1487-1492.
23. Wardlaw JM, Sandercock PAG, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003; 34: 806-812.
24. Strandgaard S, Paulson OB. Cerebrovascular consequences of hypertension. Lancet 1994; 344: 519-521.
25. Yao H, Fujishima M. Cerebral blood flow and metabolism in silent brain infarction and related cerebrovascular disorders. Ann Med 2001; 33: 98-102.
26. Hama S, Kitaoka T, Shigenobu M, Watanabe A, Imura I, Seno H, Tominaga A, Arita K, Kurisu K. Malnutrition and nonthyroidal illness syndrome after stroke. Metabolism 2005; 54: 699-704.
27. Benton D, Donohoe RT. The effects of nutrients on mood. Public Health Nutr 1999; 2: 403-409.
28. Yao H, Yuzuriha T, Koga H, Fukuda K, Endo K, Matsumoto T, Kato A, Uchino A, Ezaki T, Ibayashi S, Uchimura H, Fujishima M. Decreased plasma tryptophan associated with deep white matter lesions in elderly subjects. J Neurol Neurosurg Psychiatry 1999; 66: 100-103.