Females have fewer complications and lower mortality following trauma than similarly injured males: A risk adjusted analysis of adults in the National Trauma Data Bank

Surgery

Volumn 146, Issue 2, 2009, Pages 308-315

  Haider, Adil H ^a   Crompton, Joseph G ^a   Oyetunji, Tolulope ^b   Stevens, Kent A ^a   Efron, David T ^a   Kieninger, Alicia N ^a   Chang, David C ^a   Cornwell III, Edward E ^b   Haut, Elliott R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; FEMALE; HOSPITAL ADMISSION; HUMAN; INJURY; INJURY SEVERITY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PNEUMONIA; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; SURVIVAL;

ABDOMINAL ABSCESS; ADULT; DATABASES, FACTUAL; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; KIDNEY FAILURE, ACUTE; MALE; PNEUMONIA; PULMONARY EMBOLISM; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SEX DISTRIBUTION; SURVIVAL RATE; UNITED STATES; WOUNDS AND INJURIES;

EID: 67650519406     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2009.05.006     Document Type: Article

References (25)

1. Sperry J.L., and Minei J.P. Gender dimorphism following injury: making the connection from bench to bedside. J Leukoc Biol 83 (2008) 499-506
2. Harbrecht B.G., Peitzman A.B., Rivera L., Heil B., Croce M., Morris J.A., et al. Contribution of age and gender to outcome of blunt splenic injury in adults: multicenter study of the eastern association for the surgery of trauma. J Trauma 51 (2001) 887-895
3. Wohltmann C.D., Franklin G.A., Boaz P.W., Luchette F.A., Kearney P.A., Richardson J.D., et al. A multicenter evaluation of whether gender dimorphism affects survival after trauma. Am J Surg 181 (2001) 297-300
4. Bowles B.J., Roth B., and Demetriades D. Sexual dimorphism in trauma? A retrospective evaluation of outcome. Injury 34 (2003) 27-31
5. Frink M., Pape H.C., van Griensven M., Krettek C., Chaudry I.H., and Hildebrand F. Influence of sex and age on mods and cytokines after multiple injuries. Shock 27 (2007) 151-156
6. Coimbra R., Hoyt D.B., Potenza B.M., Fortlage D., and Hollingsworth-Fridlund P. Does sexual dimorphism influence outcome of traumatic brain injury? The answer is no!. J Trauma 54 (2003) 689-700
7. Berkowitz D.M., and Martin G.S. Sepsis and sex: can we look beyond our hormones?. Chest 132 (2007) 1725-1727
8. Sperry J.L., Nathens A.B., Frankel H.L., Vanek S.L., Moore E.E., Maier R.V., et al. Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?. Crit Care Med 36 (2008) 1838-1845
9. Rappold J.F., Coimbra R., Hoyt D.V., Potenza B.M., Forlage D., Holbrook T., et al. Female gender does not protect blunt trauma patients from complications and mortality. J Trauma 53 (2002) 436-441
10. Committee on Trauma, American College of Surgeons. NTDB Version 7.0. Chicago, IL 2008.
11. Baker S.P., and O'Neill B. The injury severity score: an update. J Trauma 16 (1976) 882-885
12. Haider A.H., Chang D.C., Haute E.R., Cornwell III E.E., and Efron D.T. Mechanism of injury predicts patient mortality and impairment after blunt trauma. J Surg Res 153 (2009) 138-142
13. Haider A.H., Efron D.T., Haut E.R., et al. Black children experience worse clinical and functional outcomes after traumatic brain injury: an analysis of the National Pediatric Trauma Registry. J Trauma 62 (2007) 1259-1262 discussion 1262-3
14. Haider A.H., Chang D.C., Efron D.T., Haut E.R., Crandal M., and Corwell E.E. Race and insurance status as risk factors for trauma mortality. Arch Surg 143 (2008) 945-949
15. Wichmann M.W., Zellweger R., DeMaso C.M., Ayala A., and Chaudry I.H. Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock. Cytokine 8 (1996) 853-863
16. Diodato M., Knoferl M.W., Angele M.K., Schwacha M.G., Bland K.I., and Chaudry I.H. Gender differences in the inflammatory response and survival following hemorrhage and subsequent sepsis. Cytokine 14 (2001) 162-168
17. Angele M.K., Knoferl M.W., Ayala A., Cioffi W.G., Bland K., and Chaudry I.H. Male and female sex steroids: do they produce deleterious or beneficial effects on immune responses following trauma-hemorrhage?. Surg Forum 49 (1998) 43-45
18. Deitch E.A., Livingston D.H., Lavery R.F., et al. Hormonally active women tolerate shock-trauma better than do men: a prospective study of over 4000 trauma patients. Ann Surg 246 (2007) 447-453 discussion 453-5
19. Haider A.H., Efron D.T., Haut E.R., et al. Mortality in adolescent girls vs boys following traumatic shock: an analysis of the National Pediatric Trauma Registry. Arch Surg 142 (2007) 875-880 discussion 879-80
20. Magnotti L.J., Fischer P.E., Zarzaur B.L., Fabian T.C., and Croce M.A. Impact of gender on outcomes after blunt injury: a definitive analysis of more than 36,000 trauma patients. J Amer Coll Surg 206 (2008) 984-991 discussion 991-2
21. Offner P.J., Moore E.E., and Biffl W.L. Male gender is a risk factor for major infections after surgery. Arch Surg 134 (1999) 935-938
22. Oberholzer A., Keel M., Zellweger R., Steckholzer U., Trentz O., and Ertel W. Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma 48 (2000) 932-937
23. Croce M.A., Fabian T.C., Malhotra A.K., Bee T.K., and Miller P.R. Does gender difference influence outcome?. J Trauma 53 (2002) 889-894
24. Napolitano L.M., Greco M.E., Rodriguez A., Kufera J.A., West R.S., and Scalae T.M. Gender differences in adverse outcomes after blunt trauma. J Trauma 50 (2001) 274-280
25. Kardooni S., Haut E.R., Chang D.C., Pierce C.A., Efron D.T., Haider A.H., et al. Hazards of benchmarking complications with the National Trauma Data Bank: numerators in search of denominators. J Trauma 64 (2008) 273-277 discussion 277-9