Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats

Journal of Orthopaedic Research

Volumn 27, Issue 8, 2009, Pages 1088-1092

  Sekiya, Ichiro ^a   Tang, Tao ^a   Hayashi, Masaya ^a   Morito, Toshiyuki ^a   Ju, Young Jin ^a   Mochizuki, Tomoyuki ^a   Muneta, Takeshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Articular cartilage; BMP 7; Keratan sulfate; Strenuous running; Weekly injection

Indexed keywords

COLLAGEN TYPE 2; KERATAN SULFATE; OSTEOGENIC PROTEIN 1; RECOMBINANT OSTEOGENIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; KNEE OSTEOARTHRITIS; NONHUMAN; OVEREXERTION; PRIORITY JOURNAL; RAT; RUNNING;

ANIMALS; BONE MORPHOGENETIC PROTEIN 7; CARTILAGE, ARTICULAR; CHONDROCYTES; COLLAGEN TYPE II; INJECTIONS, INTRA-ARTICULAR; KERATAN SULFATE; KNEE JOINT; OSTEOARTHRITIS; RATS; RATS, WISTAR; RUNNING;

EID: 67650517757     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20840     Document Type: Article

References (21)

1. Wieland HA, Michaelis M, Kirschbaum BJ, et al. 2005. Osteoarthritis - an untreatable disease? Nat Rev Drug Discov 4:331-344.
2. Pap G, Eberhardt R, Sturmer I, et al. 1998. Development of osteoarthritis in the knee joints of Wistar rats after strenuous running exercise in a running wheel by intracranial self-stimulation. Pathol Res Pract 194:41-47.
3. Tang T, Muneta T, Ju YJ, et al. 2008. Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection. Arthritis Res Ther 10:R13.
4. Chubinskaya S, Hurtig M, Rueger DC. 2007. OP-1/BMP-7 in cartilage repair. Int Orthop 31:773-781.
5. Badlani N, Inoue A, Healey R, et al. 2008. The protective effect of OP-1 on articular cartilage in the development of osteoarthritis. Osteoarth Cart 16:600-606.
6. Hulmes DJ, Marsden ME, Strachan RK, et al. 2004. Intraarticular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content. Osteoarth Cart 12:232-238.
7. Mankin HJ, Dorfman H, Lippiello L, et al. 1971. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53:523-537.
8. Flechtenmacher J, Huch K, Thonar EJ, et al. 1996. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum 39:1896-1904.
9. Stove J, Schneider-Wald B, Scharf HP, et al. 2006. Bone morphogenetic protein 7 (bmp-7) stimulates proteoglycan synthesis in human osteoarthritic chondrocytes in vitro. Biomed Pharmacother 60:639-643.
10. Merrihew C, Soeder S, Rueger DC, et al. 2003. Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. J Bone Joint Surg Am 85-A:67-74.
11. Cook SD, Patron LP, Salkeld SL, et al. 2003. Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. J Bone Joint Surg Am 85-A:116-123.
12. Chubinskaya S, Merrihew C, Cs-Szabo G, et al. 2000. Human articular chondrocytes express osteogenic protein-1. J Histochem Cytochem 48:239-250.
13. Simic P, Culej JB, Orlic I, et al. 2006. Systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption. J Biol Chem 281:25509-25521.
14. Funderburgh JL. 2000. Keratan sulfate: structure, biosynthesis, and function. Glycobiology 10:951-958.
15. Tomatsu S, Okamura K, Maeda H, et al. 2005. Keratan sulphate levels in mucopolysaccharidoses and mucolipidoses. J Inherit Metab Dis 28:187-202.
16. Wakitani S, Nawata M, Kawaguchi A, et al. 2007. Serum keratan sulfate is a promising marker of early articular cartilage breakdown. Rheumatology (Oxford) 46:1652-1656.
17. Divine JG, Zazulak BT, Hewett TE. 2007. Viscosupplementation for knee osteoarthritis: a systematic review. Clin Orthop Relat Res 455:113-122.
18. D'Lima D, Hermida J, Hashimoto S, et al. 2006. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54:1814-1821.
19. Inoue A, Takahashi KA, Arai Y, et al. 2006. The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Arthritis Rheum 54:264-270.
20. Brandt KD, Mazzuca SA, Katz BP, et al. 2005. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015-2025.
21. Tiraloche G, Girard C, Chouinard L, et al. 2005. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum 52:1118-1128.