Biosynthesis of a linoleic acid allylic epoxide: Mechanistic comparison with its chemical synthesis and leukotriene a biosynthesis

Journal of Lipid Research

Volumn 50, Issue 7, 2009, Pages 1448-1455

  Niisuke, Katrin ^a   Boeglin, William E ^a   Murray, John J ^a,b   Schneider, Claus ^a,c   Brash, Alan R ^a,c  

^a Department of Pharmacology ^*  (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1H nuclear magnetic resonance; Anabaena; Biomimetic synthesis; Catalase; Cyanobacterium; Gas liquid chromatography mass spectrometry; Hemoprotein; Lipoxygenase; Peroxidase

Indexed keywords

11,12 EPOXYEICOSA 5,8,13,15 TETRAENOATE; 12,13 EPOXYOCTADECA 8,10 DIENOATE; 13 KETOOCTADECA 9,11 DIENOATE; 9,10 DIHYDROXY OCTADECA 11,13 DIENOIC ACID; 9,10 EPOXY 11 HYDROXY OCTADECA 12 ENOIC ACID; EPOXIDE; EPOXIDE HYDROLASE; LEUKOTRIENE A4 METHYL ESTER; LINOLEIC ACID; LINOLEIC ACID ALLYLIC EPOXIDE; UNCLASSIFIED DRUG;

ANABAENA; ARTICLE; AUTOOXIDATION; BIOSYNTHESIS; ENZYME MECHANISM; FATTY ACID METABOLISM; HYDROLYSIS; ISOLATION PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; STRUCTURE ANALYSIS;

ANABAENA; BACTERIAL PROTEINS; CATALASE; EPOXY COMPOUNDS; GLUTATHIONE; LEUKOTRIENE A4; LINOLEIC ACID; LIPOXYGENASE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECOMBINANT FUSION PROTEINS;

EID: 67650510961     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900025-JLR200     Document Type: Article

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