The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality

Critical Care Medicine

Volumn 37, Issue 4, 2009, Pages 1237-1243

  Read, Robert C ^a   Teare, Dawn M ^a   Pridmore, Alison C ^a   Naylor, Simone C ^a   Timms, James M ^a   Kaczmarski, Edward B ^b   Borrow, Raymond ^b   Wilson, Anthony G ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Death; Genetic susceptibility; Meningococcal disease; Neisseria meningitidis; Sepsis; Tumor necrosis factor

Indexed keywords

BIOCHEMICAL MARKER; MESSENGER RNA; NOTCH4 RECEPTOR; PROTEIN BAT3; PROTEIN CCHCR1; PROTEIN I KAPPA BL; PROTEIN LST1; PROTEIN LT ALPHA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; INFANT; LETHALITY; MACROPHAGE; MAJOR CLINICAL STUDY; MENINGOCOCCEMIA; NEISSERIA MENINGITIDIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; MALE; MENINGOCOCCAL INFECTIONS; MIDDLE AGED; POLYMORPHISM, GENETIC; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 67650508706     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819c39bc     Document Type: Article

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