Optic disc morphology - Rethinking shape

Progress in Retinal and Eye Research

Volumn 28, Issue 4, 2009, Pages 227-248

  Sanfilippo, Paul G ^a   Cardini, Andrea ^b,c   Hewitt, Alex W ^a   Crowston, Jonathan G ^a   Mackey, David A ^a,d  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF HULL   (United Kingdom)

^d UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Geometric morphometrics; Glaucoma; Measurement techniques; Optic disc morphology; Optic nerve; Shape analysis

Indexed keywords

ANALYTIC METHOD; BIOMETRY; COMPUTER GRAPHICS; EYE DISEASE; FOURIER ANALYSIS; GLAUCOMA; HERITABILITY; HUMAN; MORPHOMETRICS; OPTIC DISK; OPTIC DISK CUP; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; STATISTICS;

ANIMALS; BIOMETRY; COMPUTER GRAPHICS; DIAGNOSTIC IMAGING; GLAUCOMA; HUMANS; INHERITANCE PATTERNS; OPTIC DISK; OPTIC NERVE; OPTOMETRY;

EID: 67650504865     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2009.05.004     Document Type: Review

References (196)

1. Adams D.C., Rohlf F.J., and Slice D. Geometric morphometrics: ten years of progress following the 'revolution'. Ital. J. Zool. 71 (2004) 5-16
2. Adams, D.C., Cardini, A., Monteiro, L.R., O'Higgins, P., Rohlf, F.J. Morphometrics and phylogenetics: principal components of shape from cranial modules are neither appropriate nor effective cladistic characters. J. Hum. Evol., in press.
3. Alencar L.M., Bowd C., Weinreb R.N., Zangwill L.M., Sample P.A., and Medeiros F.A. Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1898-1906
4. Ansari-Shahrezaei S., Maar N., Biowski R., and Stur M. Biomicroscopic measurement of the optic disc with a high-power positive lens. Invest. Ophthalmol. Vis. Sci. 42 (2001) 153-157
5. Arvind H., George R., Raju P., Ve R.S., Mani B., Kannan P., and Vijaya L. Neural rim characteristics of healthy south Indians: the Chennai glaucoma study. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3457-3464
6. Atchley W.R., and Hall B.K. A model for development and evolution of complex morphological structures. Biol. Rev. Camb. Philos. Soc. 66 (1991) 101-157
7. Bastir M., O'Higgins P., and Rosas A. Facial ontogeny in Neanderthals and modern humans. Proc. Biol. Sci. 274 (2007) 1125-1132
8. Beck R.W., Savino P.J., Repka M.X., Schatz N.J., and Sergott R.C. Optic disk structure in anterior ischemic optic neuropathy. Ophthalmology 91 (1984) 1334-1337
9. Bellezza A.J., Hart R.T., and Burgoyne C.F. The optic nerve head as a biomechanical structure: initial finite element modeling. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2991-3000
10. Bellezza A.J., Rintalan C.J., Thompson H.W., Downs J.C., Hart R.T., and Burgoyne C.F. Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 44 (2003) 623-637
11. Bennett S.L., Hewitt A.W., Poulsen J.L., Kearns L.S., Morgan J.E., Craig J.E., and Mackey D.A. Screening for glaucomatous disc changes prior to diagnosis of glaucoma in myocilin pedigrees. Arch. Ophthalmol. 125 (2007) 112-116
12. Bookstein F.L. Principal warps: thin-plate splines and the decomposition of deformations. IEEE Trans. Pattern Anal. Mach. Intell. 11 (1989) 567-585
13. Bookstein F.L. Morphometric Tools for Landmark Data. Geometry and Biology (1991), Cambridge University Press, New York
14. Bookstein F.L. Landmark methods for forms without landmarks: morphometrics of group differences in outline shape. Med. Image Anal. 1 (1997) 225-243
15. Bookstein F.L., Sampson P.D., Streissguth A.P., and Connor P.D. Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain. Teratology 64 (2001) 4-32
16. Bookstein F.L., Streissguth A.P., Sampson P.D., Connor P.D., and Barr H.M. Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure. NeuroImage 15 (2002) 233-251
17. Bookstein F.L. Morphometrics. Encyclopedia of Life Sciences (2001), John Wiley and Sons, Ltd pp. 1-4
18. Bourne R.R., Foster P.J., Bunce C., Peto T., Hitchings R.A., Khaw P.T., Seah S.K., and Garway-Heath D.F. The morphology of the optic nerve head in the Singaporean Chinese population (the Tanjong Pagar study): part 1 - optic nerve head morphology. Br. J. Ophthalmol. 92 (2008) 303-309
19. Braga J., and Treil J. Estimation of pediatric skeletal age using geometric morphometrics and three-dimensional cranial size changes. Int. J. Legal Med. 121 (2007) 439-443
20. Britton R.J., Drance S.M., Schulzer M., Douglas G.R., and Mawson D.K. The area of the neuroretinal rim of the optic nerve in normal eyes. Am. J. Ophthalmol. 103 (1987) 497-504
21. Burgoyne C.F., Downs J.C., Bellezza A.J., and Hart R.T. Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissues. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4388-4399
22. Burgoyne C.F., Downs J.C., Bellezza A.J., Suh J.K., and Hart R.T. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog. Retin. Eye Res. 24 (2005) 39-73
23. Cardini A., Thorington R.W., and Polly P.D. Evolutionary acceleration in the most endangered mammal of Canada: speciation and divergence in the Vancouver Island marmot (Rodentia, Sciuridae). J. Evol. Biol. 20 (2007) 1833-1846
24. Cardini A., and Ohiggins P. Post-natal ontogeny of the mandible and ventral cranium in Marmota species (Rodentia, Sciuridae): allometry and phylogeny. Zoomorphology 124 (2005) 189-203
25. Cardini A., and Slice D. Mandibular shape in the genus Marmota: a preliminary analysis using outlines. Ital. J. Zool. 71 (2004) 17-25
26. Cardini A., and Thorington Jr. R.W. Postnatal ontogeny of marmot (Rodentia, Sciuridae) crania: allometric trajectories and species divergence. J. Mammal. 87 (2006) 201-215
27. Cardini A., and Tongiorgi P. Yellow-bellied marmots (Marmota flaviventris) 'in the shape space' (Rodentia, Sciuridae): sexual dimorphism, growth and allometry of the mandible. Zoomorphology 122 (2003) 11-23
28. Chauhan B.C., McCormick T.A., Nicolela M.T., and LeBlanc R.P. Optic disc and visual field changes in a prospective longitudinal study of patients with glaucoma: comparison of scanning laser tomography with conventional perimetry and optic disc photography. Arch. Ophthalmol. 119 (2001) 1492-1499
29. Cheverud J.M. Developmental integration and the evolution of pleiotropy. Am. Zool. 36 (1996) 44-50
30. Chihara E., and Chihara K. Covariation of optic disc measurements and ocular parameters in the healthy eye. Graefes Arch. Clin. Exp. Ophthalmol. 232 (1994) 265-271
31. Cole T.M., Lele S., and Richtsmeier J.T. A parametric bootstrap approach to the detection of phylogenetic signals in landmark data. In: MacLeod N., and Forey P. (Eds). Morphometrics, Shape, and Phylogenetics (2002), Taylor and Francis, London 194-219
32. Coops A., Henson D.B., Kwartz A.J., and Artes P.H. Automated analysis of heidelberg retina tomograph optic disc images by glaucoma probability score. Invest. Ophthalmol. Vis. Sci. 47 (2006) 5348-5355
33. Corti M. Geometric morphometrics: an extension of the revolution. Trends Ecol. Evol. 8 (1993) 302-303
34. Crowston J.G., Hopley C.R., Healey P.R., Lee A., Mitchell P., and Study B.M.E. The effect of optic disc diameter on vertical cup to disc ratio percentiles in a population based cohort: the Blue Mountains Eye Study. Br. J. Ophthalmol. 88 (2004) 766-770
35. Daegling D.J., and Jungers W.L. Elliptical Fourier analysis of symphyseal shape in great ape mandibles. J. Hum. Evol. 39 (2000) 107-122
36. De León-Ortega J.E., Sakata L.M., Monheit B.E., McGwin G., Arthur S.N., and Girkin C.A. Comparison of diagnostic accuracy of Heidelberg Retina Tomograph II and Heidelberg Retina Tomograph 3 to discriminate glaucomatous and nonglaucomatous eyes. Am. J. Ophthalmol. 144 (2007) 525-532
37. DeQuardo J.R., Bookstein F.L., Green W.D., Brunberg J.A., and Tandon R. Spatial relationships of neuroanatomic landmarks in schizophrenia. Psychiatry Res. 67 (1996) 81-95
38. Derado G., Mardia K., Patrangenaru V., and Thompson H. A shape-based glaucoma index for tomographic images. J. Appl. Stat. 31 (2004) 1241-1248
39. Downs J.C., Yang H., Girkin C., Sakata L., Bellezza A., Thompson H., and Burgoyne C.F. Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: neural canal and subarachnoid space architecture. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3195-3208
40. Dryden I.L., and Mardia K.V. Multivariate shape analysis. Sankhya 55 (1993) 460-480
41. Dryden I.L., and Mardia K.V. Statistical Shape Analysis (1998), John Wiley and Sons, New York
42. Durukan A.H., Yucel I., Akar Y., and Bayraktar M.Z. Assessment of optic nerve head topographic parameters with a confocal scanning laser ophthalmoscope. Clin. Exp. Ophthalmol. 32 (2004) 259-264
43. Ervin J.C., Lemij H.G., Mills R.P., Quigley H.A., Thompson H.W., and Burgoyne C.F. Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomography in the LSU Experimental Glaucoma (LEG) Study. Ophthalmology 109 (2002) 467-481
44. Essock E.A., Sinai M.J., Fechtner R.D., Srinivasan N., and Bryant F.D. Fourier analysis of nerve fiber layer measurements from scanning laser polarimetry in glaucoma: emphasizing shape characteristics of the 'double-hump' pattern. J. Glaucoma 9 (2000) 444-452
45. Essock E.A., Sinai M.J., Bowd C., Zangwill L.M., and Weinreb R.N. Fourier analysis of optical coherence tomography and scanning laser polarimetry retinal nerve fiber layer measurements in the diagnosis of glaucoma. Arch. Ophthalmol. 121 (2003) 1238-1245
46. Essock E.A., Gunvant P., Zheng Y., Garway-Heath D.F., Kotecha A., and Spratt A. Predicting visual field loss in ocular hypertensive patients using Wavelet-Fourier analysis of GDx scanning laser polarimetry. Optom. Vis. Sci. 84 (2007) 380-387
47. Falconer D.S., and Mackay T.F.C. Introduction to Quantitative Genetics (1996), Longman Group, Harlow, UK
48. Ferreras A., Pajarín A.B., Polo V., Larrosa J.M., Pablo L.E., and Honrubia F.M. Diagnostic ability of Heidelberg Retina Tomograph 3 classifications: glaucoma probability score versus Moorfields regression analysis. Ophthalmology 114 (2007) 1981-1987
49. Ferreras A., Pablo L.E., Pajarín A.B., Larrosa J.M., Polo V., and Pueyo V. Diagnostic ability of the heidelberg retina tomograph 3 for glaucoma. Am. J. Ophthalmol 145 (2008) 354-359
50. Ferreras A., Pablo L.E., Larrosa J.M., Polo V., Pajarín A.B., and Honrubia F.M. Discriminating between normal and glaucoma-damaged eyes with the Heidelberg Retina Tomograph 3. Ophthalmology 115 (2008) 775-781
51. Franklin D., and Cardini A. Mandibular morphology as an indicator of human subadult age: interlandmark approaches. J. Forensic Sci. 52 (2007) 1015-1019
52. Franklin D., O'Higgins P., Oxnard C.E., and Dadour I. Determination of sex in South African Blacks by discriminant function analysis of mandibular linear dimensions: a preliminary investigation using the Zulu local population. Forensic Sci. Med. Pathol. 2 (2006) 263-268
53. Franklin D., O'Higgins P., Oxnard C.E., and Dadour I. Sexual dimorphism and population variation in the adult mandible: forensic applications of geometric morphometrics. Forensic Sci. Med. Pathol. 3 (2007) 15-22
54. Franklin D., Oxnard C.E., O'Higgins P., and Dadour I. Sexual dimorphism in the subadult mandible: quantification using geometric morphometrics. J. Forensic Sci. 52 (2007) 6-10
55. Franklin D., Cardini A., O'Higgins P., Oxnard C.E., and Dadour I. Mandibular morphology as an indicator of human subadult age: geometric morphometric approaches. Forensic Sci. Med. Pathol. 4 (2008) 91-99
56. Gabriele M.L., Wollstein G., Bilonick R.A., Burgansky-Eliash Z., Ishikawa H., Kagemann L.E., and Schuman J.S. Comparison of parameters from Heidelberg Retina Tomographs 2 and 3. Ophthalmology 115 (2008) 673-677
57. Garway-Heath D.F., Wollstein G., and Hitchings R.A. Aging changes of the optic nerve head in relation to open angle glaucoma. Br. J. Ophthalmol. 81 (1997) 840-845
58. Garway-Heath D.F., and Hitchings R.A. Quantitative evaluation of the optic nerve head in early glaucoma. Br. J. Ophthalmol. 82 (1998) 352-361
59. Gharaibeh W.S., Rohlf F.J., Slice D.E., and DeLisi L.E. A geometric morphometric assessment of change in midline brain structural shape following a first episode of schizophrenia. Biol. Psychiatry 48 (2000) 398-405
60. Gloster J. Vertical ovalness of glaucomatous cupping. Br. J. Ophthalmol. 59 (1975) 721-724
61. González-José R., Escapa I., Neves W.A., Cúneo R., and Pucciarelli H.M. Cladistic analysis of continuous modularized traits provides phylogenetic signals in Homo evolution. Nature 453 (2008) 775-778
62. Greaney M.J., Hoffman D.C., Garway-Heath D.F., Nakla M., Coleman A.L., and Caprioli J. Comparison of optic nerve imaging methods to distinguish normal eyes from those with glaucoma. Invest. Ophthalmol. Vis. Sci. 43 (2002) 140-145
63. Green W.D.K. The thin-plate spline and images with curving features. In: Mardia K.V., Gill C.A., and Dryden I.L. (Eds). Image Fusion and Shape Variability (1996), University of Leeds Press, Leeds 79-87
64. Green C.M., Kearns L.S., Wu J., Barbour J.M., Wilkinson R.M., Ring M.A., Craig J.E., Wong T.L., Hewitt A.W., and Mackey D.A. How significant is a family history of glaucoma? Experience from the Glaucoma Inheritance Study in Tasmania. Clin. Exp. Ophthalmol. 35 (2007) 793-799
65. Gunvant P., Zheng Y., Essock E.A., Parikh R.S., Prabakaran S., Babu J.G., Shekar G.C., and Thomas R. Application of shape-based analysis methods to OCT retinal nerve fiber layer data in glaucoma. J. Glaucoma 16 (2007) 543-548
66. Guy F., Mackaye H., Likius A., Vignaud P., Schmittbuhl M., and Brunet M. Symphyseal shape variation in extant and fossil hominoids, and the symphysis of Australopithecus bahrelghazali. J. Hum. Evol. 55 (2008) 37-47
67. Hall B.K. Evo-devo: evolutionary developmental mechanisms. Int. J. Dev. Biol. 47 (2003) 491-495
68. Hallgrímsson B., Willmore K., Dorval C., and Cooper D.M.L. Craniofacial variability and modularity in macaques and mice. J. Exp. Zool. Part B Mol. Dev. Evol. 302 (2004) 207-225
69. Hallgrímsson B., Brown J.J.Y., Ford-Hutchinson A.F., Sheets H.D., Zelditch M.L., and Jirik F.R. The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration. Evol. Dev. 8 (2006) 61-73
70. Hallgrimsson, B., Lieberman, D.E., Young, N.M., Parsons, T., 2007. Evolution of covariance in the mammalian skull. Novartis Foundation Symposium.
71. Harizman N., Zelefsky J.R., Ilitchev E., Tello C., Ritch R., and Liebmann J.M. Detection of glaucoma using operator-dependent versus operator-independent classification in the Heidelberg retinal tomograph-III. Br. J. Ophthalmol. 90 (2006) 1390-1392
72. Harizman N., Oliveira C., Chiang A., Tello C., Marmor M., Ritch R., and Liebmann J.M. The ISNT rule and differentiation of normal from glaucomatous eyes. Arch. Ophthalmol. 124 (2006) 1579-1583
73. Harju M., and Vesti E. Scanning laser ophthalmoscopy of the optic nerve head in exfoliation glaucoma and ocular hypertension with exfoliation syndrome. Br. J. Ophthalmol. 85 (2001) 297-303
74. Harvati K., Frost S.R., and McNulty K.P. Neanderthal taxonomy reconsidered: implications of 3D primate models of intra- and interspecific differences. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 1147-1152
75. Haslett R.S., Batterbury M., Cuypers M., and Cooper R.L. Inter-observer agreement in clinical optic disc measurement using a modified 60 D lens. Eye 11 (1997) 692-697
76. Hatch W.V., Flanagan J.G., Etchells E.E., Williams-Lyn D.E., and Trope G.E. Laser scanning tomography of the optic nerve head in ocular hypertension and glaucoma. Br. J. Ophthalmol. 81 (1997) 871-876
77. Healey P.R., and Mitchell P. Optic disk size in open-angle glaucoma: the Blue Mountains Eye Study. Am. J. Ophthalmol. 128 (1999) 515-517
78. Healy-Williams N., and Williams D.F. Fourier analysis of test shape of planktonic foraminifera. Nature 289 (1981) 485-487
79. Hennessy R.J., Kinsella A., and Waddington J.L. 3D laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism. Biol. Psychiatry 51 (2002) 507-514
80. Hennessy R.J., Lane A., Kinsella A., Larkin C., O'Callaghan E., and Waddington J.L. 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia. Schizophr. Res. 67 (2004) 261-268
81. Hennessy R.J., McLearie S., Kinsella A., and Waddington J.L. Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerebral-craniofacial morphogenesis and cognitive function. J. Anat. 207 (2005) 283-295
82. Hewitt A.W., Traill A., Cooper R.L., Morgan J.E., and Mackey D.A. Tools for cup:disc ratio measurement. Clin. Exp. Ophthalmol. 34 (2006) 288-289
83. Hewitt A.W., Poulsen J.L., Alward W.L., Bennett S.L., Budde W.M., Cooper R.L., Craig J.E., Fingert J.H., Foster P.J., Garway-Heath D.F., Green C.M., Hammond C.J., Hayreh S.S., Jonas J.B., Kaufman P.L., Miller N.R., Morgan W.H., Newman N.J., Quigley H.A., Samples J.R., Spaeth G.L., Pesudovs K., and Mackey D.A. Heritable features of the optic disc: a novel twin method for determining genetic significance. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2469-2475
84. Hoffmann E.M., Bowd C., Medeiros F.A., Boden C., Grus F.H., Bourne R.R., Zangwill L.M., and Weinreb R.N. Agreement among 3 optical imaging methods for the assessment of optic disc topography. Ophthalmology 112 (2005) 2149-2156
85. Hoffmann E.M., Zangwill L.M., Crowston J.G., and Weinreb R.N. Optic disk size and glaucoma. Surv. Ophthalmol. 52 (2007) 32-49
86. Iester M., Mikelberg F.S., Swindale N.V., and Drance S.M. ROC analysis of Heidelberg Retina Tomograph optic disc shape measures in glaucoma. Can. J. Ophthalmol. 32 (1997) 382-388
87. Iester M., Rolando M., and Macrì A. Three-dimensional optic nerve head algorithm for the detection of glaucomatous damage. Graefes Arch. Clin. Exp. Ophthalmol. 239 (2001) 469-473
88. Jonas J.B., and Budde W.M. Is the nasal optic disc sector important for morphometric glaucoma diagnosis?. Br. J. Ophthalmol. 86 (2002) 1232-1235
89. Jonas J.B., Gusek G.C., Guggenmoos-Holzmann I., and Naumann G.O. Optic nerve head drusen associated with abnormally small optic discs. Int. Ophthalmol. 11 (1987) 79-82
90. Jonas J.B., Gusek G.C., Guggenmoos-Holzmann I., and Naumann G.O. Size of the optic nerve scleral canal and comparison with intravital determination of optic disc dimensions. Graefes Arch. Clin. Exp. Ophthalmol. 226 (1988) 213-215
91. Jonas J.B., Gusek G.C., Guggenmoos-Holzmann I., and Naumann G.O. Variability of the real dimensions of normal human optic discs. Graefes Arch. Clin. Exp. Ophthalmol. 226 (1988) 332-336
92. Jonas J.B., Gusek G.C., and Naumann G.O. Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intrapapillary characteristics. Graefes Arch. Clin. Exp. Ophthalmol. 226 (1988) 522-530
93. Jonas J.B., Gusek G.C., and Naumann G.O. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest. Ophthalmol. Vis. Sci. 29 (1988) 1151-1158
94. Jonas J.B., Fernandez M.C., and Naumann G.O. Glaucomatous optic nerve atrophy in small discs with low cup-to-disc ratios. Ophthalmology 97 (1990) 1211-1215
95. Jonas J.B., Müller-Bergh J.A., Schlötzer-Schrehardt U.M., and Naumann G.O. Histomorphometry of the human optic nerve. Invest. Ophthalmol. Vis. Sci. 31 (1990) 736-744
96. Jonas J.B., Fernández M.C., and Naumann G.O. Correlation of the optic disc size to glaucoma susceptibility. Ophthalmology 98 (1991) 675-680
97. Jonas J.B., Fernández M.C., and Stürmer J. Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 100 (1993) 63-68
98. Jonas J.B., Kling F., and Gründler A.E. Optic disc shape, corneal astigmatism, and amblyopia. Ophthalmology 104 (1997) 1934-1937
99. Jonas J.B., Mardin C.Y., and Gründler A.E. Comparison of measurements of neuroretinal rim area between confocal laser scanning tomography and planimetry of photographs. Br. J. Ophthalmol. 82 (1998) 362-366
100. Jonas J.B., Budde W.M., and Lang P. Neuroretinal rim width ratios in morphological glaucoma diagnosis. Br. J. Ophthalmol. 82 (1998) 1366-1371
101. Jonas J.B., Budde W.M., and Panda-Jonas S. Ophthalmoscopic evaluation of the optic nerve head. Surv. Ophthalmol. 43 (1999) 293-320
102. Jonas J.B., Bergua A., Schmitz-Valckenberg P., Papastathopoulos K.I., and Budde W.M. Ranking of optic disc variables for detection of glaucomatous optic nerve damage. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1764-1773
103. Jonas J.B., Thomas R., George R., Berenshtein E., and Muliyil J. Optic disc morphology in south India: the Vellore Eye Study. Br. J. Ophthalmol. 87 (2003) 189-196
104. Jonas J.B., Xu L., Zhang L., Wang Y., and Wang Y. Optic disk size in chronic glaucoma: the Beijing eye study. Am. J. Ophthalmol. 142 (2006) 168-170
105. Jonas J.B., and Fernandez M.C. Shape of the neuroretinal rim and position of the central retinal vessels in glaucoma. Br. J. Ophthalmol. 78 (1994) 99-102
106. Jonas J.B., and Königsreuther K.A. Optic disk appearance in ocular hypertensive eyes. Am. J. Ophthalmol. 117 (1994) 732-740
107. Jonas J.B., and Papastathopoulos K. Ophthalmoscopic measurement of the optic disc. Ophthalmology 102 (1995) 1102-1106
108. Jonas J.B., and Papastathopoulos K.I. Optic disc shape in glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 234 Suppl. 1 (1996) S167-S173
109. Jungers W.L., Falsetti A.B., and Wall C.E. Shape, relative size, and size-adjustments in morphometrics. Yearb. Phys. Anthropol. 38 (1995) 137-161
110. Kendall D.G. A survey of the statistical theory of shape. Stat. Sci. 4 (1989) 87-99
111. Kieser J.A., Bernal V., Neil Waddell J., and Raju S. The uniqueness of the human anterior dentition: a geometric morphometric analysis. J. Forensic Sci. 52 (2007) 671-677
112. Kiriyama N., Ando A., Fukui C., Nambu H., Nishikawa M., Terauchi H., Kuwahara A., and Matsumura M. A comparison of optic disc topographic parameters in patients with primary open angle glaucoma, normal tension glaucoma, and ocular hypertension. Graefes Arch. Clin. Exp. Ophthalmol. 241 (2003) 541-545
113. Klingenberg C.P. Morphometrics and the role of the phenotype in studies of the evolution of developmental mechanisms. Gene 287 (2002) 3-10
114. Klingenberg C.P. Integration, modules and development: molecules to morphology to evolution. In: Pigliucci M., and Preston K. (Eds). Phenotypic Integration: Studying the Ecology and Evolution of Complex Phenotypes (2004), Oxford University Press, New York 213-230
115. Klingenberg C.P. MorphoJ. Faculty of Life Sciences (2008), University of Manchester, UK. http://www.flywings.org.uk/MorphoJ_page.htm
116. Klingenberg C.P., Leamy L.J., Routman E.J., and Cheverud J.M. Genetic architecture of mandible shape in mice: effects of quantitative trait loci analyzed by geometric morphometrics. Genetics 157 (2001) 785-802
117. Klingenberg C.P., Leamy L.J., and Cheverud J.M. Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandible. Genetics 166 (2004) 1909-1921
118. Klingenberg C.P., and Leamy L.J. Quantitative genetics of geometric shape in the mouse mandible. Evol. Int. J. Org. Evol. 55 (2001) 2342-2352
119. Klingenberg C.P., and Monteiro L.R. Distances and directions in multidimensional shape spaces: implications for morphometric applications. Syst. Biol. 54 (2005) 678-688
120. Kottler M.S., Rosenthal A.R., and Falconer D.G. Analog vs. digital photogrammetry for optic cup analysis. Invest. Ophthalmol. Vis. Sci 15 (1976) 651-654
121. Kuhl F G.C. Elliptic Fourier features of a closed contour. Comput. Graph. Image Process. 18 (1982) 236-258
122. Lele S. Some comments on coordinate-free and scale-invariant methods in morphometrics. Am. J. Phys. Anthropol. 85 (1991) 407-417
123. Lele S., and Richtsmeier J.T. Euclidean distance matrix analysis: a coordinate-free approach for comparing biological shapes using landmark data. Am. J. Phys. Anthropol. 86 (1991) 415-427
124. Lestrel P.E. Method for analyzing complex two-dimensional forms: elliptical Fourier functions. Am. J. Hum. Biol. 1 (1989) 149-164
125. Littmann H. Determination of the real size of an object on the fundus of the living eye. Klin Monatsbl Augenheilkd 180 (1982) 286-289
126. Lockwood C.A., Kimbel W.H., and Lynch J.M. Morphometrics and hominoid phylogeny: support for a chimpanzee-human clade and differentiation among great ape subspecies. Proc. Natl. Acad. Sci. U.S.A 101 (2004) 4356-4360
127. MacLeod N. Generalizing and extending the eigenshape method of shape space visualization and analysis. Paleobiology 25 (1999) 107-138
128. Marcus L.F. Traditional morphometrics. In: Rohlf F.J., and Bookstein F.L. (Eds). Proceedings of the Michigan Morphometrics Workshop. Special Publication Number 2 (1990), University of Michigan Museum of Zoology, Ann Arbor 77-122
129. Marcus L.E., Hingst-Zaher E., and Zaher H. Application of landmark morphometrics to skulls representing the orders of living mammals. Hystrix Ital. J. Mammal. 11 (2000) 27-41
130. Marquis R., Schmittbuhl M., Mazzella W.D., and Taroni F. Quantification of the shape of handwritten characters: a step to objective discrimination between writers based on the study of the capital character O. Forensic Sci. Int. 150 (2005) 23-32
131. Martinón-Torres M., Bastir M., Bermúdez de Castro J.M., Gómez A., Sarmiento S., Muela A., and Arsuaga J.L. Hominin lower second premolar morphology: evolutionary inferences through geometric morphometric analysis. J. Hum. Evol. 50 (2006) 523-533
132. McIntyre G.T., and Mossey P.A. Size and shape measurement in contemporary cephalometrics. Eur. J. Orthod. 25 (2003) 231-242
133. McLellan T., and Endler J.A. The relative success of some methods for measuring and describing the shape of complex objects. Syst. Biol. 47 (1998) 264-281
134. Moreno-Montañés J., Antón A., García N., Mendiluce L., Ayala E., and Sebastián A. Glaucoma probability score vs Moorfields classification in normal, ocular hypertensive, and glaucomatous eyes. Am. J. Ophthalmol. 145 (2008) 360-368
135. Morgan J.E., Sheen N.J., North R.V., Choong Y., and Ansari E. Digital imaging of the optic nerve head: monoscopic and stereoscopic analysis. Br. J. Ophthalmol. 89 (2005) 879-884
136. Morgan J.E., Sheen N.J., North R.V., Goyal R., Morgan S., Ansari E., and Wild J.M. Discrimination of glaucomatous optic neuropathy by digital stereoscopic analysis. Ophthalmology 112 (2005) 855-862
137. Nagorsen, D.W., Cardini, A., 2009. Tempo and mode of evolutionary divergence in modern and Holocene Vancouver Island marmots (Marmota vanvouverensis). J. Zool. Systemat. Evol. Res., doi:10.1111/j.1439-0469.2008.00503.x.
138. Neubauer A.S., Krieglstein T.R., Chryssafis C., Thiel M., and Kampik A. Comparison of optical coherence tomography and fundus photography for measuring the optic disc size. Ophthalmic Physiol. Opt. 26 (2006) 13-18
139. O'Higgins P. Methodological issues in the description of forms. In: Lestrel P.E. (Ed). Fourier Descriptors and their Applications (1997), Cambridge University Press, Cambridge 74-105
140. O'Higgins P. Ontogeny and phylogeny: morphometric approaches to the study of skeletal growth and evolution. In: Chaplain M.A.J., Singh G.D., and McLachlan J. (Eds). On Growth and Form: Spatio-temporal Patterning in Biology (1999), John Wiley and Sons, Chichester 373-393
141. O'Higgins P. The study of morphological variation in the hominid fossil record: biology, landmarks and geometry. J. Anat. 197 (2000) 103-120
142. Oddone, F., Centofanti, M., Rossetti, L., Iester, M., Fogagnolo, P., Capris, E., Manni, G., 2008. Exploring the Heidelberg Retinal Tomograph 3 diagnostic accuracy across disc sizes and glaucoma stages: a multicenter study. Ophthalmology 115 (8), 1358-1365.
143. Perez S.I., Bernal V., and Gonzalez P.N. Differences between sliding semi-landmark methods in geometric morphometrics, with an application to human craniofacial and dental variation. J. Anat. 208 (2006) 769-784
144. Pilbeam D. Hominoid systematics: the soft evidence. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 10684-10686
145. Polly P.D. Variability in mammalian dentitions: size-related bias in the coefficient of variation. Biol. J. Linn. Soc. 64 (1998) 83-99
146. Polly P.D. Adaptive zones and the pinniped ankle: a 3D quantitative analysis of carnivoran tarsal evolution. In: Sargis E., and Dagosto M. (Eds). Mammalian Evolutionary Morphology: a Tribute to Frederick S. Szalay (2008), Springer, Dordrecht, The Netherlands 165-194
147. Ponce de León M.S., and Zollikofer C.P. Neanderthal cranial ontogeny and its implications for late hominid diversity. Nature 412 (2001) 534-538
148. Pretorius E., Steyn M., and Scholtz Y. Investigation into the usability of geometric morphometric analysis in assessment of sexual dimorphism. Am. J. Phys. Anthropol. 129 (2006) 64-70
149. Quigley H.A., Brown A.E., Morrison J.D., and Drance S.M. The size and shape of the optic disc in normal human eyes. Arch. Ophthalmol. 108 (1990) 51-57
150. Ramakrishnan R., Kader M.A., and Budde W.M. Optic disc morphometry with optical coherence tomography: comparison with planimetry of fundus photographs and influence of parapapillary atrophy and pigmentary conus. Indian J. Ophthalmol. 53 (2005) 187-191
151. Ramrattan R.S., Wolfs R.C., Jonas J.B., Hofman A., and de Jong P.T. Determinants of optic disc characteristics in a general population: the Rotterdam Study. Ophthalmology 106 (1999) 1588-1596
152. Richtsmeier J.T., DeLeon V.B., and Lele S.R. The promise of geometric morphometrics. Am. J. Phys. Anthropol. Suppl. 35 (2002) 63-91
153. Rohlf F.J. Relationships among eigenshape analysis, Fourier analysis, and analysis of coordinates. Math. Geol. 18 (1986) 845-854
154. Rohlf F.J. Fitting curves to outlines. In: Rohlf F.J., and Bookstein F.L. (Eds). Proceedings of the Michigan Morphometrics Workshop. Special Publication Number 2 (1990), University of Michigan Museum of Zoology, Ann Arbor 167-177
155. Rohlf F.J. On applications of geometric morphometrics to studies of ontogeny and phylogeny. Syst. Biol. 47 (1998) 147-158
156. Rohlf F.J. Statistical power comparisons among alternative morphometric methods. Am. J. Phys. Anthropol. 111 (2000) 463-478
157. Rohlf F.J. On the use of shape spaces to compare morphometric methods. Hystrix Ital. J. Mammal. 11 (2000) 9-25
158. Rohlf, F.J., 2003. tpsRelw Version 1.29.
159. Rohlf F.J., and Marcus L.F. A revolution in morphometrics. Trends Ecol. Evol. 8 (1993) 129-132
160. Rohlf F.J., and Slice D. Extensions of the Procrustes method for the optimal superimposition of landmarks. Syst. Zool. 39 (1990) 40-59
161. Sampson P.D., Bookstein F.L., Sheehan H., and Bolson E.L. Eigenshape analysis of left ventricular outlines from contrast ventriculograms. In: Marcus L.F., Corti M., Loy A., Naylor G.J.P., and Slice D.E. (Eds). Advances in Morphometrics (1996), Plenum, New York 131-152
162. Saruhan A., Orgül S., Koçak I., Prünte C., and Flammer J. Descriptive information of topographic parameters computed at the optic nerve head with the Heidelberg retina tomograph. J. Glaucoma 7 (1998) 420-429
163. Schmittbuhl M., Le Minor J.M., Allenbach B., and Schaaf A. Shape of the piriform aperture in Gorilla gorilla, Pan troglodytes, and modern Homo sapiens: characterization and polymorphism analysis. Am. J. Phys. Anthropol. 106 (1998) 297-310
164. Schmittbuhl M., Le Minor J.-M., Schaaf A., and Mangin P. The human mandible in lateral view: elliptical Fourier descriptors of the outline and their morphological analysis. Ann. Anat. 184 (2002) 199-207
165. Schuman J.S., Wollstein G., Farra T., Hertzmark E., Aydin A., Fujimoto J.G., and Paunescu L.A. Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy. Am. J. Ophthalmol. 135 (2003) 504-512
166. Sheets D.H. IMP - Integrated Morphometrics Package (2003), Department of Physics, Canisius College, Buffalo, NY
167. Sheets D.H., Keonho K., and Mitchell C.E. A combined landmark and outline-based approach to ontogenetic shape change in the Ordovician Trilobite Triarthrus becki. In: Elewa A. (Ed). Applications of Morphometrics in Paleontology and Biology (2004), Springer, New York 67-81
168. Sherwood R.J., Hlusko L.J., Duren D.L., Emch V.C., and Walker A. Mandibular symphysis of large-bodied hominoids. Hum. Biol. 77 (2005) 735-759
169. Sigal I.A., Flanagan J.G., Tertinegg I., and Ethier C.R. Finite element modeling of optic nerve head biomechanics. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4378-4387
170. Sigal I.A., Flanagan J.G., and Ethier C.R. Factors influencing optic nerve head biomechanics. Invest. Ophthalmol. Vis. Sci. 46 (2005) 4189-4199
171. Sigal, I.A., Flanagan, J.G., Tertinegg, I., Ethier, C.R., 2009a. Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry. Biomech. Model. Mechanobiol. 8 (2), 85-98.
172. Sigal, I.A., Flanagan, J.G., Tertinegg, I., Ethier, C.R., 2009b. Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties. Biomech. Model. Mechanobiol. 8 (2), 99-109.
173. Sihota R., Srinivasan G., Dada T., Gupta V., Ghate D., and Sharma A. Is the ISNT rule violated in early primary open-angle glaucoma-a scanning laser tomography study. Eye 22 (2008) 819-824
174. Slice D.E. Modern Morphometrics in Physical Anthropology (2005), Kluwer Academic/Plenum, New York
175. Slice D. Geometric morphometrics. Annu. Rev. Anthropol. 36 (2007) 261-281
176. Spencer A.F., and Vernon S.A. Optic disc measurement: a comparison of indirect ophthalmoscopic methods. Br. J. Ophthalmol. 79 (1995) 910-915
177. Swindale N.V., Stjepanovic G., Chin A., and Mikelberg F.S. Automated analysis of normal and glaucomatous optic nerve head topography images. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1730-1742
178. Tay E., Seah S.K., Chan S.-P., Lim A.T.H., Chew S.-J., Foster P.J., and Aung T. Optic disk ovality as an index of tilt and its relationship to myopia and perimetry. Am. J. Ophthalmol. 139 (2005) 247-252
179. Thompson D.A. On Growth and Form (1917), Cambridge University Press, London
180. Tomlinson A., and Phillips C.I. Ovalness of the optic cup and disc in the normal eye. Br. J. Ophthalmol. 58 (1974) 543-547
181. Trip S.A., Schlottmann P.G., Jones S.J., Garway-Heath D.F., Thompson A.J., Plant G.T., and Miller D.H. Quantification of optic nerve head topography in optic neuritis: a pilot study. Br. J. Ophthalmol. 90 (2006) 1128-1131
182. Uchida H., Brigatti L., and Caprioli J. Detection of structural damage from glaucoma with confocal laser image analysis. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2393-2401
183. Wagner G.P. Homologues, natural kinds and the evolution of modularity. Am. Zool. 36 (1996) 36-43
184. Wagner G.P., Pavlicev M., and Cheverud J.M. The road to modularity. Nat. Rev. Genet. 8 (2007) 921-931
185. Wang L., Damji K.F., Munger R., Jonasson F., Arnarsson A., Sasaki H., and Sasaki K. Increased disk size in glaucomatous eyes vs normal eyes in the Reykjavik eye study. Am. J. Ophthalmol. 135 (2003) 226-228
186. Wang Y., Xu L., and Jonas J.B. Shape of the neuroretinal rim and its correlations with ocular and general parameters in adult Chinese: the Beijing eye study. Am. J. Ophthalmol. 144 (2007) 462-464
187. Waters J.A. Quantification of shape by use of Fourier analysis: the Mississippian blastoid genus Pentremites. Paleobiology 3 (1977) 288-299
188. Willmore K.E., Zelditch M.L., Young N., Ah-Seng A., Lozanoff S., and Hallgrímsson B. Canalization and developmental stability in the Brachyrrhine mouse. J. Anat 208 (2006) 361-372
189. Wong D., Liazos S., Mehta J., and Farnell D. Macular translocation surgery: computer simulation of visual perception. Graefes Arch. Clin. Exp. Ophthalmol. 246 (2008) 831-836
190. Xu L., Wang Y., Yang H., Zhang L., and Jonas J.B. Size of the neuroretinal rim and optic cup and their correlations with ocular and general parameters in adult Chinese. The Beijing eye study. Br. J. Ophthalmol. 91 (2007) 1616-1619
191. Yang H., Downs J.C., Girkin C.A., Sakata L., Bellezza A., Thompson H., and Burgoyne C.F. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness. Invest. Ophthalmol. Vis. Sci. 48 (2007) 4597-4607
192. Yang H., Downs J.C., Bellezza A., Thompson H., and Burgoyne C.F. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: prelaminar neural tissues and cupping. Invest. Ophthalmol. Vis. Sci. 48 (2007) 5068-5084
193. Zangwill L.M., Jain S., Racette L., Ernstrom K.B., Bowd C., Medeiros F.A., Sample P.A., and Weinreb R.N. The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg Retina Tomograph Glaucoma Probability Score. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2653-2660
194. Zelditch M.L., Bookstein F.L., and Lundrigan B.L. Ontogeny of integrated skull growth in the cotton rat Sigmodon fulviventer. Evolution 46 (1992) 1164-1180
195. Zelditch M.L., Swiderski D.L., Sheets D.H., and Fink W.L. Geometric Morphometrics for Biologists (2004), Academic Press, London
196. Zhu G., Hewitt A.W., Ruddle J.B., Kearns L.S., Brown S.A., Mackinnon J.R., Chen C.Y., Hammond C.J., Craig J.E., Montgomery G.W., Martin N.G., and Mackey D.A. Genetic dissection of myopia evidence for linkage of ocular axial length to chromosome 5q. Ophthalmology 115 (2008) 1053-1057