The effect of the MHC locus on autoantibodies in type 1 diabetes

Journal of Medical Genetics

Volumn 46, Issue 7, 2009, Pages 469-471

  Qu, H Q ^a   Polychronakos, C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA C ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; ISLET 2 ANTIBODY; ISLET ANTIGEN 2; UNCLASSIFIED DRUG;

ARTICLE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PARENT; PRIORITY JOURNAL;

ADOLESCENT; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HISTOCOMPATIBILITY ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; MALE;

EID: 67650501545     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmg.2009.066647     Document Type: Article

References (15)

1. Atkinson MA, Maclaren NK. Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 1993;92:1608-16.
2. Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Bingley PJ, Eisenbarth GS. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. Diabetes 1998;47:1857-66.
3. Genovese S, Bonfanti R, Bazzigaluppi E, Lampasona V, Benazzi E, Bosi E, Chiumello G, Bonifacio E. Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia 1996;39:1223-6.
4. Sanjeevi CB, Hagopian WA, Landin-Olsson M, Kockum I, Woo W, Palmer JP, Lernmark A, Dahlquist G. Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8. Tissue Antigens 1998;51:281-6.
5. Williams AJ, Aitken RJ, Chandler MA, Gillespie KM, Lampasona V, Bingley PJ. Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLADQA in autoimmunity to IA-2. Diabetologia 2008;51:1444-8.
6. Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark A, Breslow N, Dahlquist G, Blohme G. Genetic effects on agedependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 2002;51:1346-55.
7. Rich SS, Concannon P, Erlich H, Julier C, Morahan G, Nerup J, Pociot F, Todd JA. The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci 2006;1079:1-8.
8. Frank D. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003;25:115-21.
9. Taplin CE, Barker JM. Autoantibodies in type 1 diabetes. Autoimmunity 2008;41:11-8.
10. Stewart CA, Horton R, Allcock RJN, Ashurst JL, Atrazhev AM, Coggill P, Dunham I, Forbes S, Halls K, Howson JMM, Humphray SJ, Hunt S, Mungall AJ, Osoegawa K, Palmer S, Roberts AN, Rogers J, Sims S, Wang Y, Wilming LG, Elliott JF, de Jong PJ, Sawcer S, Todd JA, Trowsdale J, Beck S. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004;14:1176-87.
11. Lan MS, Wasserfall C, Maclaren NK, Notkins AL. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1996;93:6367-70.
12. Lampasona V, Bearzatto M, Genovese S, Bosi E, Ferrari M, Bonifacio E. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen. J Immunol 1996;157:2707-11.
13. Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, Notkins AL. Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes 2002;51:1842-50.
14. Sidney J, del Guercio MF, Southwood S, Sette A. The HLA molecules DQA1*0501/ B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity. J Immunol 2002;169:5098-108.
15. Nejentsev S, Howson JMM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007;450:887-92.