Frequency, characteristics, and risk factors for amiodarone neurotoxicity

Archives of Neurology

Volumn 66, Issue 7, 2009, Pages 865-869

  Orr, Carolyn F ^a   Ahlskog, J Eric ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE;

ADULT; AGED; ARTICLE; ATAXIA; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FATTY LIVER; FEMALE; GAIT DISORDER; HEADACHE; HEART ARRHYTHMIA; HEART ATRIUM ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; INCIDENCE; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MUSCLE WEAKNESS; NEUROTOXICITY; OSTEOARTHRITIS; PARKINSONISM; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; RETROSPECTIVE STUDY; RISK FACTOR; TOXIC HEPATITIS; TREATMENT DURATION; TREATMENT OUTCOME; TREMOR; UNITED STATES;

AGED; AGED, 80 AND OVER; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; FEMALE; HEART DISEASES; HUMANS; MALE; MEDICAL RECORDS; NEUROLOGIC EXAMINATION; NEUROTOXICITY SYNDROMES; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 67650496214     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2009.96     Document Type: Article

References (20)

1. Morady F, Sauve MJ, Malone P, et al. Long-term efficacy and toxicity of highdose amiodarone therapy for ventricular tachycardia or ventricular fibrillation. Am J Cardiol. 1983;52(8):975-979.
2. Greene HL, Graham EL, Werner JA, et al. Toxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmias. J Am Coll Cardiol. 1983;2(6):1114-1128.
3. Raeder EA, Podrid PJ, Lown B. Side effects and complications of amiodarone therapy. Am Heart J. 1985;109(5, pt 1):975-983.
4. Charness ME, Morady F, Scheinman MM. Frequent neurologic toxicity associated with amiodarone therapy. Neurology. 1984;34(5):669-671.
5. Coulter DM, Edwards IR, Savage RL. Survey of neurological problems with amiodarone in the New Zealand Intensive Medicines Monitoring Programme. N Z Med J. 1990;103(885):98-100.
6. Palakurthy PR, Iyer V, Meckler RJ. Unusual neurotoxicity associated with amiodarone therapy. Arch Intern Med. 1987;147(5):881-884.
7. Arnaud A, Neau JP, Rivasseau-Jonveaux T, Marechaud R, Gil R. Neurological toxicity of amiodarone: 5 case reports [in French]. Rev Med Interne. 1992;13(6):419-422.
8. Werner EG, Olanow CW. Parkinsonism and amiodarone therapy. Ann Neurol. 1989;25(6):630-632.
9. Katrak PH. Stroke patients: do they have a predilection for extrapyramidal side effects from amiodarone? Arch Phys Med Rehabil. 1999;80(1):112-114.
10. Vassallo P, Trohman RG. Prescribing amiodarone: an evidence-based review of clinical indications. JAMA. 2007;298(11):1312-1322.
11. Anderson NE, Lynch NM, O'Brien KP. Disabling neurological complications of amiodarone. Aust N Z J Med. 1985;15(3):300-304.
12. Ahmed S, Rienstra M, Crijns HJ, et al; CONVERT Investigators. Continuous vs episodic prophylactic treatment with amiodarone for the prevention of atrial fibrillation: a randomized trial. JAMA. 2008;300(15):1784-1792.
13. Cairns JA, Connolly SJ, Roberts R, Gent M; Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators. Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Lancet. 1997;349(9053):675-682.
14. Julian DG, Camm AJ, Frangin G, et al; European Myocardial Infarct Amiodarone Trial Investigators. Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet. 1997;349(9053):667-674.
15. Vorperian VR, Havighurst TC, Miller S, January CT. Adverse effects of low dose amiodarone: a meta-analysis. J Am Coll Cardiol. 1997;30(3):791-798.
16. Zimetbaum P. Amiodarone for atrial fibrillation. N Engl J Med. 2007;356(9):935-941.
17. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-245.
18. Goldschlager N, Epstein AE, Naccarelli GV, et al; Practice Guidelines Subcommittee, North American Society of Pacing and Electrophysiology (HRS). A practical guide for clinicians who treat patients with amiodarone: 2007. Heart Rhythm. 2007;4(9):1250-1259.
19. Fogoros RN, Anderson KP, Winkle RA, Swerdlow CD, Mason JW. Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias. Circulation. 1983;68(1):88-94.
20. Goldschlager N, Epstein AE, Naccarelli G, Olshansky B, Singh B; Practice Guidelines Subcommittee, North American Society of Pacing and Electrophysiology. Practical guidelines for clinicians who treat patients with amiodarone. Arch Intern Med. 2000;160(12):1741-1748.