Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia: Is there a link?

Current Sports Medicine Reports

Volumn 7, Issue 2, 2008, Pages 74-80

  Muldoon, Sheila ^a,b   Deuster, Patricia ^b   Voelkel, Maria ^a   Capacchione, John ^a   Bunger, Rolf ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CREATINE KINASE; DANTROLENE; HALOTHANE; MYOGLOBIN; POTASSIUM; RYANODINE RECEPTOR 1;

ANESTHESIA INDUCTION; AUTOSOMAL DOMINANT INHERITANCE; BEHAVIOR CHANGE; BIOASSAY; CARDIOVASCULAR DISEASE; COMA; CONTROLLED STUDY; CONVALESCENCE; CORE TEMPERATURE; DEATH; DELIRIUM; DISEASE ASSOCIATION; DYSPNEA; EXERCISE TEST; FAMILY HISTORY; FEVER; FLUID INTAKE; GENE MUTATION; HEAT INJURY; HEAT STROKE; HIGH RISK POPULATION; HUMAN; HYDRATION; HYPERCAPNIA; HYPERMETABOLISM; HYPERTHERMIA; INFLUENZA; KIDNEY INJURY; LIVER INJURY; MALIGNANT HYPERTHERMIA; MENTAL DISEASE; METABOLIC ACIDOSIS; MORTALITY; MUSCLE CONTRACTILITY; MUSCLE RIGIDITY; MUSCULOSKELETAL INJURY; MUSCULOSKELETAL PAIN; MYOGLOBINURIA; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PHYSICAL ACTIVITY; RESPIRATORY DISTRESS; RESPIRATORY TRACT INFECTION; REVIEW; RHABDOMYOLYSIS; SEIZURE; STREPTOCOCCUS PNEUMONIA; TACHYCARDIA; THERMAL EXPOSURE; THERMOGENESIS;

HEAT EXHAUSTION; HUMANS; MALIGNANT HYPERTHERMIA; RHABDOMYOLYSIS;

EID: 67650493913     PISSN: 1537890X     EISSN: 15378918     Source Type: Journal    
DOI: 10.1097/01.CSMR.0000313392.79569.e7     Document Type: Review

References (36)

1. Hopkins, P.M. Is there a link between malignant hyperthermia and exertional heat illness? Br. J. Sports Med. 41:283-284, 2007.
2. Allen, G.C., M.G. Larach, and A.R. Kunselman. The sensitivity and specificity of the caffeine-halothane contracture test: A report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS. Anesthesiology.88: 579-588, 1998.
3. Ording, H., V. Brancadoro, S. Cozzolino, et al. In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyper- thermia Group. Acta. Anaesthesiol. Scand. 41:955-966, 1997.
4. Ording, H. Incidence of malignant hyperthermia in Denmark. Anesth. Analg. 64:700-704, 198.
5. McDermott, B., D. Casa, S. Yeargin, et al. Recovery and return to activity following exertional heat stroke: Considerations for the sports medicine staff. J. Sport Rehabil. 16:163-181, 2007.
6. Carter, R. 3rd, S.N. Cheuvront, and M.N. Sawka. A case report of idiosyncratic hyperthermia and review of U.S. Army heat stroke hospitalizations. J. Sport Rehabil. 16:238-243, 2007.
7. O'Connor, F., and P. Deuster. Rhabdomyolysis. In: Cecil Medicine, 23rd ed. J. Drazen (Ed.). Philadelphia: Saunders Elsevier, 2008, pp. 798-802.
8. Warren, J.D., P.C. Blumbergs, and P.D. Thompson. Rhabdomyolysis:A review. Muscle Nerve. 25:332-347, 2002.
9. Lin, H., W. Chie, and H. Lien. Epidemiological analysis of factors influencing an episode of exertional rhabdomyolysis in high school students. Am. J. Sports Med. 34:481-486, 2006.
10. Jardon, O.M. Physiologic stress, heat stroke, malignant hyperthermia: A perspective. Mil. Med. 147:8-14, 1982.
11. Muldoon, S., P. Deuster, B. Brandom, and R. Bunger. Is there a link between malignant hyperthermia and exertional heat illness? Exerc. Sport Sci. Rev. 32:174-179, 2004.
12. Porter, A.M. Collapse from exertional heat illness: implications and subsequent decisions. Mil. Med. 168:76-81, 2003.
13. Rosenberg, H. NMS, EHS, and MH. American Journal of Anesthesiology. 28:382-385, 2001.
14. Muldoon, S., R. Bunger, P. Deuster, and N. Sambuughin. Identification of risk factors for exertional heat illness: a brief commentary on genetic testing. J. Sports Rehabil. 16:222-226, 2007.
15. Ogletree, J.W., J.F. Antognini, and G.A. Gronert. Postexercise muscle cramping associated with positive malignant hyperthermia contracture testing. Am. J. Sports Med. 24:49-51, 1996.
16. Hunter, S., H. Rosenberg, and G. Tuttle. Malignant hyperthermia in a college football player. Phys. Sportsmed. 15:77-84, 1987.
17. Kochling, A., F. Wappler, G. Winkler, and J.S. Schulte am Esch. Rhabdomyolysis following severe physical exercise in a patient with predisposition to malignant hyperthermia. Anaesth. Intensive Care. 26: 315-318, 1998.
18. Hackl, W., M. Winkler, W. Mauritz, et al. Muscle biopsy for diagnosis of malignant hyperthermia susceptibility in two patients with severe exercise-induced myolysis. Br. J. Anaesth. 66:138-140, 1991.
19. Fink, E., B.W. Brandom, and K.D. Torp. Heatstroke in the super-sized athlete. Pediatr. Emerg. Care. 22:510-513, 2006.
20. 31Phosphorus magnetic resonance spectroscopy characterization of muscular metabolic anomalies in patients with malignant hyperthermia: Application to diagnosis. Anesthesiology. 88:96-107, 1998.
21. Bendahan, D., G. Kozak-Ribbens, S. Confort-Gouny, et al. A non- invasive investigation of muscle energetics supports similarities be-tween exertional heat stroke and malignant hyperthermia. Anesth. Analg. 93:683-689, 2001.
22. Figarella-Branger, D., G. Kozak-Ribbens, L. Rodet, et al. Pathological findings in 165 patients explored for malignant hyperthermia susceptibility. Neuromuscul. Disord. 3:553-556, 1993.
23. Hopkins,P.M.,F.R.Ellis,andP.J.Halsall. Evidence for related myopathies in exertional heat stroke and malignant hyperthermia. Lancet. 338:1491-1492, 1991.
24. Tobin, J.R., D.R. Jason, V.R. Challa, et al. Malignant hyperthermia and apparent heat stroke. JAMA. 286:168-169, 2001.
25. Ryan, J.F., and L.G. Tedeschi. Sudden unexplained death in a patient with a family history of malignant hyperthermia. J. Clin. Anesth.9:66-68, 1997.
26. Poels, P.J., E.M. Joosten, R.C. Sengers, et al. In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis. J. Neurol. Sci. 105:67-72, 1991.
27. Haverkort-Poels, P.J., E.M. Joosten, and W. Ruitenbeek. Prevention of recurrent exertional rhabdomyolysis by dantrolene sodium. Muscle Nerve. 10:45-46, 1987.
28. Wappler, F., M. Fiege, M. Steinfath, et al. Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomy- olysis. Anesthesiology. 94:95-100, 2001.
29. Loke, J., N. Kraeva, and D. MacLennan. Mutations in RyR1 gene associated with malignant hyperthermia and a non-anaesthetic pheno-type. Can J Anaesth. 5444609, 2007.
30. Davis,M.,R.Brown,A.Dickson, et al. Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees. Br. J. Anaesth. 88:508-515, 2002.
31. Weglinski, M.R., D.J. Wedel, and A.G. Engel. Malignant hyperthermia testing in patients with persistently increased serum creatine kinase levels. Anesth. Analg. 84:1038-1041, 1997.
32. Allsop, P., L. Jorfeldt, H. Rutberg, et al. Delayed recovery of muscle pH after short duration, high intensity exercise in malignant hyperthermia susceptible subjects. Br. J. Anaesth. 66:541-545, 1991.
33. Moran, D., Y. Heled, L. Still, et al. Assessment of heat tolerance for post exertional heat stroke individuals. Med. Sci. Monit.10:CR252- CR257, 2004.
34. Heled, Y., M.S. Bloom, T.J. Wu, et al. CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise. J. Appl. Physiol. 103:504-510, 2007.
35. Armstrong, L., and R. Lopez. Return to exercise training after heat exhaustion. J. Sport Rehabil. 16:182-189, 2007.
36. Cleary, M., D. Ruiz, L. Eberman, et al. Dehydration, cramping, and exertional rhabdomyolysis: A case report with suggestions for recovery. J. Sport Rehabil. 16:244-259, 2007.