Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?

Pediatric Blood and Cancer

Volumn 52, Issue 7, 2009, Pages 796-803

  Biswas, Swethajit ^a   Burke, Amos ^a   Cherian, Sheen ^a   Williams, Denise ^a   Nicholson, James ^a   Horan, Gail ^a   Jefferies, Sarah ^a   Williams, Michael ^a   Earl, Helena M ^a,b   Burnet, Neil G ^a,b   Hatcher, Helen ^a,b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Medulloblastoma; Packer regimen chemotherapy; Prognosis; Supratentorial primitive neuroectodermal tumors

Indexed keywords

CISPLATIN; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; LOMUSTINE; VINCRISTINE;

ADOLESCENT; ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CLINICAL ARTICLE; CLINICAL STUDY; COMPARATIVE STUDY; CRANIOSPINAL IRRADIATION; DEMOGRAPHY; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; INFANT; MALE; MEDICAL RECORD; MULTIPLE CYCLE TREATMENT; NEUROECTODERM TUMOR; OVERALL SURVIVAL; PINEAL BODY TUMOR; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; STEM CELL TRANSPLANTATION; SUPRATENTORIAL PRIMITIVE NEUROECTODERMAL TUMOR; SURVIVAL RATE; SURVIVAL TIME; TREATMENT INDICATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CEREBELLAR NEOPLASMS; CHILD; CISPLATIN; CRANIAL IRRADIATION; FOLLOW-UP STUDIES; HUMANS; LOMUSTINE; MEDULLOBLASTOMA; NEOPLASM STAGING; NEUROECTODERMAL TUMORS, PRIMITIVE; RETROSPECTIVE STUDIES; SUPRATENTORIAL NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME; VINCRISTINE; YOUNG ADULT;

EID: 67650484259     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21899     Document Type: Article

References (26)

1. Gurney JG, Bunin GR. CNS and miscellaneous intracranial and intraspinal neoplasms. In: Ries LAG, Kosary CL, Hankey BF, editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. NIH Pub No 99-4649. Bethesda: National Cancer Institute; 1999. pp. 51- 63.
2. Ohba S, Yoshida K, Hirose Y, et al. A supratentorial primitive neuroectodermal tumor in an adult: A case report and review of the literature. J Neurooncol 2008;86:217-224. (Pubitemid 350263421)
3. Packer RJ, Sutton LN, Elterman R, et al. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU and vincristine chemotherapy. J Neurosurg 1994;81:690-698. (Pubitemid 24328694)
4. Timmermann B, Kortmann RD, Kuhl J, et al. Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: Results of the prospective German brain tumor trials HIT 88/89 and 91. J Clin Oncol 2002;20:842-849. (Pubitemid 34111394)
5. Spalding AC, Hamstra DA. Letter to the Editor: Radiation therapy reduces local failure and improves overall survival in sPNET. Pediatr Blood Cancer 2008;51:148. (Pubitemid 351717414)
6. Pizer BL,Weston CL, Robinson KJ, et al. Analysis of patients with supratentorial primitive neuro-ectodermal tumours entered into the SIOP/UKCCSG PNET 3 study. Eur J Cancer 2006;42:1120-1128.
7. Pizer B, Clifford S. Medulloblastoma: New insights into biology and treatment. Arch Dis Child 2008;93:137-144.
8. Pfister S, Remke M, Toedt G, et al. Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas. Genes Chromos Cancer 2007;46:839-851.
9. MacDonald TJ, Rood BR, Santi MR, et al. Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors. Oncologist 2003;8:174-186. (Pubitemid 36428283)
10. Becker LE, Giangaspero F, Rorke LB, et al. Embryonal tumours. In: Kleihues P, Cavenee WK, editors. World health organization classification of tumours, pathology and genetics of tumours of the nervous system. Lyon, France: IARC Press; 2000. pp. 123- 148.
11. Chang CH, Housepian EM, Herbert C. An operative staging system and a megavoltage radiotherpeutic technic for cerebellar medulloblastoma. Radiology 1969;93:1351-1369.
12. Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase II study. J Clin Oncol 1999;17:832-845. (Pubitemid 29109313)
13. Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group study. J Clin Oncol 1999;17:2127-2136. (Pubitemid 29318845)
14. Bouffet E. Embryonal tumours of the central nervous system. Eur J Cancer 2002;38:1112-1120. (Pubitemid 34468017)
15. Reddy A, Janss A, Phillips P, et al. Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy. Cancer 2000;88:2189-2193. (Pubitemid 30233223)
16. Milinkevitch S, Pasco-Papon A, Mercier P, et al. Supratentorial primitive neuroectodermal tumours of the brain: Multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients. Histopathology 2005;46:403-412.
17. Johnston DL, Keene DL, Lafay-Cousin L, et al. Supratentorial primitive neuroectodermal tumours: A Canadian pediatric brain tumor consortium report. J Neurooncol 2008;86:101-108. (Pubitemid 350263439)
18. Fangusaro J, Finlay J, Sposto R, et al. Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): Report of the Head Start I and II experience. Pediatr Blood Cancer 2008;50:312-318.
19. Moe MC, Varghese M, Danilov AI, et al. Multipotent progenitor cells from the adult human brain: Neurophysiological differentiation to mature neurons. Brain 2005;128(Pt 9):2189-2199. (Pubitemid 41253285)
20. Tomita T, McLone DG, Yasue M. Cerebral primitive neuroectodermal tumors in childhood. J Neurooncol 1988;6:233-243. (Pubitemid 19022020)
21. The Cancer, Genome Atlas, Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-1068.
22. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus Concomitant and adjuvant Temozolomide for Glioblastoma. N Engl J Med 2005;352:987-996. (Pubitemid 40349501)
23. Albertella MR, Loadman PM, Jones PH, et al. Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: Results of a Phase I study. Clin Cancer Res 2008;14:1096-1104. (Pubitemid 351302556)
24. Siim BG, Pruijn FB, Sturman JR, et al. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Cancer Res 2004;64:736-742. (Pubitemid 38120917)
25. Muhlisch J, Schwering A, Grotzer M, et al. Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical/rhaboid tumors (AT/RT) of childhood. Oncogene 2006;25: 1111-1117. (Pubitemid 43277018)
26. HIT, 2000. Trial: Randomized multicentric prospective phase-III-trial for the treatment of children and adolescents with intracranial PNET/Medulloblastoma and Ependymoma. http://zv.uni-wuerzburg. de/forschungsbericht/FOBE-akt/LS-30409010/HIT%202000% 20%20Multizentrische%20Phase-III-Therapieoptimierungsstudie- E.htm.