Should we step-up or step-down in the treatment of new-onset dyspepsia in primary care?

Polskie Archiwum Medycyny Wewnetrznej

Volumn 119, Issue 6, 2009, Pages 391-396

  Ford, Alexander C ^a   Moayyedi, Paul ^b  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antacids; Dyspepsia; Endoscopy; Helicobacter pylori; Proton pump inhibitors

Indexed keywords

ANTACID AGENT; PROTON PUMP INHIBITOR;

CLINICAL FEATURE; COST EFFECTIVENESS ANALYSIS; DYSPEPSIA; ENDOSCOPY; GROUPS BY AGE; HELICOBACTER PYLORI; HUMAN; NETHERLANDS; PHYSICIAN; PREVALENCE; PRIMARY MEDICAL CARE; REVIEW; WEIGHT REDUCTION;

EID: 67650483722     PISSN: 00323772     EISSN: None     Source Type: Journal    
DOI: 10.20452/pamw.717     Document Type: Review

References (41)

1. Marwaha A, Ford AC, Lim A, Moayyedi P. Worldwide prevalence of dyspepsia: Systematic review and meta-analysis. Gastroenterology, (in press) 2009.
2. Penston JG, Pounder RE. A survey of dyspepsia in Great Britain. Aliment Pharmacol Ther. 1996; 10: 83-89.
3. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ 3rd. Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology. 1992; 102: 1259-1268.
4. Levin TR, Schmittdiel JA, Kunz K, et al. Costs of acid-related disorders to a health maintenance organization. Am J Med. 1997; 103: 520-528. (Pubitemid 28018655)
5. Moayyedi P, Mason J. Clinical and economic consequences of dyspepsia in the community. Gut. 2002; 50 (Suppl 4): 10-12. (Pubitemid 34407461)
6. van Marrewijk CJ, Mujakovic S, Fransen GAJ, et al. Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): A primary-care-based randomised controlled trial. Lancet. 2009; 373: 215-225.
7. Talley NJ, Vakil NB, Moayyedi P. American gastroenterological association technical review on the evaluation of dyspepsia. Gastroenterology. 2005; 129: 1756-1780. (Pubitemid 41597412)
8. National Institute for Clinical Excellence. Dyspepsia: Managing dyspepsia in adults in primary care. www.nice.org.uk/nicemedia/pdf/CG017full-guideline. pdf. 2004.
9. Talley NJ, Vakil N, Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005; 100: 2324-2337.
10. Veldhuyzen van Zanten SJ, Bradette M, Chiba N, et al. Evidence-based recommendations for short- and long-term management of uninvestigated dyspepsia in primary care: an update of the Canadian Dyspepsia Working Group (CanDys) clinical management tool. Can J Gastroenterol. 2005; 19: 285-303. (Pubitemid 40812614)
11. Christie J, Shepherd NA, Codling BW, Valori RM. Gastric cancer below the age of 55: implications for screening patients with uncomplicated dyspepsia. Gut. 1997; 41: 513-517. (Pubitemid 27448784)
12. Gillen D, McColl KEL. Does concern about missing malignancy justify endoscopy in uncomplicated dyspepsia in patients aged less than 55? Am J Gastroenterol. 1999; 94: 75-79.
13. Talley NJ, Lam SK, Goh KL, Fock KM. Management guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific Working Party on functional dyspepsia. J Gastroenterol Hepatol. 1998; 13: 335-353. (Pubitemid 28215940)
14. Vakil N, Moayyedi P, Fennerty MB, Talley NJ. Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: Systematic review and meta-analysis. Gastroenterology. 2006; 131: 390-401. (Pubitemid 44142444)
15. Lucock MP, Morley S, White C, Peake MD. Responses of consecutive patients to reassurance after gastroscopy: Results of self administered questionnaire survey. BMJ. 1997; 315: 572-575. (Pubitemid 27371139)
16. Thomson ABR, Barkun AN, Armstrong D, et al. The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment - Prompt Endoscopy (CADET-PE) study. Aliment Pharmacol Ther. 2003; 17: 1481-1491. (Pubitemid 36831439)
17. Gear MWL, Barnes RJ. Endoscopic studies of dyspepsia in general practice. Br Med J. 1980; 280: 1136-1137. (Pubitemid 10110046)
18. Johnsen R, Bernersen B, Straume B, et al. Prevalence of endoscopic and histological findings in subjects with and without dyspepsia. BMJ. 1991; 302: 749-752.
19. International Agency for Research on Cancer. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 1994; 61: 1-241.
20. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on on Helicobacter pylori in Peptic Ulcer Disease. JAMA. 1994; 272: 65-69.
21. Patel P, Mendall MA, Khulusi S, et al. Prospective screening of dyspeptic patients by Helicobacter pylori serology. Lancet. 1995; 346: 1315-1318.
22. Delaney BC, Wilson S, Roalfe A, et al. Randomised controlled trial of Helicobacter pylori testing and endoscopy for dyspepsia in primary care. BMJ. 2001; 322: 898-901. (Pubitemid 32324315)
23. Duggan AE, Elliott CA, Miller P, et al. Clinical trial: A randomized trial of endoscopy, Helicobacter pylori testing and empirical therapy for the management of dyspepsia in primary care. Aliment Pharmacol Ther. 2009; 29: 55-68.
24. Bytzer P, Hansen JM, Schaffalitzky de Muckadell OB. Empirical H2-blocker therapy or prompt endoscopy in management of dyspepsia. Lancet. 1994; 343: 811-816. (Pubitemid 24147509)
25. Delaney BC, Wilson S, Roalfe A, et al. Cost effectiveness of initial endoscopy for dyspepsia in patients over age 50 years: A randomised controlled trial in primary care. Lancet. 2000; 356: 1965-1969.
26. Laheij RJF, Severens JL, Lisdonk EH, et al. Randomized controlled trial of omeprazole or endoscopy in patients with persistent dyspepsia: a cost-effectiveness analysis. Aliment Pharmacol Ther. 1998; 12: 1249-1256. (Pubitemid 28565966)
27. Lewin van den Broek NT, Numans ME, Buskens E, et al. A randomised controlled trial of four management strategies for dyspepsia: Relationships between symptom subgroups and strategy outcome. Br J Gen Pract. 2001; 51: 619-624. (Pubitemid 32725247)
28. Arents NLA, Thijs JC, van Zwet AA, et al. Approach to treatment of dyspepsia in primary care: a randomized trial comparing 'test and treat' with prompt endoscopy. Arch Intern Med. 2003; 163: 1606-1612.
29. Heaney A, Collins JSA, Watson RGP, et al. A prospective randomised trial of a "test and treat" policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic. Gut. 1999; 45: 186-190.
30. Lassen AT, Pedersen FM, Bytzer P, Schaffalitzky de Muckadell OB. Helicobacter pylori test and eradicate versus prompt endoscopy for management of dyspeptic patients: A randomised trial. Lancet. 2000; 356: 455-460. (Pubitemid 30496816)
31. McColl KEL, Murray LS, Gillen D, et al. Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H. pylori testing alone in the management of dyspepsia. BMJ 2002; 324: 999-1002. (Pubitemid 34457507)
32. Mahadeva S, Chia Y-C, Vinothini A, et al. Cost-effectiveness of and satisfaction with a Helicobacter pylori "test and treat" strategy compared with prompt endoscopy in young Asians with dyspepsia. Gut. 2008; 57: 1214-1220.
33. Lassen AT, Hallas J, Schaffalitzky de Muckadell OB. Helicobacter pylori test and eradicate versus prompt endoscopy for management of dyspeptic patients: 6.7 year follow-up of a randomised controlled trial. Gut. 2004; 53: 1758-1763. (Pubitemid 39556892)
34. Delaney BC, Qume M, Moayyedi P, et al. Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: Multi-centre randomised controlled trial (MRC-CUBE trial). BMJ. 2008; 336: 651-654.
35. Jarbol DE, Kragstrup J, Stovring H, et al. Proton pump inhibitor or testing for Helicobacter pylori as the first step for patients presenting with dyspepsia? A cluster-randomized trial. Am J Gastroenterol. 2006; 101: 1200-1208. (Pubitemid 43829982)
36. Jarbol DE, Bech M, Kragstrup J, et al. Economic evaluation of empirical antisecretory therapy versus Helicobacter pylori test for management of dyspepsia: A randomized trial in primary care. Int J Technol Assess Health Care. 2006; 22: 362-371. (Pubitemid 44469443)
37. Ford AC, Qume M, Moayyedi P, et al. Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia? An individual patient data meta-analysis. Gastroenterology. 2005; 128: 1838-1844.
38. Ford AC, Moayyedi P, Jarbol DE, et al. Meta-analysis: Helicobacter pylori "test and treat" compared with empirical acid suppression for managing dyspepsia. Aliment Pharmacol Ther. 2008; 28: 534-544.
39. Tougas G, Chen MS, Hwang P, et al. Prevalence and impact of upper gastrointestinal symptoms in the Canadian population: findings from the DIGEST study. Am J Gastroenterol. 1999; 94: 2845-2854. (Pubitemid 29482745)
40. Veldhuyzen Van Zanten SJ, Talley NJ, Bytzer P, et al. Design of treatment trials for functional gastrointestinal disorders. Gut. 1999; 45 (Suppl II) II69-II77. (Pubitemid 29434816)
41. Moayyedi P, Hunt RH, Ford AC, et al. Helicobacter pylori eradication reduces the incidence of gastric cancer: Results of a systematic review of randomized controlled trials. Gastroenterology. 2008; 134 (Suppl 1) A631-A632.