Protein autoproteolysis: Conformational strain linked to the rate of peptide cleavage by the pH dependence of the N → O acyl shift reaction

Journal of the American Chemical Society

Volumn 131, Issue 27, 2009, Pages 9475-9477

  Johansson, Denny G A ^a   Wallin, Göran ^b   Sandberg, Anders ^a   Macao, Bertil ^a   Åqvist, Johan ^b   Härd, Torleif ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC TRIAD; CHEMICAL EQUATIONS; CHEMICAL MECHANISM; CLASSICAL MECHANISM; CLEAVAGE SITES; CONFORMATIONAL ENERGIES; CONFORMATIONAL STRAINS; MODEL COMPOUND; NEUTRAL PH; NUCLEOPHILIC ATTACK; OXYANION HOLE; PEPTIDE BONDS; PEPTIDE NITROGEN; PH DEPENDENCE; QUANTUM-CHEMICAL CALCULATION; RATE ACCELERATION; SHIFT REACTIONS; SIDE CHAINS; TWISTED AMIDES; WILD TYPES;

AMIDES; AMINES; CHEMICAL ATTACK; NITROGEN; OXYGEN; PH; PROTONATION; QUANTUM CHEMISTRY; REACTION RATES; STRAIN RATE;

CONFORMATIONS;

NITROGEN; OXYGEN;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CIRCULAR DICHROISM; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT;

HYDROGEN-ION CONCENTRATION; NITROGEN; OXYGEN; PEPTIDES; PROTEIN CONFORMATION; PROTEINS; QUANTUM THEORY;

EID: 67650480533     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9010817     Document Type: Article

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