Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes

Vaccine

Volumn 27, Issue 35, 2009, Pages 4840-4849

  Valentin, Antonio ^a   Chikhlikar, Priya ^b   Patel, Vainav ^a   Rosati, Margherita ^a   Maciel, Milton ^b   Chang, Kern Hee ^b   Silvera, Peter ^c   Felber, Barbara K ^a   Pavlakis, George N ^a   August, J Thomas ^b   Marques, Ernesto T A ^b,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

CD4; CD8; Central memory; Effector memory; IFN gamma; IL 2; T cells; TNF alpha

Indexed keywords

DNA VACCINE; GAG PROTEIN; GAMMA INTERFERON; HIV 1 GAG VACCINE; LAMP GAG VACCINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA IMMUNIZATION; DNA VECTOR; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; MACACA; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ANTIBODIES; HIV-1; INJECTIONS, INTRAMUSCULAR; INTERFERON-GAMMA; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MACACA MULATTA; MALE; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 67650479218     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.05.093     Document Type: Article

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