Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: Use of a single flexible paramagnetic probe with improved estimation of its sampling space

Journal of the American Chemical Society

Volumn 131, Issue 27, 2009, Pages 9532-9537

  Bermejo, Guillermo A ^a   Strub, Marie Paule ^a   Ho, Chien ^b   Tjandra, Nico ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BINDING PROTEINS; ANGLE-SIMULATED ANNEALING; BINDING PROTEINS; CONVENTIONAL APPROACH; DATA SETS; DEGREES OF FREEDOM; DISTANCE INFORMATION; GLOBULAR DOMAINS; GLUTAMINE-BINDING PROTEINS; INTRA-DOMAIN; LIGAND-FREE; PARAMAGNETIC PROBES; PARAMAGNETIC RELAXATION ENHANCEMENTS; PROBE SAMPLING; PROTEIN BACKBONE; SAMPLING SPACE; STRUCTURE CALCULATION; X-RAY STRUCTURE;

AMINES; AMINO ACIDS; CONFORMATIONS; LIGANDS; ORGANIC ACIDS; PARAMAGNETIC MATERIALS; PARAMAGNETIC RESONANCE; PROBES; REACTION KINETICS; SPACE PROBES;

SIMULATED ANNEALING;

BINDING PROTEIN; GLUTAMINE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN STRUCTURE; X RAY;

CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR PROBE TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS;

EID: 67650469932     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902436g     Document Type: Article

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