Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension

Reproductive Sciences

Volumn 16, Issue 8, 2009, Pages 749-757

  Erkinaro, Tiina ^a   Kavasmaa, Tomi ^a   Ylikauma, Laura ^a   Mäkikallio, Kaarin ^a   Haapsamo, Mervi ^a   Acharya, Ganesh ^b   Ohtonen, Pasi ^a   Alahuhta, Seppo ^a   Räsänen, Juha ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Fetus.; Hypoxemia; Labetalol; Pindolol; Placental circulation

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; LABETALOL; NORADRENALIN; PINDOLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FETOPLACENTAL UNIT; FETUS; FETUS CIRCULATION; HEART RATE; HEMODYNAMICS; HYPOXEMIA; MATERNAL BLOOD; MATERNAL HYPERTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; PLACENTA; PLACENTA CIRCULATION; PRIORITY JOURNAL; SHEEP; STRESS; UTERUS BLOOD FLOW; VASCULAR RESISTANCE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; FETAL HYPOXIA; FETUS; HEART RATE, FETAL; HEMODYNAMICS; HYPERTENSION; LABETALOL; NOREPINEPHRINE; PINDOLOL; PLACENTA; PLACENTAL CIRCULATION; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP; UTERUS; VASCULAR RESISTANCE;

EID: 67650462850     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719109335068     Document Type: Article

References (39)

1. Magee LA Treating hypertension in women of child-bearing age and during pregnancy. Drug Saf. 2001 ; 24 (6). 457-474. (Pubitemid 32458080)
2. Frishman WH Drug therapy. Pindolol: a new beta-adrenoceptor antagonist with partial agonist activity. N Engl J Med. 1983 ; 308 (16). 940-944.
3. Westfall T., Westfall D. Adrenergic agonists and antagonists. In: Brunton LL, Lazo JS, Parker KL, eds., Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11 th ed. New York, NY: The McGraw-Hill ; 2006: 237-295.
4. MacCarthy EP, Bloomfield SS Labetalol: a review of its pharmacology, pharmacokinetics, clinical uses and adverse effects. Pharmacotherapy. 1983 ; 3 (4). 193-219.
5. Tadepalli AS, Novak PJ Intrinsic sympathomimetic activity of labetalol. J Cardiovasc Pharmacol. 1986 ; 8 (1). 44-50. (Pubitemid 16149390)
6. Feldman RL, Prida XE, Lambert CR, Hill JA Systemic and coronary hemodynamics of labetalol in normotensive patients with ischemic heart disease. Cardiovasc Drugs Ther. 1988 ; 2 (3). 355-361. (Pubitemid 18248111)
7. Thomas SH, Cooper RC, Ekwuru M., et al. Differential cardiovascular effects of propranolol, atenolol, and pindolol measured by impedance cardiography. Eur J Clin Pharmacol. 1992 ; 42 (1). 47-53.
8. Jouppila P., Kirkinen P., Koivula A., Ylikorkala O. Labetalol does not alter the placental and fetal blood flow or maternal prostanoids in pre-eclampsia. Br J Obstet Gynaecol. 1986 ; 93 (6). 543-547. (Pubitemid 16094084)
9. Jouppila P., Rasanen J. Effect of labetalol infusion on uterine and fetal hemodynamics and fetal cardiac function. Eur J Obstet Gynecol Reprod Biol. 1993 ; 51 (2). 111-117. (Pubitemid 23350388)
10. Pirhonen JP, Erkkola RU, Makinen JI, Ekblad UU Single dose of labetalol in normotensive pregnancy: effects on maternal hemodynamics and uterine and fetal flow velocity waveforms. Biol Neonate. 1991 ; 59 (4). 204-208.
11. Meizner I., Paran E., Katz M., Holcberg G., Insler V. Flow velocity analysis of umbilical and uterine artery flow in pre-eclampsia treated with propranolol or pindolol. J Clin Ultrasound. 1992 ; 20 (2). 115-119.
12. Montan S., Ingemarsson I., Marsal K., Sjoberg NO Randomised controlled trial of atenolol and pindolol in human pregnancy: effects on fetal haemodynamics. BMJ. 1992 ; 304 (6832). 946-949.
13. Rasanen J., Jouppila P. Uterine and fetal hemodynamics and fetal cardiac function after atenolol and pindolol infusion. A randomized study. Eur J Obstet Gynecol Reprod Biol. 1995 ; 62 (2). 195-201.
14. Goncalves PV, Matthes Ado C., Da Cunha SP, Lanchote VL Enantioselectivity in the steady-state pharmacokinetics and transplacental distribution of pindolol at delivery in pregnancy-induced hypertension. Chirality. 2002 ; 14 (8). 683-687. (Pubitemid 34803877)
15. Rogers BT, Sibai BM, Whybrew WD Labetalol pharmacokinetics in pregnancy-induced hypertension. Am J Obstet Gynecol. 1990 ; 162 (2). 362-366. (Pubitemid 20068497)
16. Erkinaro T., Kavasmaa T., Päkkilä M., et al. Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. Br J Anaesth. 2006 ; 96 (2). 231-237. (Pubitemid 43174665)
17. Erkinaro T., Mäkikällio K., Kavasmaa T., Alahuhta S., Rasanen J. Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. Br J Anaesth. 2004 ; 93 (6). 825-832. (Pubitemid 39585614)
18. Makikallio K., Erkinaro T., Niemi N., et al. Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model. Am J Obstet Gynecol. 2006 ; 194 (2). 542-550. (Pubitemid 43183714)
19. Eisenach JC, Mandell G., Dewan DM Maternal and fetal effects of labetalol in pregnant ewes. Anesthesiology. 1991 ; 74 (2). 292-297.
20. Bennett JW Regional body surface area of sheep. J Agric Sci. 1973 ; 81 (3). 429-432.
21. Brown H., Prescott R. Applied mixed models in medicine. 2 nd ed. West Sussex, England; John Wiley & Sons ; 2006.
22. Block BS, Schlafer DH, Wentworth RA, Kreitzer LA, Nathanielz PW Intrauterine asphyxia and the breakdown of physiologic circulatory compensation in fetal sheep. Am J Obstet Gynecol. 1990 ; 162 (5). 1325-1331. (Pubitemid 20174067)
23. Reller MD, Burson MA, Lohr JL, Morton MJ, Thornburg KL Nitric oxide is an important determinant of coronary flow at rest and during hypoxemic stress in fetal lambs. Am J Physiol. 1995 ; 269 (6 pt 2). H2074 - H2081.
24. Hooper SB, Coulter CL, Deayton JM, Harding R., Thorburn GD Fetal endocrine responses to prolonged hypoxemia in sheep. Am J Physiol. 1990 ; 259 (4 pt 2). R703 - R708.
25. Boddy K., Dawes GS, Fisher R., Pinter S., Robinson JS Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol. 1974 ; 243 (3). 599-618.
26. Paulick R., Schwab O., Kastendieck E., Wernze H. Plasma free and sulfoconjugated catecholamines during acute asphyxia in the sheep fetus-relation to cardiovascular parameters. J Perinat Med. 1988 ; 16 (2). 113-121. (Pubitemid 18186819)
27. Kjellmer I., Dagbjartsson A., Hrbek A., Karlsson K., Rosen KG Maternal beta-adrenoceptor blockade reduces fetal tolerance to asphyxia. A study in pregnant sheep. Acta Obstet Gynecol Scand Suppl. 1984 ; 118: 75-80.
28. Ferro A., Queen LR, Priest RM, et al. Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol. 1999 ; 126 (8). 1872-1880. (Pubitemid 29213107)
29. Gilbert JS, Ryan MJ, La Marca BB, Sedeek MH, Murphy SR, Granger JP Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2008 ; 294 (2). 480-485.
30. Magness RR, Rosenfeld CR Systemic and uterine responses to alpha-adrenergic stimulation in pregnant and nonpregnant ewes. Am J Obstet Gynecol. 1986 ; 155 (5). 897-904. (Pubitemid 17178353)
31. Stevens AD, Lumbers ER Effects of intravenous infusions of noradrenaline into the pregnant ewe on uterine blood flow, fetal renal function, and lung liquid flow. Can J Physiol Pharmacol. 1995 ; 73 (2). 202-208.
32. Gournay VA, Roman C., Rudolph AM Effect of beta-adrenergic stimulation on oxygen metabolism in the fetal lamb. Pediatric Research. 1999 ; 45 (3). 432-436. (Pubitemid 29157779)
33. Bodelsson G., Stjernquist M. Characterization of contractile adrenoceptors in the human umbilical artery. Eur J Pharmacol. 1995 ; 282 (1-3). 95-101.
34. Yeleswaram K., Rurak DW, Hall C., Wright MR, Axelson JE Pharmacokinetics and pharmacodynamics of labetalol in the pregnant sheep. J Pharmacol Exp Ther. 1992 ; 262 (2). 683-691.
35. Gardner DS, Fowden AL, Giussani DA Adverse intrauterine conditions diminish the fetal defense against acute hypoxia by increasing nitric oxide activity. Circulation. 2002 ; 106 (17). 2278-2283. (Pubitemid 35222225)
36. Durieux ME, Sperry RJ, Longnecker DE Effects of hypoxemia on regional blood flows during anesthesia with halothane, enflurane, or isoflurane. Anesthesiology. 1992 ; 76 (3). 402-408.
37. Brett CM, Teitel DF, Heymann MA, Rudolph AM The young lamb can increase cardiovascular performance during isoflurane anesthesia. Anesthesiology. 1989 ; 71 (5). 751-756. (Pubitemid 19275098)
38. Wei JW, Sulakhe PV Regional and subcellular distribution of beta- and alpha-adrenergic receptors in the myocardium of different species. Gen Pharmacol. 1979 ; 10 (3). 263-267. (Pubitemid 9199816)
39. Li K., Rouleau JL Alpha 1-adrenergic stimulation increases the Vmax of isolated myocardial papillary muscles. Can J Physiol Pharmacol. 1991 ; 69 (12). 1804-1809.