How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

EMBO Journal

Volumn 28, Issue 13, 2009, Pages 1953-1964

  Regni, Catherine A ^a   Roush, Rebecca F ^b   Miller, Darcie J ^a   Nourse, Amanda ^a   Walsh, Christopher T ^b   Schulman, Brenda A ^a,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Antibiotic; MccB; MccC7; Microcin; Ubiquitin activating enzyme

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; MICROCRIN C7; PROTEIN MCCB; UBIQUITIN; UNCLASSIFIED DRUG;

ADENYLATION; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ASPARTIC ACID; BACTERIOCINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; LIGASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE ALIGNMENT; UBIQUITIN-ACTIVATING ENZYMES;

BACTERIA (MICROORGANISMS); EQUIDAE; ESCHERICHIA COLI;

EID: 67650450156     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.146     Document Type: Article

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