Epoetin alfa in the critically ill: What dose? Which route?

Critical Care Medicine

Volumn 37, Issue 4, 2009, Pages 1501-1503

  Napolitano, Lena M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Anemia; Anemia of inflammation; Critically ill; Epoetin alfa; Erythropoietin; Iron deficiency

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN; IRON SACCHARATE; PLACEBO; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; BIOAVAILABILITY; BODY WEIGHT; CLINICAL TRIAL; CRITICALLY ILL PATIENT; DRUG BIOAVAILABILITY; EDITORIAL; ERYTHROCYTE TRANSFUSION; HUMAN; IRON DEFICIENCY ANEMIA; LOW DRUG DOSE; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; RETICULOCYTE; RETICULOCYTE COUNT;

ANEMIA; CRITICAL ILLNESS; EPOETIN ALFA; ERYTHROPOIETIN; HEMATINICS; HUMANS;

EID: 67650445779     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819d2d61     Document Type: Editorial

References (21)

1. Napolitano LM: Current status of blood component therapy in surgical critical care. Curr Opin Crit Care 2004; 10:311-317
2. Vincent JL, Baron JF, Reinhart K, et al: ABC (Anemia and Blood Transfusion in Critical Care) Investigators. Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
3. Corwin HL, Gettinger A, Pearl RG, et al: The CRIT study; Anemia and blood transfusion in the critically ill - Current clinical practice in the United States. Crit Care Med 2004; 32: 39-52
4. Sihler KC, Napolitano LM: Anemia of inflammation in critically ill patients. J Intensive Care Med 2008; 23:295-302
5. Corwin HL, Krantz S: Anemia in the critically ill: "acute" anemia of chronic disease. Crit Care Med 2000; 28:3098-3099
6. Weiss G, Goodnough LT: Anemia of chronic disease. N Engl J Med 2005; 352:1011-1023
7. Hobisch-Hagen P, Wiedermann F, Mayr A, et al: Blunted erythropoietic response to anemia in multiply traumatized patients. Crit Care Med 2001; 29:743-747
8. Rogiers P, Zhang H, Leeman M, et al: Erythropoeitin response is blunted in critically ill patients. Intensive Care Med 1997; 23: 159-162
9. Corwin HL, Gettinger A, Rodriguez RM, et al: Efficacy of recombinant human erythropoietin in the critically ill patient: A randomized double blind placebo controlled trial. Crit Care Med 1999; 27:2346-2350
10. Corwin HL, Gettinger A, Rodriguez RM, et al: Efficacy of recombinant human erythropoietin in the critically ill patient: A randomized double blind placebo controlled trial. JAMA 2002; 288:2827-2835
11. Corwin HL, Gettinger A, Fabian T, et al: Efficacy and safety of epoetin alpha in the critically ill. N Engl J Med 2007; 357:965-976
12. Haas CE, Forrest A: Pharmacokinetic and pharmacodynamic research in the intensive care unit: An unmet need. Crit Care Med 2006; 34:1831-1836
13. Besarab A, Reyes CM, Hornberger J: Metaanalysis of subcutaneous versus intravenous epoetin in maintenance treatment of anemia in hemodialysis patients. Am J Kidney Dis 2002; 40:439-446
14. Vincent JL, Spapen HD, Creteur J, et al: Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetin alfa in critically ill patients: Results of a randomized, double-blind, placebo-controlled trial. Crit Care Med 2006; 34:1661-1667
15. Charles A, Purtill M, Napolitano LM: Recombinant human erythropoietin in severe anaemia: Issues of dosing and duration. Anaesth Intensive Care 2006; 34:793-796
16. Ball AM, Winstead PS: Recombinant human erythropoietin therapy in critically ill Jehovah's witnesses. Pharmacotherapy 2008; 28: 1383-1390
17. Arroliga AC, Guntupalli KK, Beaver JS, et al: Pharmacokinetics and pharmacodynamics of six epoetin alfa dosing regimens in anemic critically ill patients without acute blood loss. Crit Care Med 2009; 37:1299-1307
18. Van Iperen CE, Gaillard CA, Kraaijenhagen RJ, et al: Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med 2000; 28:2773-2778
19. Pieracci FM, Barie PS: Diagnosis and management of iron-related anemias in critical illness. Crit Care Med 2006; 34:1898-1905
20. Olsson-Gisleskog P, Jacqmin P, Perez-Ruixo JJ: Population pharmacokinetics metaanalysis of recombinant human erythropoietin in healthy subjects. Clin Pharmacokinet 2007; 46:159-173
21. Napolitano LM, Fabian TC, Kelly KM, et al: Improved survival of critically ill trauma patients treated with recombinant human erythropoietin. J Trauma 2008; 65:285-297, discussion 297-299