Effect of saquinavir/ritonavir (1000/100 mg bid) on the pharmacokinetics of methadone in opiate-dependent HIV-negative patients on stable methadone maintenance therapy

Addiction Biology

Volumn 14, Issue 3, 2009, Pages 321-327

  Jamois, Candice ^b   Smith, Patrick ^a   Morrison, Royce ^c   Riek, Myriam ^b   Patel, Arpna ^a   Schmitt, Christophe ^b   Morcos, Peter N ^a   Zhang, Xiaoping ^a  

^a Department of Clinical Pharmacology ^*  (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c Northwest Kinetics   (United States)

Author keywords

Drug abusers; HIV infection; Methadone; Ritonavir; Saquinavir; Substance abuse

Indexed keywords

METHADONE; OPIATE; RITONAVIR; RITONAVIR PLUS SAQUINAVIR; SAQUINAVIR;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY HEIGHT; BODY WEIGHT; CAUCASIAN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAM; FEMALE; GASTROINTESTINAL DISEASE; GEOMETRY; GROUPS BY AGE; HUMAN; HYPERHIDROSIS; LABORATORY TEST; MALE; METHADONE TREATMENT; OPEN STUDY; OPIATE ADDICTION; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SMOKING; STEADY STATE; VITAL SIGN;

ADMINISTRATION, ORAL; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HIV PROTEASE INHIBITORS; HIV SERONEGATIVITY; HUMANS; MALE; METHADONE; MIDDLE AGED; NARCOTICS; OPIOID-RELATED DISORDERS; PROTEIN BINDING; RITONAVIR; SAQUINAVIR;

EID: 67650445586     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2009.00158.x     Document Type: Article

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