Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction

Annals of Medicine

Volumn 41, Issue 3, 2009, Pages 197-207

  Hautala, Arto J ^a,b   Tulppo, Mikko P ^a,b   Kiviniemi, Antti M ^a,b   Rankinen, Tuomo ^c   Bouchard, Claude ^c   Mkikallio, Timo H ^b,d   Huikuri, Heikki V ^b  

^a Verve   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d LAPLAND CENTRAL HOSPITAL   (Finland)

Author keywords

Acetylcholine receptor M2; Cardiac mortality; Cardiovascular autonomic regulation; Genotype; Myocardial infarction

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR; CHRM2 PROTEIN, HUMAN; MUSCARINIC M2 RECEPTOR;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CHOLINERGIC RECEPTOR M2 GENE; CONTROLLED STUDY; DNA POLYMORPHISM; EXERCISE TEST; EXON; FEMALE; FOLLOW UP; GENE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART DEATH; HEART FUNCTION; HEART RATE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; GENETIC POLYMORPHISM; GENETICS; HEART INFARCTION; MIDDLE AGED; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; PROGNOSIS;

EXERCISE TEST; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECEPTOR, MUSCARINIC M2; RISK FACTORS;

EID: 67650351368     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.1080/07853890802477866     Document Type: Article

References (32)

1. Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW, et al. Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care. 2003;26:2052-2057.
2. Nissinen SI, Makikallio TH, Seppanen T, Tapanainen JM, Salo M, Tulppo MP, et al. Heart rate recovery after exercise as a predictor of mortality among survivors of acute myocardial infarction. Am J Cardiol. 2003;91:711-714.
3. Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetiere P. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med. 2005;352:1951-1958. (Pubitemid 40638365)
4. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med. 1999;341:1351-1357.
5. Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med. 2000;132:552-555.
6. Watanabe J, Thamilarasan M, Blackstone EH, Thomas JD, Lauer MS. Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography. Circulation. 2001;104:1911-1916.
7. Vivekananthan DP, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol. 2003;42:831-838.
8. Diller GP, Dimopoulos K, Okonko D, Uebing A, Broberg CS, Babu-Narayan S, et al. Heart rate response during exercise predicts survival in adults with congenital heart disease. J Am Coll Cardiol. 2006;48:1250-1256.
9. Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev. 1999;51:651-690.
10. Caulfield MP. Muscarinic receptors*characterization, coupling and function. Pharmacol Ther. 1993;58:319-379.
11. Arai Y, Saul JP, Albrecht P, Hartley LH, Lilly LS, Cohen RJ, et al. Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol. 1989;256:H132-41.
12. Pierpont GL, Stolpman DR, Gornick CC. Heart rate recovery post-exercise as an index of parasympathetic activity. J Auton Nerv Syst. 2000;80:169-174.
13. Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol. 1994;24:1529-1535.
14. Curfman GD, Hillis LD. A new look at cardiac exercise testing. N Engl J Med. 2003;348:775-776.
15. Smith LL, Kukielka M, Billman GE. Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction. Am J Physiol Heart Circ Physiol. 2005;288:H1763-9.
16. Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J. 2004;18:711-713.
17. Hautala AJ, Rankinen T, Kiviniemi AM, Makikallio TH, Huikuri HV, Bouchard C, et al. Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism. Am J Physiol Heart Circ Physiol. 2006;291:H459-66.
18. Huikuri HV, Tapanainen JM, Lindgren K, Raatikainen P, Makikallio TH, Juhani Airaksinen KE, et al. Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. J Am Coll Cardiol. 2003;42:652-658.
19. Berning J, Steensgaard-Hansen F. Early estimation of risk by echocardiographic determination of wall motion index in an unselected population with acute myocardial infarction. Am J Cardiol. 1990;65:567-576.
20. Ruha A, Sallinen S, Nissila S. A real-time microprocessor QRS detector system with a 1-ms timing accuracy for the measurement of ambulatory HRV. IEEE Trans Biomed Eng. 1997;44:159-167.
21. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005; 15:97-98.
22. Pajunen P, Koukkunen H, Ketonen M, Jerkkola T, Immo-nen-Raiha P, Karja-Koskenkari P, et al. The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005;12:132-137.
23. Mahonen M, Salomaa V, Torppa J, Miettinen H, Pyorala K, Immonen-Raiha P, et al. The validity of the routine mortality statistics on coronary heart disease in Finland: comparison with the FINMONICA MI register data for the years 1983-1992. Finnish multinational MONItoring of trends and determinants in CArdiovascular disease. J Clin Epidemiol. 1999;52:157-166.
24. Rapola JM, Virtamo J, Korhonen P, Haapakoski J, Hartman AM, Edwards BK, et al. Validity of diagnoses of major coronary events in national registers of hospital diagnoses and deaths in Finland. Eur J Epidemiol. 1997;13:133-138.
25. Padley JR, Overstreet DH, Pilowsky PM, Goodchild AK. Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity. Am J Physiol Heart Circ Physiol. 2005;289:H1985-92.
26. Colucci WS, Ribeiro JP, Rocco MB, Quigg RJ, Creager MA, Marsh JD, et al. Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. Circulation. 1989;80:314-323.
27. Izawa K, Tanabe K, Omiya K, Yamada S, Yokoyama Y, Ishiguro T, et al. Impaired chronotropic response to exercise in acute myocardial infarction patients with type 2 diabetes mellitus. Jpn Heart J. 2003;44:187-199. (Pubitemid 41519018)
28. Binkley PF, Nunziata E, Haas GJ, Nelson SD, Cody RJ. Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model of ventricular failure. J Am Coll Cardiol. 1991;18: 464-472.
29. Makikallio TH, Barthel P, Schneider R, Bauer A, Tapanainen JM, Tulppo MP, et al. Frequency of sudden cardiac death among acute myocardial infarction survivors with optimized medical and revascularization therapy. Am J Cardiol. 2006;97:480-484.
30. Gibbons RJ. Abnormal heart-rate recovery after exercise. Lancet. 2002;359:1536-1537.
31. Wolk R, Somers VK, Gibbons RJ, Olson T, O?Malley K, Johnson BD. Pathophysiological characteristics of heart rate recovery in heart failure. Med Sci Sports Exerc. 2006;38: 1367-1373.
32. Arena R, Guazzi M, Myers J, Peberdy MA. Prognostic value of heart rate recovery in patients with heart failure. Am Heart J. 2006;151:851.e7-13pp