Percutaneous absorption of an insect repellent P-menthane-3,8-diol: A model for human dermal absorption

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 13, 2009, Pages 796-806

  Reifenrath, William G ^a   Olson, James J ^b   Vedula, Usha ^b   Osimitz, Thomas G ^c  

^a Stratacor Inc   (United States)

^b S C Johnson & Son Inc   (United States)

^c Science Strategies LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLTOLUAMIDE; DRUG DERIVATIVE; INSECT REPELLENT; MENTHOL; PIPERONYL BUTOXIDE; TERPIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; POSTMARKETING SURVEILLANCE; RAT; SKIN; SKIN ABSORPTION; SPRAGUE DAWLEY RAT; SWINE;

ANIMALS; DEET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INSECT REPELLENTS; MALE; MENTHOL; MOLECULAR STRUCTURE; PIPERONYL BUTOXIDE; PRODUCT SURVEILLANCE, POSTMARKETING; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SWINE;

EID: 67650327613     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390902800371     Document Type: Article

References (36)

1. Anonymous. 1981. ANSI/ASHRAE Standard 55-1981, Thermal environmental conditions for human occupancy. http://www.ashrae.org/technology/page/548.
2. Anonymous. 1998. Reregistration eligibility decision for DEET. EPA 738-R-98-010. http://www.epa.gov/oppsrrd1/REDs//0002red.pdf.
3. Anonymous. 2000. p-Menthane-3,8-diol biopesticide registration eligibility document, US EPA. http://www.epa.gov/oppbppd1/biopesticides/ ingredients/tech-docs/tech-011550.htm.
4. Anonymous. 2004. Guidance document for the conduct of skin absorption studies. Paris: Organization for Economic Cooperation and Development.
5. Anonymous. 2006. Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients. Scientific Committee on Consumer Products, European Commission. http://ec.europa.eu/health/ph-risk/committees/04-sccp-s-03. pdf
6. Anonymous. 2008. Technical data sheet for permethyl (isododcane). Special-Chem Cosmetics. http://www.specialchem4cosmetics.com
7. Boomsma, J. C., and Parathasarathy, M. 1990. Human use and exposure to insect repellents containing DEET. Department of Pesticide Reg. Doc. No. 50191:162. U.S. Environmental Protection Agency, Washington, D.C.
8. Feldmann, R. J., and Maibach, H. I. 1970. Absorption of some organic compounds through the skin in man. J. Invest. Dermatol. 54:399-404.
9. Hansch, C., Leo, A., and Hoekman, D. 1995. Exploring QSAR hydrophobic, electronic and steric constants. ACS professional reference book, pp. 49 and 165. Washington, DC: American Chemical Society.
10. Hawkins, G. S. 1990. Methodology for the execution of in vitro skin penetration determinations. In Methods for skin absorption, eds. B. W. Kemppainen and W. G. Reifenrath, pp. 67-80. Boca Raton, FL: CRC Press.
11. Hawkins, G. S., and Reifenrath, W. G. 1984. Development of an in vitro model for determining the fate of chemicals applied to skin. Fundam. Appl. Toxicol. 4:S133-S144.
12. Hawkins, G. S., and Reifenrath, W. G. 1986. The influence of skin source, penetration cell fluid and partition coefficient on in vitro skin penetration. J. Pharm. Sci. 75:378-381.
13. Kemppainen, B. W., Reifenrath, W. G., Stafford, R. G., and Mehta, M. 1991. Methods for in vitro skin absorption studies of a lipophilic toxin produced by red tide. Toxicology 66:1-17.
14. Klain, G. J. Reifenrath, W. G., and Black, K. E. 1985. Distribution and metabolism of topicaly applied ethanolamine. Fundam. Appl. Toxicol. 5:S127-S133.
15. Moody, R. P., Benoit, F. M. Rieder, D., and Ritter, L. 1989. Dermal absorption of the insect repellent DEET (N,N-diethyl-m-toluamide) in rats and monkeys: Effect of anatomical site and multiple exposure. J. Toxicol. Environ. Health 26:137-147.
16. Qui, H., Jun, H. W., and McCall, J. W. 1998. Pharmacokinetics, formulation, and safety of insect repellent N,N-diethyl-3-methylbenzamide (DEET): A review. J. Am. Mosquito Control Assoc. 14:12-27.
17. Ramsey, J. D., Woollen, B. H., Auton, T. R., Batten, P. L., and Lesser, J. E. 1992. Pharmacokinetics of fluazifop-butyl in human volunteers. II. Dermal dosing. Hum. Exp. Toxicol. 4:247-254.
18. Reifenrath, W.G. 1995. Volatile substances. Cosmet. Toilet. 110:85-92.
19. Reifenrath, W. G. 2007. Enhanced skin absorption and fly toxicity of permethrin in emulsion formulation. Bull. Environ. Contamin. Toxicol. 78:299-303.
20. Reifenrath, W. G., and Hawkins, G. S. 1986. The weanling Yorkshire pig as an animal model for measuring percutaneous penetration. In Swine in biomedical research, ed. M. E. Tumbleson, pp. 673-680. New York: Plenum.
21. Reifenrath, W. G. and Kemppainen, B. W. 1991. Skin storage conditions. In In vitro percutaneous absorption: Principles, fundamentals, and applications, eds. R. L. Bronaugh and H. I. Maibach, pp. 115-127. Boca Raton, FL: CRC Press.
22. Reifenrath, W. G., Robinson, P. B., Bolton, V. D., and Aliff, R. W. 1981. Percutaneous penetration of mosquito repellents in the hairless dog: Effect of dose on percentage penetration. Food Cosmet. Toxicol. 19:195-199.
23. Reifenrath, W. G., and Robinson, P. B. 1982. In vitro skin evaporation and penetration characteristics of mosquito repellents. J. Pharm. Sci. 71:1014-1018.
24. Reifenrath, W. G., Chellquist, E. M., Shipwash, E. A., Jederberg, W. W., and Krueger, G. G. 1984. Percutaneous penetration in the hairless dog, weanling pig and grafted athymic nude mouse: Evaluation of model for predicting skin penetration in man. Br. J. Dermatol. 3(Suppl.):27:123-135.
25. Reifenrath, W. G., Hawkins, G. S., and Kurtz, M. S. 1989. Evaporation and skin penetration characteristics of mosquito repellent formulations. J. Am. Mosquito Control Assoc. 5:45-51.
26. Reifenrath, W. G., Lee, B., Wilson, D. R., and Spencer, T. S. 1994. A comparison of in vitro skin-penetration cells. J. Pharm. Sci. 83:1229-1233.
27. Reifenrath, W. G., Kammen, H. O., Palmer, W. G., Major, M. M. and Leach, G. J. 2002. Percutaneous absorption of explosives and related compounds: An empirical model of bioavailability of organic nitro compounds from soil. Toxicol. Appl. Pharmacol. 182:160-168.
28. Reifenrath, W. G. Garzouzi, V. L., and Kammen, H. O. 2004. Use of pig skin preparations in novel diffusion cell arrays to measure skin absorption and to evaluate potential chemical toxicity. In Dermatotoxicology, 6th ed., eds. H. Zhai and HI Maibach, pp. 901-935. Boca Raton, FL: CRC Press.
29. Schackleford, J. M., Yielding, L., and Scherff, A. H. 1984. Observations of epidermal exsorption in mice following injections of procion dyes and ethidium bromide and topically applied dimethyl sulfoxide. J. Invest. Dermatol. 82:629-631.
30. Selim, S., Hartnagel, R. E., Osimitz, T. G., Gabriel, K. L., and Schoenig, G. P. 1995. Absorption, metabolism, and excretion of N,N-diethyl-m-toluamide following dermal application to human volunteers. Fundam. Appl. Toxicol. 25:95-100.
31. Selim, S. Preiss, F. J., Gabriel, K. L., Jonkman, J. H., and Osimitz, T. G. 1999. Absorption and mass balance of piperonyl butoxide following an 8-h dermal exposure in human volunteers. Toxicol. Lett. 107:207-217.
32. Shah, P. V., Fisher, H. L., Sumler, M. R., Monroe, R. J., Chernoff, N., and Hall, L. L. 1987. Comparison of the penetration of 14 pesticides through the skin of young and adult rats. J. Toxicol. Environ. Health 21:353-366.
33. Smith, K. L. 1990. Penetration characteristics influencing skin absorption. In Methods for skin absorption, eds. B. W. Kemppainen and W. G. Reifenrath, pp. 23-34. Boca Raton, FL: CRC Press.
34. Sudakin, D. L., and Trevathan, W. R. 2003. DEET: A review and update of safety and risk in the general population. Clin. Toxicol. 41:831-839.
35. Taylor, W. G., Danielson, T. J., Spooner, R. W., and Golsteyn, L. R. 1994. Pharmacokinetic assessment of the dermal absorption of N,N-diethyl-mtoluamide (DEET) in cattle. Drug Metab. Dispos. 22:106-112.
36. Wester, R. C., Bucks, D. A., and Maibach, H. I. 1994. Human in vivo percutaneous absorption of pyrethrin and piperonyl butoxide. Food Chem. Toxicol. 32:51-53.