Is continuous treatment with transforming growth factor-beta necessary to induce chondrogenic differentiation in mesenchymal stem cells?

Cells Tissues Organs

Volumn 190, Issue 1, 2009, Pages 1-10

  Kim, Hye Joung ^a   Kim, Young Ju ^a   Im, Gun Il ^a  

^a Dongguk University Ilsan Hospital   (South Korea)

Author keywords

Cartilage; Cell differentiation; Chondrogenesis; Growth factors; Mesenchymal stem cells

Indexed keywords

COLLAGEN TYPE 10; COLLAGEN TYPE 2; DNA; GAG PROTEIN; GLYCOSAMINOGLYCAN; PROCOLLAGEN; PROCOLLAGEN B TYPE 2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CHONDROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; DNA; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLYCOSAMINOGLYCANS; HUMANS; MESENCHYMAL STEM CELLS; MIDDLE AGED; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAINING AND LABELING; TRANSFORMING GROWTH FACTOR BETA;

EID: 67650314504     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000153041     Document Type: Article

References (36)

1. Attisano, L., J.L. Wrana (2002) Signal transduc-tion by the TGF-beta superfamily. Science 296: 1646 -1647.
2. Barry, F., R.E. Boynton, B. Liu, J.M. Murphy (2001) Chondrogenic differentiation of mes-enchymal stem cells from bone marrow; differentiation-dependent gene expression of matrix components. Exp Cell Res 268: 189- 200.
3. Benya, P.D., S.R. Padilla, M.E. Nimni (1978) Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture. Cell 15: 1312-1313.
4. Brittberg, M., A. Lindahl, A. Nilsson, C. Ohls-son, O. Isaksson, L. Peterson (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 333: 889-895.
5. Buckwalter, J.A., H.J. Mankin (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47: 487-504.
6. Caplan, A.I. (1991) Mesenchymal stem cells. J Orthop Res 9: 641- 650.
7. Daniel, G.A., S.S. Sheila, M. Ryhanna, W.P. Donald, E.S. Robert (1995) Repair of articular cartilage defects using mesenchymal stem cells. Tissue Eng 1: 1345-1353.
8. Dennis, J.E., J.P. Carbillet, A.I. Caplan, P. Char-bord (2002) The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs 170: 73-82.
9. Fortier, L.A., A.J. Nixon, J. Williams, C.S. Cable (1998) Isolation and chondrocytic differentiation of equine bone marrow-derived mes-enchymal stem cells. Am J Vet Res 59: 1182- 1187.
10. Ghazavi, M.T., K.P. Pritzker, A.M. Davis, A.E. Gross (1997) Fresh osteochondral allografts for post-traumatic osteochondral defects of the knee. J Bone Joint Surg Br 79: 1008- 1013.
11. Grogan, S.P., A. Barbero, V. Winkelmann, F. Rieser F, J.S. Fitzsimmons, S. O'Driscoll, I. Martin, P. Mainil-Varlet (2006) Visual histo-logical grading system for the evaluation of in vitro-generated neocartilage. Tissue Eng 12: 2141-2149.
12. Hering, T.M., N.H. Kazmi, T.D. Huynh, J. Kollar, L. Xu (2004) Characterization and chondro-cyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470. Exp Cell Res 299: 137-147.
13. Im, G.I., N.H. Jung, S.K. Tae (2006) Chondro-genic differentiation of mesenchymal stem cel ls isolated from pat ients in late adult hood: the optimal conditions of growth factors. Tissue Eng 12: 527-536.
14. Im, G.I., D.Y. Kim, J.H. Shin, C.W. Hyun, W.H. Cho (2001) Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow. J Bone Joint Surg 83: 289-294.
15. Im, G.I., Y.W. Shin, K.B. Lee (2005) Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteo-arthritis Car tilage 13: 845-853.
16. Indrawattana, N., G. Chen, M. Tadokoro, L.H. Shann, H. Ohgushi, T. Tateishi, J. Tanaka, A. Bunyaratvej (2004) Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Bio-phys Res Commun 30: 914 - 920.
17. Iwasaki, M., K. Nakata, H. Nakahara, T. Nakase, T. Kimura, K. Kimata, A.I. Caplan, K. Ono (1993) Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits os-teogenesis in high density culture of periosteum-derived cells. Endocrinology 132: 1603 -1608.
18. Johnstone, B., T.M. Hering, A.I. Caplan, V.M. Goldberg, J.U. Yoo (1998) In vitro chondro-genesis of bone marrow-derived mesenchy-mal progenitor cells. Exp Cell Res 238: 265- 272.
19. Kerol, B., B. Stepan, B. Birgit (2005) Clon-al heterogeneity in growth kinetics of CD34+CD38- human cord blood cells in vi-tro is correlated with gene expression pattern and telomere length. Stem Cells 23: 946- 957.
20. Kuznetsov, S.A., A.J. Friedenstein, P.G. Robey (1997) Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol 97: 561-570.
21. Lefebvre, V. , C. Peeters-Joris, G. Vae s (1990) Production of collagens, collagenase and colla-genase inhibitor during the dedifferentia-tion of articular chondrocytes by serial subcultures. Biochim Biophys Acta 1051: 266-275.
22. Leonard, C.M., H.M. Fuld, D.A. Frenz, S.A. Downie, J. Massague, S.A. Newman (1991) Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenous TGF-beta and evidence for endogenous TGF-beta-like activity. Dev Biol 145: 99-109.
23. Mackay, A.M., S.C. Beck, J.M. Murphy, F.P. Barry, C.O. Chichester, M.F. Pittenger (1998) Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng 4: 415-428.
24. Massague, J., R. Gomis (2006) The logic of TGF-beta signaling. FEBS Lett 580: 2811-2820.
25. Mehlhorn, A.T., P. Niemeyer, S. Kaiser, G. Finkenzeller, G.B. Stark, N.P. Sudkamp, H. Schmal (2006a) Differential expression pattern of extracellular matrix molecules during chondrogenesis of mesenchymal stem cells from bone marrow and adipose tissue. Tissue Eng 12: 2853-2862.
26. Mehlhorn, A.T., H. Schmal, S. Kaiser, G. Lepski, G. Finkenzeller, G.B. Stark, N.P. Sudkamp (2006b) Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic pheno-type in alginate bead culture. Tissue Eng 12: 1393-1403.
27. Meyers, M.H., W. Akeson, F.R. Convery (1989) Resurfacing of the knee with fresh osteo-chondral allograft. J Bone Joint Surg 71: 704 - 713.
28. Miura, Y., J.S. Fitzsimmons, C.N. Commisso, S.H. Gallay, S.W. O'Driscoll (1994) Enhancement of periosteal chondrogenesis in vitro. Dose-response for transforming growth factor-beta 1 (TGF-beta 1). Clin Orthop Relat Res 301: 271-280.
29. Miura, Y., J. Parvizi, J.S. Fitzsimmons, S.W. O'Driscoll (2002) Brief exposure to high-dose transforming growth factor-beta 1 enhances periosteal chondrogenesis in vitro: a preliminary report. J Bone Joint Surg Am 84: 793-799.
30. Pelttari, K., A. Winter, E. Steck, K. Goetzke, T. Hennig, B.G. Ochs, T. Aigner, W. Richter (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54: 3254-3266.
31. Pittenger, M.F., A.M. Mackay, S.C. Beck, R.K. Jaiswa l, F. Douglas, J.D. Mosea (1999) Multi-lineage potential of adult human mesenchy-mal stem cells. Science 284: 14 3 -14 7.
32. Rosen, D.M., S.A. Stempien, A.Y. Thompson, S.M. Seyedin (1988) Transforming growth factor-beta modulates the expression of os-teoblast and chondroblast phenotypes in vitro. J Cell Physiol 134: 337-346.
33. Vats, A., R.C. Bielby, N. Tolley, S.C. Dickinson, A.R. Boccaccini, A.P. Hollander, A.E. Bishop, J.M. Polak (2006) Chondrogenic differentiation of human embryonic stem cells: the effect of the micro-environment. Tissue Eng 12: 1687-1697.
34. Wakitani, S., T. Goto, S.J. Pineda, R.G. Young, J.M. Mansour, A. I. Caplan (1994) Mesenchy-mal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg 76: 579-592.
35. Worster, A.A., B.D. Brower-Toland, L.A. Fortier, S.J. Bent, J. Williams, A.J. Nixon (2001) Chondrocytic differentiation of mesenchy-mal stem cells sequentially exposed to transforming growth factor-beta 1 in monolayer and insulin-like growth factor-I in a three dimensional matrix. J Orthop Res 19: 738- 749.
36. Worster, A.A., A.J. Nixon, B.D. Brower-Toland, J. Williams (2000) Effect of transforming grow th fac tor beta 1 on chond rogenic differ-entiation of cultured equine mesenchymal stem cells. Am J Vet Res 61: 1003-1010.