Bilateral vagotomy inhibits apnea and attenuates other physiological responses after blunt chest trauma

Journal of Trauma - Injury, Infection and Critical Care

Volumn 64, Issue 6, 2008, Pages 1420-1426

  Gryth, Dan ^a   Rocksén, David ^a,d   Arborelius, Ulf P ^a   Drobin, Dan ^a   Persson, Jonas K E ^a,c   Sondén, Anders ^a,b   Bursell, Jenny ^a   Olsson, Lars Gunnar ^a   Kjellström, B Thomas ^a,b  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apnea; Behind armor blunt trauma; Electroencephalogram; Vagotomy

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APNEA; ARTICLE; ASSISTED VENTILATION; BODY ARMOR; BRAIN FUNCTION; BREATHING RATE; BREATHING REFLEX; CADAVER; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DISEASE DURATION; EEG ABNORMALITY; FEMALE; GUNSHOT INJURY; HEART RATE; HYPOXIA; LUNG ARTERY PRESSURE; LUNG CONTUSION; LUNG MINUTE VOLUME; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OUTCOME ASSESSMENT; OXYGEN SATURATION; PRIORITY JOURNAL; SWINE; THORAX BLUNT TRAUMA; TIDAL VOLUME; VAGOTOMY; ANIMAL; BALLISTICS; BLUNT TRAUMA; BRADYCARDIA; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; HYPOTENSION; PROBABILITY; RANDOMIZATION; REFERENCE VALUE; RESPIRATORY FAILURE; RISK ASSESSMENT; SURVIVAL RATE; THORAX INJURY; TRAUMATIC SHOCK;

ANIMALS; APNEA; BRADYCARDIA; CONFIDENCE INTERVALS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; FORENSIC BALLISTICS; HYPOTENSION; PROBABILITY; RANDOM ALLOCATION; REFERENCE VALUES; RESPIRATORY INSUFFICIENCY; RISK ASSESSMENT; SHOCK, TRAUMATIC; SURVIVAL RATE; SWINE; THORACIC INJURIES; WOUNDS, NONPENETRATING;

EID: 67650305366     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318054e247     Document Type: Article

References (35)

1. Carroll AW, Soderstrom CA. A new nonpenetrating ballistic injury. Ann Surg. 1978;188:753-757.
2. Cooper GJ, Taylor DE. Biophysics of impact injury to the chest and abdomen. J R Army Med Corps. 1989;135:58-67.
3. Cannon L. Behind armour blunt trauma - an emerging problem. J R Army Med Corps. 2001;147:87-96.
4. Grimal Q, Naili S, Watzky A. A high-frequency lung injury mechanism in blunt thoracic impact. J Biomech. 2005;38:1247-1254.
5. Roberts JC, O'Connor JV, Ward EE. Modeling the effect of non-penetrating ballistic impact as a means of detecting behind armor blunt trauma. J Trauma. 2005;58:1241-1251.
6. Moseley RV, Vernick JJ, Doty DB. Response to blunt chest injury: a new experimental model. J Trauma. 1970;10:673-683.
7. Sarron J, Destombe C, Lonjon T, Cuncha J, Vassout P, Magnan P. Review of behind armor blunt trauma studies since 1999. In: RTO AVT/HFM Specialist' Meeting on "Equipment for Personal Protection (AVT-097)" and "Personal Protection: Bio-Mechanical Issue and Associated Physio-Pathological Risks (HFM-102)"; May 19-23, 2003; Koblenz, Germany; 2003. p. 1-14.
8. Drobin D, Gryth DA, Persson JK, et al. EEG-changes, circulation and lung function after high velocity behind armor blunt trauma (BABT). J Trauma. 2007;63:405-413.
9. Irwin RJ, Lerner MR, Bealer JF, Mantor C, Brackett DJ, Tuggle DW. Shock after blast wave injury is caused by a vagally mediated reflex. J Trauma. 1999;47:105-110.
10. Mayorga MA. The pathology of primary blast overpressure injury. Toxicology. 1997;121:17-28.
11. Guy RJ, Kirkman E, Watkins PE, Cooper GJ. Physiologic responses to primary blast. J Trauma. 1998;45:983-987.
12. Ohnishi M, Kirkman E, Guy RJ, Watkins PE. Reflex nature of the cardiorespiratory response to primary thoracic blast injury in the anaesthetised rat. Exp Physiol. 2001;86:357-364.
13. Singer P, Cohen JD, Stein M. Conventional terrorism and critical care. Crit Care Med. 2005;33(1 Suppl):S61-S65.
14. Coleridge JC, Coleridge HM. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol. 1984;99:1-110.
15. Prehospital Trauma Life Support Committee of The National Association of Emergency Medical Technicians in Cooperation with The Committee on Trauma of The American College of Surgeons. Prehospital Trauma Life Support. Basic and Advanced. St. Louis, MO: Mosby, Inc.; 1999.
16. Thews G. Pulmonary respiration. In: Schmidt RF, Thews G, eds. Human Physiology. Berlin, Germany: Springer-Verlag; 1983: 480-488.
17. Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol. 2001;125:47-65.
18. Rutecki P. Anatomical, physiological, and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia. 1990;31 (Suppl 2):S1-S6.
19. Roberts AM, Bhattacharya J, Schultz HD, Coleridge HM, Coleridge JC. Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs. Circ Res. 1986;58:512-522.
20. Adams L, Schneider DA, Schertel ER, Strong EB, Green JF. Respiratory reflexes in the anesthetized miniature swine. Respir Physiol. 1987;70:343-357.
21. Harris MB, St-John WM. Tonic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation. Am J Physiol Regul Integr Comp Physiol. 2003;285:R215-R221.
22. Jaffin JH, McKinney L, Kinney RC, et al. A laboratory model for studying blast overpressure injury. J Trauma. 1987;27:349-356.
23. Pickar JG, Hill JM, Kaufman MP. Stimulation of vagal afferents inhibits locomotion in mesencephalic cats. J Appl Physiol. 1993; 74:103-110.
24. DiCarlo SE, Collins HL, Chen CY. Vagal afferents reflexly inhibit exercise in conscious rats. Med Sci Sports Exerc. 1994;26:459-462.
25. Irwin RJ, Lerner MR, Bealer JF, Brackett DJ, Tuggle DW. Cardiopulmonary physiology of primary blast injury. J Trauma. 1997;43:650-655.
26. Clemedson CJ. Blast injury. Physiol Rev. 1956;36:336-354.
27. Clemedson CJ, Pettersson H. Genesis of respiratory and circulatory changes in blast injury. Am J Physiol. 1953;174:316-320.
28. Daly MD, Kirkman E. Cardiovascular responses to stimulation of pulmonary C fibres in the cat: their modulation by changes in respiration. J Physiol. 1988;402:43-63.
29. Clement MG, Albertini M, Dimori M, Aguggin G. PAF and the role of the vagus nerve in the breathing pattern of the pig. Prostaglandins Leukot Essent Fatty Acids. 1992;45:143-149.
30. Cernak I, Savic J, Malicevic Z, et al. Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma. 1996;40(3 Suppl):S100-S104.
31. Balzamo E, Jammes Y. Vagal afferents and EEG rhythms in the Sl area in anesthetized cats: similarities between responses to electrical and chemical (phenyldiguanide) stimulations. Arch Int Physiol Biochim. 1989;97:483-492.
32. Balzamo E, Gayan-Ramirez G, Jammes Y. Pulmonary vagal sensory afferents and spontaneous EEG rhythms in the cat sensorimotor cortex. J Auton Nerv Syst. 1990;30:149-157.
33. Axelsson H, Hjelmqvist H, Medin A, Persson JK, Suneson A. Physiological changes in pigs exposed to a blast wave from a detonating high-explosive charge. Mil Med. 2000;165:119-126.
34. Young MW. War Medicine. The American Medical Association; 1945.
35. Clemedson CJ. Shock wave transmission to the central nervous system. Acta Physiol Scand. 1956;37:204-214.