Identification and functional characterization of protein kinase A-catalyzed phosphorylation of potassium channel Kv1.2 at serine 449

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16562-16574

  Johnson, Rosalyn P ^a   El Yazbi, Ahmed ^a   Hughes, Morgan F ^a   Schriemer, David C ^a   Walsh, Emma J ^a   Walsh, Michael P ^a   Cole, William C ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8-BR-CAMP; CATALYTIC SUBUNITS; CHANNEL MODULATION; CURRENT AMPLITUDE; DELAYED RECTIFIER; DOUBLE MUTANTS; ELECTRO-PHYSIOLOGICAL METHODS; FUNCTIONAL CHARACTERIZATION; HEK293 CELLS; IN-SITU; IN-VITRO; MALDI TOF MS; MALDI-TOF; MASS SPECTROSCOPY; MATRIX-ASSISTED LASER DESORPTION IONIZATION; MEMBRANE POTENTIALS; MOLECULAR BASIS; MOLECULAR MECHANISM; MULTIPLE REACTION MONITORING; PHOSPHOPEPTIDE; PHOSPHORYLATION SITES; POTASSIUM CHANNELS; PROTEIN KINASE A; SERINE RESIDUES; SMOOTH MUSCLES; TIME OF FLIGHT; VASCULAR SMOOTH MUSCLES; WILD TYPES;

AMINES; AMINO ACIDS; DESORPTION; DIALYSIS; FETAL MONITORING; MASS SPECTROMETRY; MUSCLE; POTASSIUM;

PHOSPHORYLATION;

CYCLIC AMP DEPENDENT PROTEIN KINASE; DELAYED RECTIFIER POTASSIUM CHANNEL; PHOSPHOPEPTIDE; POTASSIUM CHANNEL KV1.2; SERINE; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MODULATION; MOLECULAR DYNAMICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; STOICHIOMETRY; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; KIDNEY; KV1.2 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RABBITS; SERINE;

EID: 67650273028     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.010918     Document Type: Article

References (39)

1. Nelson, M. T., and Quayle, J. M. (1995) Am J. Physiol. 268, C799-C822
2. Knot, H. J., and Nelson, M. T. (17995) Am. J. Physiol. 269, H348-H355
3. Davis, M. J., and Hill, M. A. (1999) Physiol. Rev. 79, 387-423
4. Kerr, P. M., Clément-Chomienne, O., Thorneloe, K. S., Chen, T. T., Ishii, K., Sontag, D. P., Walsh, M. P., and Cole, W. C. (2001) Circ. Res. 89, 1038-10441
5. Thorneloe, K. S., Chen, T. T., Kerr, P. M., Grier, E. F., Horowitz, B., Cole, W. C., and Walsh, M. P. (2001) Circ. Res. 89, 1030-1037
6. Albarwani, S., Nemetz, L. T., Madden, J. A., Tobin, A. A., England, S. K., Pratt, P. F., and Rusch, N. J. (2003) J. Physiol. 551, 751-763
7. Plane, F., Johnson, R., Kerr, P., Wiehler, W., Thorneloe, K., Ishii, K., Chen, T., and Cole, W. (2005) Circ. Res. 96, 216-224
8. Hayabuchi, Y., Standen, N. B., and Davies, N. W. (2001) Am. J. Physiol. Heart Circ. Physiol. 281, H2480-2489
9. Luykenaar, K. D., Brett, S. E., Wu, B. N., Wiehler, W. B., and Welsh.D. G. (2004) Am. J. Physiol. Heart Circ. Physiol. 286, H1088-1100
10. Aiello, E. A., Walsh, M. P., and Cole, W. C. (1995) Am. J. Physiol. 268, H926-H934
11. Aiello, E. A., Clément-Chomienne, O., Sontag, D. P., Walsh, M. P., and Cole, W. C. (1996) Am. J. Physiol. 271, H109-H119
12. Aiello, E. A., Malcolm, A. T., Walsh, M. P., and Cole, W. C. (1998) Am. J. Physiol. 275, H448-H459
13. Cole, W. C., Clément-Chomienne, O., and Aiello, E. A. (1996) Biochem. Cell Biol. 74, 439-447
14. Dong, H., Waldron, G. J., Cole, W. C., and Triggle, C. R. (1998) Br. J. Pharmacol. 123, 821-832
15. Satake, N., Shibata, M., and Shibata, S. (1996) Br. J. Pharmacol. 119, 505-510
16. Li, H., Chai, Q., Gutterman, D. D., and Liu, Y. (2003) Am. J. Physiol. Heart Circ. Physiol. 285, H1213-1219
17. Heaps, C. L., and Bowles, D. K. (2002) J. Appl. Physiol. 92, 550-558
18. Heaps, C. L., Tharp, D. L., and Bowles, D. K. (2005) Am. J. Physiol. Heart Circ. Physiol. 288 H568-576
19. Berg, T. (2003) Eur. J. Pharmacol. 466 30l-310
20. Du, C., Carl, A., Smith, T. K., Sanders, K. M., and Keef, K. D. (1994) J. Pharmacol. Exp. Ther. 268, 208-215
21. Koh, S. D., Sanders, K. M., and Carl, A. (1996) Pflugers Arch. 432, 401-412
22. Shuttleworth, C. W., Koh, S. D., Bayginov, O., and Sanders, K. M. (1996) J. Physiol. 493, 651-663
23. Huang, X. Y., Morielli, A. D., and Peralta, E. G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 624-628
24. Kennelly, P. J., and Krebs, E. G. (1991) J. Biol. Chem. 266, 15555-15558
25. Minor, D. L., Lin, Y. F., Mobley, B. C., Avelar, A., Jan, Y. N., Jan, L. Y., and Berger, J. M. (2000) Cell 102, 657-670
26. Yang, J. W., Vacher, H., Park, K. S., Clark, E., and Trimmer, J. S. (2007) Proc. Natl. Acad Sci. U. S. A. 104, 20055-20060
27. Connors, E. C., Ballif, B. A., and Morielli, A. D. (2008) J. Biol. Chem. 283, 3445-3453
28. Chen, T. T., Luykenaar, K. D., Walsh, E. J., Walsh, M. P., and Cole, W. C. (2006) Circ. Res. 99, 53-60
29. Xiao, B., Jiang, M. T., Zhao, M., Yang, D., Sutherland, C., Lai, F. A., Walsh, M. P., Warltier, D. C., Cheng, H., and Chen, S. R. (2005) Circ. Res. 96, 847-855
30. Colburn, J. C., Michnoff, C. H., Hsu, L. C., Slaughter, C. A., Kamm, K. E., and Stull, J. T. (1988) J. Biol. Chem. 263, 19166-19173
31. Boyle, W. J., van der Geer, P., and Hunter, T. (1991) Methods Enzymol. 201, 110-149
32. Erickson, A. C., and Johnson, G. V. (1993) J. Neurosci. Methods 46, 245-249
33. Allen, B. G., Andrea, J. E., and Walsh, P., (1994) J. Biol. Chem. 269, 29288-29298
34. Demaille, J. G. Peters, K. A., Strandjord, T. P., and Fischer, E, H. (1978) FEBS Lett. 86, 113-116
35. Unwin, R. D., Griffiths, J. R., Leverentz, M. K., Grallert, A., Hagan, I. M., and Whetton, A. D. (2005) Mol. Cell Proteomics 4, 1134-1144
36. Anderson, A. E., Adams, J. P., Qian, Y., Cook, R. G., Pfaffinger, P. J., and Sweatt, J. D. (2000) J. Biol. Chem. 275, 5337-5346
37. Ju, M., Stevens, L., Leadbitter, E., and Wray, D. (2003) J. Biol. Chem 278 12769-12778
38. VanDongen, A. M., Frech, G. C., Drewe, J. A., Joho, R. H., and Brown, A. M. (1990) Neuron 5, 433-443
39. Zhao, L. L., Wu, A., Bi, L. J., Liu, P., Zhang, X. E., Jiang, T., Jin, G., and Qi, Z. (2009) Mol. Memb. Biol. 26, 186-193