L-dopa medication in Parkinson's disease restores activity in the motor cortico-striatal loop but does not modify the cognitive network

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Jubault, Thomas ^a,b   Monetta, Laura ^a,b   Strafella, Antonio P ^c   Lafontaine, Anne Louise ^d   Monchi, Oury ^a,b  

^a CENTRE DE RECHERCHE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c TORONTO WESTERN HOSPITAL   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LEVODOPA;

ADULT; AGED; ARTICLE; BRAIN FUNCTION; CAUDATE NUCLEUS; CINGULATE GYRUS; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEFT HEMISPHERE; MALE; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NEGATIVE FEEDBACK; PARIETAL LOBE; PARKINSON DISEASE; POSITIVE FEEDBACK; PREFRONTAL CORTEX; PREMOTOR CORTEX; PUTAMEN; RIGHT HEMISPHERE; STRIATE CORTEX; TASK PERFORMANCE; TEMPORAL CORTEX; WISCONSIN CARD SORTING TEST; CORPUS STRIATUM; DRUG EFFECT; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY;

AGED; COGNITION; CORPUS STRIATUM; FEMALE; HUMANS; LEVODOPA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PARKINSON DISEASE;

EID: 67650264886     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006154     Document Type: Article

References (30)

1. Emre M (2004) Dementia in Parkinson's disease: cause and treatment. Curr Opin Neurol. pp 399-404.
2. Taylor AE, Saint-Cyr JA, Lang AE (1986) Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow. Brain. pp 845-883.
3. Lees AJ, Smith E (1983) Cognitive deficits in the early stages of Parkinson's disease. Brain. pp 257-270.
4. Dagher A, Owen AM, Boecker H, Brooks DJ (2001) The role of the striatum and hippocampus in planning: a PET activation study in Parkinson's disease. Brain. pp 1020-1032.
5. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. pp 357-381.
6. Cools R, Stefanova E, Barker R, Robbins TW, Owen AM (2002) Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET. Brain. pp 584-594.
7. Mattay VS, Tessitore A, Callicott JH, Bertolino A, Goldberg TE, et al. (2002) Dopaminergic modulation of cortical function in patients with Parkinson's disease. Ann Neurol. pp 156-164.
8. Monchi O, Petrides M, Doyon J, Postuma RB, Worsley K, et al. (2004) Neural Bases of Set-Shifting Deficits in Parkinson's Disease. J Neurosci 24: 702-710.
9. Monchi O, Petrides M, Mejia-Constain B, Strafella AP (2007) Cortical activity in Parkinson's disease during executive processing depends on striatal involvement. Brain 130: 233-244.
10. Monchi O, Petrides M, Petre V, Worsley KJ, Dagher A (2001) Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J Neurosci 21: 7733-7741.
11. Nagano-Saito A, Leyton M, Monchi O, Goldberg YK, He Y, et al. (2008) Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task. J Neurosci 28: 3697-3706.
12. Lange KW, Robbins TW, Marsden CD, James M, Owen AM, et al. (1992) L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology (Berl). pp 394-404.
13. Gotham AM, Brown RG, Marsden CD (1988) 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain. pp 299-321.
14. Schubert T, Volkmann J, Müller U, Sturm V, Voges J, et al. (2002) Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's disease. Experimental brain research Experimentelle Hirnforschung Expérimentation cérébrale. pp 8-16.
15. Defer GL, Widner H, Marié RM, Rémy P, Levivier M (1999) Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD) Mov Disord. pp 572-584.
16. Langston JW, Widner H, Goetz CG, Brooks D, Fahn S, et al. (1992) Core assessment program for intracerebral transplantations (CAPIT). Mov Disord. pp 2-13.
17. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17: 427-442.
18. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, et al. (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society. pp 695-699.
19. Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, et al. (2002) A general statistical analysis for fMRI data. Neuroimage. pp 1-15.
20. Monchi O, Petrides M, Strafella AP, Worsley KJ, Doyon J (2006) Functional role of the basal ganglia in the planning and execution of actions. Ann Neurol 59: 257-264.
21. Huang C, Mattis P, Tang C, Perrine K, Carbon M, et al. (2007) Metabolic brain networks associated with cognitive function in Parkinson's disease. Neuroimage 34: 714-723.
22. Hirano S, Asanuma K, Ma Y, Tang C, Feigin A, et al. (2008) Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease. J Neurosci 28: 4201-4209.
23. Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, et al. (2008) Parkinson's disease and dopaminergic therapy-differential effects on movement, reward and cognition. Brain 131: 2094-2105.
24. Kish SJ, Shannak K, Hornykiewicz O (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med. pp 876-880.
25. Nandhagopal R, McKeown MJ, Stoessl AJ (2008) Functional imaging in Parkinson disease. Neurology 70(16): 1478-1488.
26. Cools R, Stefanova E, Barker RA, Robbins TW, Owen AM (2002) Dopaminergic modulation of high-level cognition in Parkinson's disease: The role of the prefrontal cortex revealed by PET. Brain 125: 584-594.
27. Mattay VS, Tessitore A, Callicott JH, Bertolino A, Goldberg TE, Chase TN, Hyde TM, Weinberger DR (2002) Dopaminergic modulation of cortical function in patients with Parkinson's disease. Ann Neurol 51: 156-164.
28. Gotham AM, Brown RG, Marsden CD (1988) 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain 111(2): 299-321.
29. Cools R (2006) Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev 30(1): 1-23.
30. Lange KW, Paul GM, Naumann M, Gsell W (1995) Dopaminergic effects on cognitive performance in patients with Parkinson's disease. J Neural Transm Suppl 46: 423-32.